MIC60_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIC60_DROME
• UniProt AC: P91928
• Protein Name: MICOS complex subunit Mic60
• Gene Name: Mitofilin {ECO:0000312|FlyBase:FBgn0019960}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 739
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein .
• Protein Description: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (By similarity)..
• Protein Sequence: MYRLAVRDQCKCALQRTLQQTTANNRQFGGSSSGSGGREQGRRQQEEQGQQGDQGYQGYQSLPPHMREAGFGKVVLFVSPLAAVGGVITYAKYDDDFRKLVEKNVPGAGSVIKVALQEEPPFKGITKNVNDQIDKVKSGIETVTSTVDSVTSKVTGLFGGGSGDDKSKKSKVEPVKATPAEEKRPSKPSEVSKTEAKPVSKPAAAAAPAPAAKPKDNPLPRDVVELEKAIELSAQLAVKEYNVAIGVLKGFNDDVRKVVDKAVENGENSLWTTLKNRASARDTAVATAERAAREAQEKIVACEIALSAAATAQNAKKVEAVRDKIKKLVDHIGNVKDELYRHKDTASVSDKYWRNVEKARNYFIDEIESIFPGLSLADKKLNLSKEDLDLFILHAYTHVLAYQKELQRLQTDGELRLKRAIDSVRGDNDSEALRAQLEYHLEAERRKLAVENQKKIFHIHAESDKLLRLQLKKQAEAHADHIKDIVAQRETDLTRSFKRELEDKLATEKANYKLQLAGMLGKLRGMDAALAERADAERTANQAQALWAACQALWASVRAATPGVHYKDRLRPLKNEINAIAKVAKGDDLVAAVLESVPKEAQERGVYPEDALRERFLNVERVARRLALVPEEGAGLPIYFLSYLQSLFILRPDNPISKDELENKPFDYSKLDTYDILNRARYHVDRSDFLQALKYMNLLQGASRKIAGEWMKEARLMLETQQAANTLMAHAAASGLLYL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
162	Phosphorylation	TGLFGGGSGDDKSKK CCCCCCCCCCCCCCC		27794539
327	Acetylation	AVRDKIKKLVDHIGN HHHHHHHHHHHHHHC		21791702
351	Acetylation	DTASVSDKYWRNVEK CCCCCCHHHHHHHHH		21791702
455	Acetylation	LAVENQKKIFHIHAE HHHHCHHHEEEEEEC		21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MIC60_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIC60_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIC60_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAP47_DROME	Sap47	physical	14605208
SAM50_DROME	CG7639	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.