G3P2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: G3P2_DROME
• UniProt AC: P07487
• Protein Name: Glyceraldehyde-3-phosphate dehydrogenase 2
• Gene Name: Gapdh2
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 332
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MSKIGINGFGRIGRLVLRAAIDKGANVVAVNDPFIDVNYMVYLFKFDSTHGRFKGTVAAEGGFLVVNGQKITVFSERDPANINWASAGAEYIVESTGVFTTIDKASTHLKGGAKKVIISAPSADAPMFVCGVNLDAYKPDMKVVSNASCTTNCLAPLAKVINDNFEIVEGLMTTVHATTATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKVIPALNGKLTGMAFRVPTPNVSVVDLTVRLGKGASYDEIKAKVQEAANGPLKGILGYTDEEVVSTDFLSDTHSSVFDAKAGISLNDKFVKLISWYDNEFGYSNRVIDLIKYMQSKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MSKIGINGFG -----CCCCCCCCCC	43.59	19608861
148	Phosphorylation	MKVVSNASCTTNCLA CEEECCCCCCCCCHH	19.08	21082442
150	Phosphorylation	VVSNASCTTNCLAPL EECCCCCCCCCHHHH	20.67	21082442
173	Phosphorylation	EIVEGLMTTVHATTA HHHHHHHHEEEEEEC	30.61	21082442
174	Phosphorylation	IVEGLMTTVHATTAT HHHHHHHEEEEEECC	9.06	21082442
178	Phosphorylation	LMTTVHATTATQKTV HHHEEEEEECCCCCC	11.33	21082442
181	Phosphorylation	TVHATTATQKTVDGP EEEEEECCCCCCCCC	28.62	21082442
191	Acetylation	TVDGPSGKLWRDGRG CCCCCCCCCCCCCCC	49.57	19608861
208	Phosphorylation	QNIIPASTGAAKAVG HHCCCCCCCHHHHHH	32.71	21082442
238	Phosphorylation	RVPTPNVSVVDLTVR ECCCCCEEEEEEEEE	24.06	22817900
256	Acetylation	GASYDEIKAKVQEAA CCCHHHHHHHHHHHH	39.86	21791702
273	Phosphorylation	PLKGILGYTDEEVVS CCCEECCCCCHHHEE	13.94	19060867
274	Phosphorylation	LKGILGYTDEEVVST CCEECCCCCHHHEEC	34.83	17379620

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of G3P2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of G3P2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of G3P2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MP20_DROME	Mp20	physical	22036573
GPDA_DROME	Gpdh	physical	22036573
LSP2_DROME	Lsp2	physical	22036573
VIT2_DROME	Yp2	physical	22036573
PGK_DROME	Pgk	physical	22036573
PYG_DROME	GlyP	physical	22036573
APLP_DROME	Rfabg	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-273 AND THR-274, ANDMASS SPECTROMETRY.
PubMed: 17372656