PCX_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCX_DROME
• UniProt AC: P18490
• Protein Name: Protein pecanex
• Gene Name: pcx
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 3413
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Involved in neurogenesis..
• Protein Sequence: MGSQTLEILRQGVWASLTGGYFYDPHQGVFCNVVHLYLWLYLLCSPFVAYLYFPSTWLTWCLYCVITSLTILMVKLANLALHRLYDRAQTMSEGNLKGQFVKVTKETEPRHDDEGGIEMKVIRPGGSRISGEQAINEASEENSIMSIDNVNSIIDLKVDVHRKNSSESIELMFYAPSMLSGGSQQDQQSLAGSASVSKSIRSTGPGGNSSTSAAAQADMFNKYLTVYPEVVEAAGSSAGSADGGSSGGDSRSGAAVSTLGHTGAGTAPAQHVRTGHLSRKCSEVFSRRHRRRLERQSSLDTAAAAANSNAENKLMRNQSDTIATAAPSFLHSQPTNKARGQTNPRQHFITSAPSTGIGGGDAPTSSTAVVVIAPASNSLVNPGRSSRLQRHRSSETHDERLKHQSRGGLFQPILQLPHHSAASSIGALAVLGGGGNVAANDVEDMELGLVRNAGSGGVADACSRALQSWILDPFPDGYLEDDSYTKSDLGIEQPHQPTFRTQHRHHHHHHHLHHHLGGAIIRKDPTSTMSALQLAAVTQPGTGGSVTGGGGAAGGGGSAAGMKRRRHSNATSYKHGSSQSNKSSLVGGGGSRGPSGEAGTSGGAGGTGGVRRIKSAALEVLCPQPSVSNLSPHPNSVEAISGQQQMRNPLPPPSKSLVRNQHLNLYPTQGYGDGTPSAGGGGPGNSSTCSSLFFGSSSACGSTTALIEPPVYPIVEHSDEKTAHEEHGDDCLGIGQGNADDDDEVDDVPIRRRTRALGCSQTHYSVESDVGGFLADEVGADEDVFKDFDDNLEHILSELQQTHNQLDDVLKTHDLHHHSHLHHHKAASVEGAGPSGGSVAVGVSAGNDDEDEETEDNNTGSRSPLLNDRNRQPATLREIQADKQLRQELSHQSGAVIPAPNPPVPIRSEADSGCPSSDCEQVSASSKDQLLSGIELELQQYQILQRCQLDEEQPCTSKMAAKSLGAIPKVVKYREVDELRRRRRGGSPADAAEAGNEFALVKQTKQASRNSSSSNSTHSISLTDSLTADIHKMLWLMHGGAVDDRGRPITGTSADGTPIPASSSLVPPNMSNAHFQFYQDAIQALQGTHPTSGSSVEHMTNIELARDKLRLDAKLMCEQLVAAAEANSGVRGNTLATQQMTQQQVGMLMRGGSSSRHPSSAPFSVQGLINVIRSERPAARSQLDALQQLSDAAAALAANASEAASVSASGAGGGASSGGGGVLSALGLANHPSNQISQISQLSQMSQPMLNVDGHFAPYCDYWRPACLLSATEKPAAPKSFYKYRFKWCGQEHEFKIAMDRLELLALFDRDLHWMHVLLASLLCTLVACLGAAILQHDHYKDLCALLFCAVIAGAQYSLVKSVQPDAASPVHGFNKTVAYSRAIYFCLAGGMLLLLKRLDTDYGERTPDPVVFFGMRYSPADVVALLLQALYILLLCFPIIFSVGLCPQINTFLMYLLEQIDMHVFGGNAASSLLGSFLCVVRSVLAVMLLYGPLYGALDEQRGTQYILFSIFCAMLVPLGYHLSRCASDFSHLWRLIKTCIVSTYRDDEDEDLSQMQHIATGTVTGSGTANSTALQLTTSTPKQHRQTDVKTEHEQIELSSLEKLTVNEEHHEKDHGADDQLETDQDLPLQQKHSKSKTSSLGSSQQTLGKTISSSKRAITASSSCTSIGTGEPAVEAGALTEEAVEGEEQRRNTLAGEVGSKHELAENYDQAAKIDECEDKISSSSATNPGDMSTLTAGAGTATTDATPACLEADPDAEAEAPADEKQHQGILGTGTGTGTGTTEASENGSGGGANGNTNSNGTGNDLPDPLPRKLQATVTTRLKNDLVVMTLLAVSVLGLHCSTVFTALQPDLNVVLYSFIGVLGLLLHYIVPQMRKHMPWLCFSRPLLRQREFGQFEVLNAPKIMWFEKLYIYLSVLERNVLFPLLAISSLTADSQLIVAKFGLPWGTLIVAICALKFVRNAYSDPTNQYLIIIFTVLLFRIDFAMATETFIIDYFFVSLAFRKCCDFLLKLQFIVTYIAPWQITWGSAFHAFAQPFSVPHSAMLFLQAAISAVLSTPLNPFLGSAIFLTSYVRPIKFWERDYNTRRIDHSNTRLSSQLERDLGADDNNLNSIFYEHLTRSLQHSLCGDLLMGRWGNVNQGDCFVLASDDLNCLVHIIELGNGLCTFQMRGLEFRGTYCQQREVEAITEDVEDNDGCCCCDPGHLPQLLSANAMFSTRWLAWQVVAAQYVIEGYSISDNLASATLQVFEYRKVLITYYIKSIIYYVVKNPKLEQWLASGPIQDALQHTLSRQFVDLDPIFNFNLDEDFDFRAVGITRSSFCYVYLKWINYCVDMRRDANSMGGAPPAQAPAAAGGASSAPATAGVAPPAPVTPAHNDSKSTPNLSAHGGQAGPSSGQSKSQSQQQLRRPQKSVAQETSVGGGGVVVGGTTVPGTGGVTGGGGDPQLSSSHSFANISRQTSESAPGLGGYVAYMDQNVFVKLAKSSTTTGAGAGAPTSRKESQEKPALRLKLASVGKDAPLVSLCLALGLLARRSLATASHSALTGVEFFLHGLHALFKGDFRITSPRDEWVFADMELLHSVVAPAVKMALKLQQDHITNPDEFLDPHALYDAIDNCSNELVISHEADPVWRSAVLRGAPNLLALRHVMEDGSDEYRIIRLTKRCLSFRVIKLNRECVRGLWAGQQQELIYLRNRNPERGSIQNAKQALRNIINSSCDQPIGYPIYVSPLTTSYADTNAQLCEVIGGAITLDTIRHTVLGWWHRIRERCRQGCSSGSALEPHPGSGPVQLGACNFGSGGSVVGAASTATGVGASTGSGLGVAAPGTAGSTGGESGDLAPVFISAPLYNTLTVNSYYSVRPGNVPGGPIPGNLGGNYVSDSLAVVRGGLAVMPVKPTSTTLIAGLLNRERDETSGSGIMGAGASGPTRATSSGGVRSRRPEVGSSRGRDHERRATLPIASGGAGGEPGKDLTAPQTQVEHEPSPRSTKLSSSSGSLGLGMGVGLGNIITTPGDYPRKTKGPICLTAVDTGTSSSAAEGKPAGSGTVAGTGVGGVIRKPRIEIFKKVIIVDDTGIYDCLDIIDAVVWPTERMRNNGGRLSWKDWEPSAGMVGHVVHCWTPNHKDIRFRSHVNRYVYLVEIGDHYVPVEELGLREYNQIMGSTEEMANSRRSSIQRDFHEYNIQLKLAGLAPIIGGGESSTATTSDASKSHKAKIRAVSSSSSEDEDTSSTRSIPLPQGDDGDLTNFTRLVSMWKEIILDNNKRRLYDMGELSPELLQKLDDAVQQQQQLEDALAEESKEKGTATVTANEGEEGVGEMEIEPEQEQKEVVYLEEQSPLEEVTVSKPDEQPAQPTIPASPVPAETSSTSSAKSTSSPSLCQEEEDAVDPEETPELASEESPSDENGESEAGTTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
164	N-linked_Glycosylation	KVDVHRKNSSESIEL EEEEECCCCCCCEEE	51.21	-
208	N-linked_Glycosylation	RSTGPGGNSSTSAAA HCCCCCCCCHHHHHH	38.41	-
298	Phosphorylation	RRLERQSSLDTAAAA HHHHHHHCHHHHHHH	23.17	22668510
317	N-linked_Glycosylation	AENKLMRNQSDTIAT HHHHHHHCCHHHHHH	31.57	-
455	Phosphorylation	GLVRNAGSGGVADAC CCEECCCCCCHHHHH	29.93	22817900
463	Phosphorylation	GGVADACSRALQSWI CCHHHHHHHHHHHHH	23.47	22817900
569	N-linked_Glycosylation	MKRRRHSNATSYKHG CCCCCCCCCCCCCCC	40.90	-
