| UniProt ID | ITPR_DROME | |
|---|---|---|
| UniProt AC | P29993 | |
| Protein Name | Inositol 1,4,5-trisphosphate receptor | |
| Gene Name | Itp-r83A | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 2838 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein. |
|
| Protein Description | Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. May be involved in visual and olfactory transduction, and myoblast proliferation.. | |
| Protein Sequence | MGDNIIGSASFLHLGDIVSLYAEGSVCGFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIKICPMNRYSAQKQFWKAAKQSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQYGRAVVQLLHLKSNKYLTVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYVVVVGDKVILSPVNADQQNLHVAANYELPDNPGCKEVNVLNSSTSWKISLFMEHKENQEHILKGGDVVRLFHAEQEKFLTMDEYKKQYHVFLRTTGRTSATAATSSKALWEIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAEIDVSAGAMSATSASGHDLHLGDCSKDSGLSCSTMNSTINDKPKGKQYRLVSVPYSADIASVFVLDATTMARPDSLVPQSSYVRLQHICSNTWVHATSIPIDADDDKPVMSMVCCSPIKEDKEAFALIPVSPVEVRDLDFANDACKVLATVTSKLDNGSISINERRALISLLQDIVYFIAGMENEQNKTKALEFTIKNPIRDRQKLLREQYILKQLFKILQGPFQEHTAGDGPFLRLDELSDPKNSPYKNIFRLCYRILRLSQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLLEKHITAAEIETFVGLVRKNMHNWDSRFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKDILIETQVKALRTGSGPVRCYKGNSEDVCLATLAEDPGDDEDRSDVQSTSTTTTWDSASLNEDDGTPSTGDKYEIHLKWTGQPTSRSMADLASCDGGELEAAILNYYRHQLNLFSNMCLNRQYLALNELSPRLDIDLILKCMSDETMPYELRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEIPSKMSIQDYDGKNQQPDQNKQACRAKFNTTIAFVENYLCNVATKVWLFTDQEQNKLTFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCVSDTSSGEFASTDIDSVEEETNAEAEGGVLRSIGDINTVMTSLALGSVGQAIAAPTISLQQRKSVSQLMKEYPLVMDTKLKIIEILQFILDVRLDYRISCLLSIFKREFDESEVAASAASNEASQQQSQQQEPQTPGSSNETDPLDSAESVAAGAAAAAATTARQKNIDLESIGVQAEGIFDCERSDAANLDLDGQGGRTFLRVLLHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVESYKQIKSDLDILRQSVEKSELWVYKAKATDELGATDAGGDAVSLEYNAALSQEQRNEYRKVKEILIRMNKFCVTASGPGSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELMCLAHEFLQNFCLGNQQNQVLLHNHLDLFLNPGILEAKTVCAIFKDNLALCNEVTDKVVQHFVHCIEIHGRHVAYLQFLQTVVAAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQMLGMEKLSDDSPLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEVKEAYVDFLNHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQLITNPAAASNKTLQAYVLNGVTNLLGSFFASPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLGDRFNVENCIRTLTESAKMRSIALPPELEQQVATMSSKTAMLTRQTTKWLLASKQPKYEAQQAASLMRWDRSIIEGLQDIVSLLEDQLKPVVEAELSLLVDILYRSELLFPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLREMMAIDVNYGEKGDALRQTLLLRYFQTKSTPRLPEDEVPLLAAPLMDPAKQNHLVTHGPGAKYLQRAGKTLHEMQNHLDREGASDLVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGMFQKFLSDDLNQAFFKVFFEKMKDAQQEIKSTVTVNTTDIAAKAHEHKQDTNLELDKIARKHGLKSNGVVITEELKRELHNAGLATARAYGNARNIHSGEESSAISVNSPLEDILAEKLEKHKDSRDQRNQLSNKVLVMQPILRFLQLLCENHNPDMQNLLRNQNNKTNNNLVSETLMFLDCICGSTTGGLGLLGLYINEHNLALINQTLEALTEYCQGPCHENQNCIATHESNGLDIITALILNNINPLGENRMDLVLELKNNASKLLLAIMESRGDSENAERILYNMNPKQLVEVACKAYHQEELIDEQDDGDEPDAGSDDDDATVSPREVGHNIYILCHQLAQHNKELAGLLKASEDPQSASFDAKTSQALMYYATHTAQIEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQGSKLADFFDKAEEMFNEMKWQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPFDNTVPELSSHISLLFWIITIFSLVIVLALPRESGIRTFIGSVILRFIFLLGPESTLCLLGVVTVTLKSVHIVSIMGNKGTLEKQLIKIITDFQLLYHCIYIAFCFCGLIFHPFFYSLLLFDVVYREETLVNVIRSVTRNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSVDFEEQDNAPPPSVPLTLSVPVSGDSCSAPDDLGNCQAAKEVAPPSAGGGEVKERSCDSLVMCIVTTLNQGLRNGGGIGDILRAPSSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQQKEAILKTTCFICSLNRSAFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEFTGPESYVYAMVKAGILEWFPRLRAMSLAAVDADGEQIELRSMQAQLLDTQLLIKNLSTQLHELKDHMTEQRKQKQRLGLLNTTANSLLPFQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1022 | Phosphorylation | AIAAPTISLQQRKSV HHHCCCCCHHHHHCH | 23.70 | 22668510 | |
| 1030 | Phosphorylation | LQQRKSVSQLMKEYP HHHHHCHHHHHHHCC | 25.37 | 27794539 | |
| 1651 | Phosphorylation | TESAKMRSIALPPEL HHHHHHHHCCCCHHH | 14.55 | 28490779 | |
| 1673 | Phosphorylation | SSKTAMLTRQTTKWL CHHHHHHHHHHHHHH | 13.98 | 28490779 | |
| 1812 | Phosphorylation | LRYFQTKSTPRLPED HHHHCCCCCCCCCCC | 47.21 | 27794539 | |
| 1813 | Phosphorylation | RYFQTKSTPRLPEDE HHHCCCCCCCCCCCC | 17.62 | 27794539 | |
| 2226 | Phosphorylation | GDEPDAGSDDDDATV CCCCCCCCCCCCCCC | 39.32 | 19429919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ITPR_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ITPR_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ITPR_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CYA1_DROME | rut | genetic | 11333238 | |
| STIM_DROME | Stim | genetic | 20107057 | |
| GNAQ_DROME | Galphaq | genetic | 16899722 | |
| TY3H_DROME | ple | genetic | 26446229 | |
| INSL2_DROME | Ilp2 | genetic | 23471909 | |
| PSN_DROME | Psn | genetic | 20631179 | |
| RAS1_DROME | Ras85D | genetic | 26544939 | |
| JNK_DROME | bsk | genetic | 23471909 | |
| ATC1_DROME | Ca-P60A | genetic | 16899722 | |
| VDAC_DROME | porin | physical | 27093086 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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