GRM_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRM_DROME
• UniProt AC: P91685
• Protein Name: Metabotropic glutamate receptor
• Gene Name: mGluR
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 976
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors..
• Protein Sequence: MKQKNNNGTILVVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKGEGAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNGLQLNSETVVWNKETEQPTSACSLPCEVGMIKKQQGDTCCWICDSCESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDRREVILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGAPTSSGYSRTHAPGTSALTGGAVGTNASSSTLPTQNSPHLDEASAQTNVAHKTNGEFLPEVGERVEPICHIVNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
112	N-linked_Glycosylation	SRDTYALNQSLQFVR CCHHHHHHHHHHHHH	22.63	17893096
143	N-linked_Glycosylation	SSPQLRKNASSGPVF CCHHHHHHCCCCCEE	38.32	-
216	N-linked_Glycosylation	VDILKNFNWSYVSTI HHHHHHCCCEEEEEE	35.86	-
299	N-linked_Glycosylation	LQAAKRANLSQPFHW HHHHHHCCCCCCCEE	44.23	-
386	N-linked_Glycosylation	PDTSNSANSTDNKIG CCCCCCCCCCCCCCC	45.31	-
456	Phosphorylation	ETRKHLQSESVWYRK HHHHHHHHHCEEEEE	37.89	22817900
461	Phosphorylation	LQSESVWYRKISTDT HHHHCEEEEECCCCC	10.40	22817900
491	N-linked_Glycosylation	FYNNYLLNVSFIDLA HHHHEEEEEEEEECC	25.45	-
524	N-linked_Glycosylation	LNYQRQENSSGYQYK EEEECCCCCCCCEEE	32.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRM_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRM_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRM_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FMR1_DROME	Fmr1	genetic	19036865
FMR1_DROME	Fmr1	genetic	18280750
KCC2A_DROME	CaMKII	genetic	21515581

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Identification of N-glycosylated proteins from the central nervoussystem of Drosophila melanogaster.";
Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L.,Panin V.;
Glycobiology 17:1388-1403(2007).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-112, AND MASSSPECTROMETRY.
PubMed: 17893096