| UniProt ID | ADRM1_DROME | |
|---|---|---|
| UniProt AC | Q7K2G1 | |
| Protein Name | Proteasomal ubiquitin receptor ADRM1 homolog | |
| Gene Name | Rpn13 | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 389 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | May function as a proteasomal ubiquitin receptor. May promote the deubiquitinating activity associated with the 26S proteasome (By similarity).. | |
| Protein Sequence | MFGRQSGLGSSSNSSNLVEFRAGRMNMVGKMVHPDPRKGLVYMTQSDDGLMHFCWKDRTSGKVEDDLIVFPDDFEYKRVDQCKTGRVYVLKFKSSTRRMFFWMQEPKTDKDDEQCRRINELLNNPPSAHQRGGGGSNDGDLQYMLNNMSQQQLMQLFGGVGQMGGLSSLLGQMNSRTPSSRNTSSSGGGGASALQTPENVSVPRTPSAPSKSGSSRSSSNVNSQVGEGAGSSVDADAPGRSLNIDLSTALPGADAINQIIADPEHVKTLIVHLPESEDVDDDRKQQIKDNITSPQFQQALAQFSSALQSAQLGPVIKQFELSNEAVAAAFSGNLEDFVRALEKSLPPGATMGGKPSASEKKASDPETPTSVARDENTDPATEKQEEKQK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MFGRQSGLGSSSN --CCCCCCCCCCCCC | 34.33 | 19429919 | |
| 183 | Phosphorylation | RTPSSRNTSSSGGGG CCCCCCCCCCCCCCC | 28.95 | 19429919 | |
| 184 | Phosphorylation | TPSSRNTSSSGGGGA CCCCCCCCCCCCCCC | 26.51 | 19429919 | |
| 185 | Phosphorylation | PSSRNTSSSGGGGAS CCCCCCCCCCCCCCC | 30.85 | 19429919 | |
| 186 | Phosphorylation | SSRNTSSSGGGGASA CCCCCCCCCCCCCCC | 41.02 | 19429919 | |
| 192 | Phosphorylation | SSGGGGASALQTPEN CCCCCCCCCCCCCCC | 32.55 | 19429919 | |
| 196 | Phosphorylation | GGASALQTPENVSVP CCCCCCCCCCCCCCC | 33.16 | 19429919 | |
| 201 | Phosphorylation | LQTPENVSVPRTPSA CCCCCCCCCCCCCCC | 37.68 | 28490779 | |
| 205 | Phosphorylation | ENVSVPRTPSAPSKS CCCCCCCCCCCCCCC | 18.61 | 28490779 | |
| 207 | Phosphorylation | VSVPRTPSAPSKSGS CCCCCCCCCCCCCCC | 52.80 | 28490779 | |
| 211 | Acetylation | RTPSAPSKSGSSRSS CCCCCCCCCCCCCCC | 58.75 | - | |
| 211 | Acetylation | RTPSAPSKSGSSRSS CCCCCCCCCCCCCCC | 58.75 | 21791702 | |
| 217 | Phosphorylation | SKSGSSRSSSNVNSQ CCCCCCCCCCCCCCC | 39.81 | 19060867 | |
| 218 | Phosphorylation | KSGSSRSSSNVNSQV CCCCCCCCCCCCCCC | 25.48 | 19060867 | |
| 219 | Phosphorylation | SGSSRSSSNVNSQVG CCCCCCCCCCCCCCC | 46.15 | 17372656 | |
| 223 | Phosphorylation | RSSSNVNSQVGEGAG CCCCCCCCCCCCCCC | 23.20 | 29892262 | |
| 252 (in isoform 2) | Phosphorylation | - | 36.62 | 21082442 | |
| 263 (in isoform 2) | Phosphorylation | - | 25.27 | 23607784 | |
| 265 (in isoform 2) | Phosphorylation | - | 31.59 | 19429919 | |
| 268 (in isoform 2) | Phosphorylation | - | 22.19 | 19429919 | |
| 363 | Phosphorylation | SASEKKASDPETPTS CHHHCCCCCCCCCCC | 63.68 | 22817900 | |
| 367 | Phosphorylation | KKASDPETPTSVARD CCCCCCCCCCCHHCC | 36.94 | 19429919 | |
| 369 | Phosphorylation | ASDPETPTSVARDEN CCCCCCCCCHHCCCC | 43.16 | 19429919 | |
| 370 | Phosphorylation | SDPETPTSVARDENT CCCCCCCCHHCCCCC | 18.25 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ADRM1_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ADRM1_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ADRM1_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ACT1_DROME | Act5C | physical | 14605208 | |
| BNB_DROME | bnb | physical | 14605208 | |
| PSA1_DROME | Prosalpha6 | physical | 22036573 | |
| PSA4_DROME | Prosalpha3 | physical | 22036573 | |
| PSB4_DROME | Prosbeta7 | physical | 22036573 | |
| PSA2_DROME | Prosalpha2 | physical | 22036573 | |
| PSMD3_DROME | Rpn3 | physical | 22036573 | |
| RS27A_DROME | RpS27A | physical | 24292889 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6; THR-196; THR-205;SER-207; SER-217; SER-219 AND THR-367, AND MASS SPECTROMETRY. | |
| "An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells."; Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.; Mol. Biosyst. 3:275-286(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6; SER-185; SER-217;SER-218 AND SER-219, AND MASS SPECTROMETRY. | |
