KL61_DROME - dbPTM
KL61_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KL61_DROME
UniProt AC P46863
Protein Name Kinesin-like protein Klp61F {ECO:0000303|PubMed:8227131}
Gene Name Klp61F {ECO:0000312|FlyBase:FBgn0004378}
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1066
Subcellular Localization Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm . In somatic cells, cytoplasmic during interphase, localized to centrosomal asters at the onset of mitosis in prophase and associated with spindle structures during
Protein Description Important role in mitotic dividing cells. [PubMed: 8227131 Microtubule motor required for spindle body separation]
Protein Sequence MDISGGNTSRQPQKKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHLFDELRMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVSMSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLGAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQKYEKETNENVGSVRVHHNQVEIICQESKQQLEAVQEKTEVNLEQMVDARQQLITEDRQRFIGHATVATDLVQESNRQFSEHAEHQRQQLQICEQELVRFQQSELKTYAPTGTTPSKRDFVYPRTLVATSPHQEIVRRYRQELDWSDLDTTATIDECSEGEHDVSMHSVQELSETETIMNSTPIEPVDGVTVKRGCGTTRNSNSNALKPPVATGGKRSSSLSRSLTPSKTSPRGSPAFVRHNKENVA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
189PhosphorylationDDSTKKGSVIIQGLE
ECCCCCCEEEEECCE		21.0121082442
282PhosphorylationKGIRVRETVNINQSL
CCCCEEEEEECCHHH		14.3221082442
461PhosphorylationTEENLLNTKGTLLLT
HHHHHCCCCCHHHHH		30.7121082442
464PhosphorylationNLLNTKGTLLLTKKV
HHCCCCCHHHHHHHH		18.7821082442
511PhosphorylationLAAADLATDDTHQLH
HHHHCCCCCCCCHHC		41.5319429919
514PhosphorylationADLATDDTHQLHGTI
HCCCCCCCCHHCHHH		17.8419429919
520PhosphorylationDTHQLHGTIERRREL
CCCHHCHHHHHHHHH		14.6619429919
534PhosphorylationLDEKIRRSCDQFKDR
HHHHHHHHHHHHHHH		16.5222817900
618PhosphorylationIGEVMKISDQHSQAF
HHHHHHCCHHHHHHH		26.2122817900
932PhosphorylationKTYAPTGTTPSKRDF
CCCCCCCCCCCCCCC		37.7028490779
933PhosphorylationTYAPTGTTPSKRDFV
CCCCCCCCCCCCCCC		27.2328490779
944PhosphorylationRDFVYPRTLVATSPH
CCCCCCCCEEECCHH		22.5327626673
948PhosphorylationYPRTLVATSPHQEIV
CCCCEEECCHHHHHH		35.0019429919
949PhosphorylationPRTLVATSPHQEIVR
CCCEEECCHHHHHHH		15.6219429919
1021PhosphorylationGCGTTRNSNSNALKP
CCCCCCCCCCCCCCC		38.0419429919
1023PhosphorylationGTTRNSNSNALKPPV
CCCCCCCCCCCCCCC		24.2519429919
1038PhosphorylationATGGKRSSSLSRSLT
CCCCCCCCCCCCCCC		39.0522817900
1043PhosphorylationRSSSLSRSLTPSKTS
CCCCCCCCCCCCCCC		32.9725749252
1045PhosphorylationSSLSRSLTPSKTSPR
CCCCCCCCCCCCCCC		27.1125749252
1047PhosphorylationLSRSLTPSKTSPRGS
CCCCCCCCCCCCCCC		43.2419429919
1049PhosphorylationRSLTPSKTSPRGSPA
CCCCCCCCCCCCCCC		48.5819429919
1050PhosphorylationSLTPSKTSPRGSPAF
CCCCCCCCCCCCCCC		19.1419429919
1054PhosphorylationSKTSPRGSPAFVRHN
CCCCCCCCCCCCCCC		17.8425749252
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KL61_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KL61_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KL61_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NCD_DROMEncdgenetic
15367580
FOJO_DROMEfjphysical
24114784
KL61_DROMEKlp61Fphysical
23299893
WARTS_DROMEwtsphysical
24114784
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KL61_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-933; SER-949; SER-1043;THR-1045; SER-1050 AND SER-1054, AND MASS SPECTROMETRY.
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-520 AND SER-949, ANDMASS SPECTROMETRY.

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