581	N-linked_Glycosylation	KHGSSQSNKSSLVGG CCCCCCCCCCCCCCC	40.36	-
685	N-linked_Glycosylation	AGGGGPGNSSTCSSL CCCCCCCCCCCCCHH	35.60	-
857	N-linked_Glycosylation	EDEETEDNNTGSRSP CCCCCCCCCCCCCCC	41.55	-
987	Phosphorylation	RRRRRGGSPADAAEA HHHHCCCCHHHHHHH	21.53	19429919
1010	N-linked_Glycosylation	QTKQASRNSSSSNST HHHCHHCCCCCCCCC	43.69	-
1015	N-linked_Glycosylation	SRNSSSSNSTHSISL HCCCCCCCCCCCEEC	53.53	-
1069	N-linked_Glycosylation	SSSLVPPNMSNAHFQ CCCCCCCCCCCHHHH	40.21	-
1199	N-linked_Glycosylation	AAAALAANASEAASV HHHHHHHCHHHHHCC	38.09	-
1375	N-linked_Glycosylation	ASPVHGFNKTVAYSR CCCCCCCCHHHHHHH	43.62	-
1572	N-linked_Glycosylation	VTGSGTANSTALQLT CCCCCCCCCEEEEEE	39.47	-
1601	Phosphorylation	EHEQIELSSLEKLTV HHHHHHHHHHEECCC	21.78	19429919
1602	Phosphorylation	HEQIELSSLEKLTVN HHHHHHHHHEECCCC	53.85	19429919
1791	N-linked_Glycosylation	GTTEASENGSGGGAN CCCCCCCCCCCCCCC	47.65	-
1804	N-linked_Glycosylation	ANGNTNSNGTGNDLP CCCCCCCCCCCCCCC	54.86	-
2380	N-linked_Glycosylation	APVTPAHNDSKSTPN CCCCCCCCCCCCCCC	10.21	-
2387	N-linked_Glycosylation	NDSKSTPNLSAHGGQ CCCCCCCCCCCCCCC	16.75	-
2458	N-linked_Glycosylation	SSSHSFANISRQTSE CCCCCCCCCCCCCCC	25.37	-
2619	N-linked_Glycosylation	ALYDAIDNCSNELVI HHHHHHHCCCCCEEE	23.38	-
2717	N-linked_Glycosylation	QALRNIINSSCDQPI HHHHHHHHHCCCCCC	45.55	-
2777	Phosphorylation	ERCRQGCSSGSALEP HHHHCCCCCCCCCCC	2.79	22817900
2778	Phosphorylation	RCRQGCSSGSALEPH HHHCCCCCCCCCCCC	22.86	22817900
2780	Phosphorylation	RQGCSSGSALEPHPG HCCCCCCCCCCCCCC	13.94	22817900
2797	Phosphorylation	PVQLGACNFGSGGSV CEEECEEECCCCCCC	44.55	22817900
2798	Phosphorylation	VQLGACNFGSGGSVV EEECEEECCCCCCCC	40.62	22817900
2800	Phosphorylation	LGACNFGSGGSVVGA ECEEECCCCCCCCCC	31.46	22817900
3246	N-linked_Glycosylation	GDDGDLTNFTRLVSM CCCCCCCHHHHHHHH	60.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCX_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCX_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCX_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOTCH_DROME	N	genetic	22190636
HSP7C_DROME	Hsc70-3	genetic	22190636
OFUT1_DROME	O-fut1	genetic	22190636

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.