PSDE_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSDE_DROME
• UniProt AC: Q9V3H2
• Protein Name: 26S proteasome non-ATPase regulatory subunit 14
• Gene Name: Rpn11
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 308
• Protein Description: Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity)..
• Protein Sequence: MDRLLRLGGAMPQAAPPTDAPVVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVQVIDVFAMPQTGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINPNMLVLGQEPRQTTSNLGHLQKPSVQALIHGLNRHYYSISINYRKNELEQKMLLNLHKKSWKDGLTLSDYNEHCSINEDTVAEMLDLAKNYNKSLEDEEKMTPEQLAIKNVGKQDPKRHLEEKVDKVMQNNIVQCLGAMLDTIVFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
175	Phosphorylation	LGQEPRQTTSNLGHL CCCCCCCCCCCCCCC	33.21	21082442
176	Phosphorylation	GQEPRQTTSNLGHLQ CCCCCCCCCCCCCCC	13.79	21082442
255	Ubiquitination	DLAKNYNKSLEDEEK HHHHHHCCCCHHHHC	46.16	31113955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSDE_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSDE_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSDE_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSMD7_DROME	Rpn8	physical	14605208
ADRM1_DROME	Rpn13	physical	22036573
PSA1_DROME	Prosalpha6	physical	22036573
PSA4_DROME	Prosalpha3	physical	22036573
PSB4_DROME	Prosbeta7	physical	22036573
PSMD3_DROME	Rpn3	physical	22036573
PSA2_DROME	Prosalpha2	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.