dbPTM

DYM_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DYM_DROME
UniProt AC	Q7KNA0
Protein Name	Dymeclin
Gene Name	CG8230
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	699
Subcellular Localization
Protein Description
Protein Sequence	MGINVSRTADLGSNQWLQRFVGRQHIAHDDEAFWNGLLNYNIVLPENSQDQLNLDSRLEALCQSFIGNNLKTGNFGSLVTVFLEKTSELLSLSDQESNMHVWQTFNALFIIRSLVKYINETGSEFQLLQHFEAMPNAELLQAALEQQQQTPAESATIAMEATEQSAAAAVPVIVDGSKFETFIDALVNLIVVIPVKEFTYHLHLEAVNMLITLLSVHLFAQQPTDKSIVFRTVFKCQHANVLMSALLHFVARIVEVPHTMFGSSSAGSFVFGIAESLLSIFTFRKQPDILKAGQAAGGGELSQRFRTHYPLANQSLLLILILTNHCTAQDNAYRTSLFSCADSKDSPKQGAVSFQIDFSAVYETLCTIVTIDQATLLLYLLLHRNERFYRFVMQQQDLEQLVIPILQTLYNAPDSNSHHIYMSLIVLLILSEDEGFNKNVHTIMLKNITWYTERTISEISLGGILILIVIRTIQYNMLKMRDKYLHTNCLAALANMSGHFRALHPYVAQRLVSLFETLARKHTRLDAQLKEPADSAVFVNVSTTPEDMLQDLSVLEEVLRMVLEILNSCLTNQLVYCPNLVYTLLYKRSVFEGFRSHHAFQDVIQNIDMVVGFFSSRLQRVQEQRGELGVNEVLEVISKGASQWSSDRLRKFPDLKFKYVEEDAPEEFFIPYVWTLVCKYGCVHFSSESIKSVTTDIAC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGINVSRTA ------CCCCCCCCC	21.85	-
77	Phosphorylation	LKTGNFGSLVTVFLE CCCCCCCHHHHHHHH	18.61	21082442
343	Phosphorylation	SLFSCADSKDSPKQG HHHECCCCCCCCCCC	21.60	22817900
346	Phosphorylation	SCADSKDSPKQGAVS ECCCCCCCCCCCCEE	37.42	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DYM_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DYM_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DYM_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DYM_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-346, AND MASSSPECTROMETRY.	18327897 [Abstract]
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells."; Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.; Mol. Biosyst. 3:275-286(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-346, AND MASSSPECTROMETRY.	17372656 [Abstract]