PSA6_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSA6_DROME
• UniProt AC: Q9XZJ4
• Protein Name: Proteasome subunit alpha type-6
• Gene Name: Prosalpha1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 244
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)..
• Protein Sequence: MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAIAQENITTVALKSGDCAVVATQKKVTEKNIVPETVTHLFRITKDIGCAMTGRIADSRSQVQKARYEAANFRYKYGYEMPVDVLCRRIADINQVYTQNAEMRPLGCSMVLIAYDNEIGPSVYKTDPAGYFSGFKACSVGAKTLEANSYLEKKYKPNLSEEKAIQLAISCLSSVLAIDFKPNGIEIGVVSKSDPTFRILDEREIEEHLTKIAEKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	AGFDRHITIFSPEGR CCCCCEEEEECCCCC	15.16	19429919
17	Phosphorylation	DRHITIFSPEGRLYQ CCEEEEECCCCCEEE	20.42	19429919
27	Phosphorylation	GRLYQVEYAFKAIAQ CCEEEHHHHHHHHHH	20.62	19429919
74	Acetylation	THLFRITKDIGCAMT HHHHHHCCCCCHHHH	45.00	21791702
181	Acetylation	EANSYLEKKYKPNLS HHHHHHHHHHCCCCC	59.83	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSA6_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSA6_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSA6_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSA4_DROME	Prosalpha3	physical	22036573
PSA1_DROME	Prosalpha6	physical	22036573
PSB4_DROME	Prosbeta7	physical	22036573
PSA2_DROME	Prosalpha2	physical	22036573
SH3BG_DROME	Sh3beta	physical	22036573
EF1D_DROME	eEF1delta	physical	22036573
ADRM1_DROME	Rpn13	physical	22036573
PSMD1_DROME	Rpn2	physical	22036573
PSB2_DROME	Prosbeta4R2	physical	22036573
PSMF1_DROME	PI31	physical	23622245

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.