| UniProt ID | PSD11_DROME | |
|---|---|---|
| UniProt AC | Q7KLV9 | |
| Protein Name | 26S proteasome non-ATPase regulatory subunit 11 | |
| Gene Name | Rpn6 | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 422 | |
| Subcellular Localization | ||
| Protein Description | Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, RPN6 is required for proteasome assembly (By similarity). May act as linker between 19S regulatory subunit and the 20S proteasome core.. | |
| Protein Sequence | MAGATLFERAQALSSVNREEQDSSLLNKLVRDQEGAENDEERIRIKEQGILQQGELYKQEGKAKELADLIKVTRPFLSSISKAKAAKLVRSLVDMFLDMDAGTGIEVQLCKDCIEWAKQEKRTFLRQSLEARLIALYFDTALYTEALALGAQLLRELKKLDDKNLLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCPPKVQGALDLQSGILHAADERDFKTAFSYFYEAFEGFDSVDSVKALTSLKYMLLCKIMLGQSDDVNQLVSGKLAITYSGRDIDAMKSVAEASHKRSLADFQAALKEYKKELAEDVIVQAHLGTLYDTMLEQNLCRIIEPYSRVQVAHVAESIQLPMPQVEKKLSQMILDKKFSGILDQGEGVLIVFEETPVDKTYERVLETIQSMGKVVDTLYQKAKKLS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 23 | Phosphorylation | VNREEQDSSLLNKLV CCHHHHCHHHHHHHH | 29892262 | ||
| 24 | Phosphorylation | NREEQDSSLLNKLVR CHHHHCHHHHHHHHH | 19060867 | ||
| 298 | Phosphorylation | AEASHKRSLADFQAA HHHHHHHCHHHHHHH | 22817900 | ||
| 417 | Acetylation | VVDTLYQKAKKLS-- HHHHHHHHHHHCC-- | 21791702 | ||
| 434 (in isoform 2) | Acetylation | - | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PSD11_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PSD11_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PSD11_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CSN4_DROME | CSN4 | physical | 14605208 | |
| MS84C_DROME | Mst84Dc | physical | 14605208 | |
| PSMD1_DROME | Rpn2 | physical | 22036573 | |
| PSMD3_DROME | Rpn3 | physical | 22036573 | |
| ADRM1_DROME | Rpn13 | physical | 22036573 | |
| PSDE_DROME | Rpn11 | physical | 22036573 | |
| PSA1_DROME | Prosalpha6 | physical | 22036573 | |
| PSA4_DROME | Prosalpha3 | physical | 22036573 | |
| PSB4_DROME | Prosbeta7 | physical | 22036573 | |
| PSA2_DROME | Prosalpha2 | physical | 22036573 | |
| PSMD6_DROME | Rpn7 | physical | 22187461 | |
| PSMD7_DROME | Rpn8 | physical | 22187461 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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