RS2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RS2_DROME
• UniProt AC: P31009
• Protein Name: 40S ribosomal protein S2
• Gene Name: RpS2
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 267
• Protein Description: Has a specific developmental role during oogenesis and a general role in protein synthesis as a component of the small ribosomal subunit..
• Protein Sequence: MADEAPARSGFRGGFGSRGGRGGRGRGRGRWARGRGKEDSKEWVPVTKLGRLVREGKIKSLEEIYLYSLPIKEFEIIDFFLGSSLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDNNGHIGLGVKCSKEVATAIRGAIILAKLSVVPVRRGYWGNKIGKPHTVPCKVTGKCGSVSVRLIPAPRGTGIVSAPVPKKLLTMAGIEDCYTSARGSTGTLGNFAKATYAAIAKTYAYLTPDLWKEMPLGSTPYQAYSDFLSKPTPRLHADA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Phosphorylation	VREGKIKSLEEIYLY HHCCCCCCHHEEEEE	44.48	19429919
65	Phosphorylation	IKSLEEIYLYSLPIK CCCHHEEEEEECCCC	11.67	22817900
97	Acetylation	LKIMPVQKQTRAGQR HHHCCCCCCCCCCCC	54.60	21791702
249	Phosphorylation	MPLGSTPYQAYSDFL CCCCCCCCHHHHHHH	13.08	18281928
252	Phosphorylation	GSTPYQAYSDFLSKP CCCCCHHHHHHHCCC	8.01	21082442
253	Phosphorylation	STPYQAYSDFLSKPT CCCCHHHHHHHCCCC	25.54	21082442
257	Phosphorylation	QAYSDFLSKPTPRLH HHHHHHHCCCCCCCC	36.26	21082442
260	Phosphorylation	SDFLSKPTPRLHADA HHHHCCCCCCCCCCC	25.44	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RS2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RS2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RS2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FL2D_DROME	fl(2)d	physical	14605208
DORS_DROME	dl	physical	14605208
DYM_DROME	CG8230	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, AND MASSSPECTROMETRY.
PubMed: 18327897