| UniProt ID | SIF2_DROME | |
|---|---|---|
| UniProt AC | P91620 | |
| Protein Name | Protein still life, isoforms C/SIF type 2 | |
| Gene Name | sif | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 2061 | |
| Subcellular Localization | Cell junction, synapse . Localizes to the submembranous region of synaptic terminals. | |
| Protein Description | Regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating Rho-like GTPases. Is likely a factor in the cascade of Rac1 or Cdc42 in the neurons.. | |
| Protein Sequence | MEQKCIRRKGSVRLTEPTGHAHVRIEQRPQLPPRRQKSAEEVATMPKSALRQPPEQLEWFDRRAQQRHSARSAEGGQVREETMEWLKLQKTASPIQPVRTSSGPSEITVLKDELPDWLLDHLPRKKERERDRLPSDADKAVGSAYAKALADLLKKPLSRQGSGPCEFSLLKTDIVEWLTKMQSSSGTDRGKSRRSHHRRNGSGGDAQPRSNSQEDAQDQSKTSHRKRHSLGHSGAVSEEEQQQLTADWIAYPLHKLQSLGKQPPPAQPPERMSIPSGYAVPSALSHTPLCQRREERSRERRLRHSASEVVGSGGAGAASTSNTAHLERLYAKPHKERYQYVPKTKESSGRKERSRRHQTQRSATVSDMSAQRSGGHKRKSSSAERAPRSPSPGPCTDPDCPLLPICTDPHCRYQECQARQCITSSVSSVNLARHQQLAQVQLHAVPAHLVGAMGSDVPTTPSTTATPPPPTGGGTMGVGATGAGAGATSERRLVICHDCRSCAPLLSCRNRKCLNAAKCNSLPRCAADFNRLRTQLSQPPTTLDDIEPAPLDDLEMQPLPSPPHPHPHHHYRSNSQPNTLQRGDSASSAGMGAGVGGAGHGGLGGPGSGLAWLEPTTTLVQPLPAYVHHSNGKLMKSASAASLNSRRRRHKTVHFGENLLREVCQNRKLIKTEAQVPSGSAPMKANIQMLYNFVEGVLSAWVDDDEDQVRSGAESEPEHGVVPMQPIHRCNRLRYQCIRRVVEEAADLQGTLKLGNSRYRHRHWRSTAKQCNEMFLRKISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHLLQEEIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVRVKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQVTGFCRSPQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGSPVWKPRDMINLGTDPQSTTRKDDVKN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 38 | Phosphorylation | LPPRRQKSAEEVATM CCCCCCCCHHHHHCC | 32.35 | 27794539 | |
| 38 (in isoform 1) | Phosphorylation | - | 32.35 | 27794539 | |
| 93 | Phosphorylation | LKLQKTASPIQPVRT HHHHCCCCCCCCCCC | 27.97 | 27794539 | |
| 93 (in isoform 1) | Phosphorylation | - | 27.97 | 27794539 | |
| 792 | Phosphorylation | MSLTTAVSDEDDGES CCCEEEEECCCCCCC | 32.58 | 27794539 | |
| 792 (in isoform 1) | Phosphorylation | - | 32.58 | 27794539 | |
| 1392 | Phosphorylation | QVTGFCRSPQETRKS HHHCCCCCHHHHCCC | 31.92 | 27794539 | |
| 1399 | Phosphorylation | SPQETRKSSPTGSVT CHHHHCCCCCCCCCC | 37.95 | 27794539 | |
| 1400 | Phosphorylation | PQETRKSSPTGSVTS HHHHCCCCCCCCCCC | 29.53 | 27794539 | |
| 1404 | Phosphorylation | RKSSPTGSVTSSVST CCCCCCCCCCCCCCC | 25.38 | 27794539 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SIF2_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SIF2_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SIF2_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| FAS2_DROME | Fas2 | genetic | 10976048 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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