PRS8_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRS8_DROME
• UniProt AC: O18413
• Protein Name: 26S proteasome regulatory subunit 8
• Gene Name: Rpt6
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 405
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity)..
• Protein Sequence: MTVTNRMEIESAYHKGEGFRSYYIQKIEELQLVVAEKHQNLRRLQAQRNELNAKVRMLREELQLLQEQGSYVGEVVKPMDKKKVLVKVHPEGKFVVDLDKNIDINDVTPNCRVALRNESYTLHKILPNKVDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFDALGIAQPKGVLLYGPPGTGKTLLARAVAHHTECTFIRVSGSELVQKFIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRIESGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDPALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	Acetylation	DKKKVLVKVHPEGKF CCCEEEEEEECCCCE	30.57	21791702
119	Phosphorylation	RVALRNESYTLHKIL EEEECCCCEEHHHHC	27.28	22668510
120	Phosphorylation	VALRNESYTLHKILP EEECCCCEEHHHHCC	13.72	22668510
121	Phosphorylation	ALRNESYTLHKILPN EECCCCEEHHHHCCC	31.50	22668510
195	Ubiquitination	YGPPGTGKTLLARAV ECCCCCCHHHHHHHH	35.52	31113955
329	Acetylation	EARLDILKIHSRKMN HHHHHHHHHHHHCCC	38.41	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRS8_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRS8_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRS8_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BECN1_DROME	Atg6	physical	14605208
CPSF3_DROME	Cpsf73	physical	14605208
ODD_DROME	odd	physical	14605208
CNN_DROME	cnn	physical	14605208
TFP11_DROME	sip1	physical	14605208
PSB3_DROME	Prosbeta3	physical	22036573
PSA1_DROME	Prosalpha6	physical	22036573
PSA4_DROME	Prosalpha3	physical	22036573
PSB4_DROME	Prosbeta7	physical	22036573
PSA2_DROME	Prosalpha2	physical	22036573
PSA3_DROME	Prosalpha7	physical	22036573
ADRM1_DROME	Rpn13	physical	22036573
PSMD1_DROME	Rpn2	physical	22036573
PSD11_DROME	Rpn6	physical	22036573
PSDE_DROME	Rpn11	physical	22036573
PSA6_DROME	Prosalpha1	physical	22036573
NFS1_DROME	CG12264	physical	22036573
PSMD3_DROME	Rpn3	physical	22036573
IDH3A_DROME	l(1)G0156	physical	22036573
PSMD6_DROME	Rpn7	physical	22036573
PRS8_DROME	Rpt6	genetic	9469929

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.