| UniProt ID | WARTS_DROME | |
|---|---|---|
| UniProt AC | Q9VA38 | |
| Protein Name | Serine/threonine-protein kinase Warts | |
| Gene Name | wts | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 1105 | |
| Subcellular Localization | Cytoplasm, cytosol . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with mats and cyclin E at the centrosome. | |
| Protein Description | Negative regulator of Yorkie (Yki) in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Inhibits nuclear localization of Yki. Regulates salivary gland degradation in a PI3K-dependent manner and Yki- and Sd-independent, mechanism.. | |
| Protein Sequence | MHPAGEKRGGRPNDKYTAEALESIKQDLTRFEVQNNHRNNQNYTPLRYTATNGRNDALTPDYHHAKQPMEPPPSASPAPDVVIPPPPAIVGQPGAGSISVSGVGVGVVGVANGRVPKMMTALMPNKLIRKPSIERDTASSHYLRCSPALDSGAGSSRSDSPHSHHTHQPSSRTVGNPGGNGGFSPSPSGFSEVAPPAPPPRNPTACSAATPPPPVPPTSQAYVKRRSPALNNRPPAIAPPTQRGNSPVITQNGLKNPQQQLTQQLKSLNLYPGGGSGAVVEPPPPYLIQGGAGGAAPPPPPPSYTASMQSRQSPTQSQQSDYRKSPSSGIYSATSAGSPSPITVSLPPAPLAKPQPRVYQARSQQPIIMQSVKSTQVQKPVLQTAVAPQSPSSASASNSPVHVLAAPPSYPQKSAAVVQQQQQAAAAAHQQQHQHQQSKPPTPTTPPLVGLNSKPNCLEPPSYAKSMQAKAATVVQQQQQQQQQQQQVQQQQVQQQQQQQQQQLQALRVLQAQAQRERDQRERDQRERERDQQKLANGNPGRQMLPPPPYQSNNNNNSEIKPPSCNNNNIQISNSNLATTPPIPPAKYNNNSSNTGANSSGGSNGSTGTTASSSTSCKKIKHASPIPERKKISKEKEEERKEFRIRQYSPQAFKFFMEQHIENVIKSYRQRTYRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATDLIRRLCASADKRLGKSVDEVKSHDFFKGIDFADMRKQKAPYIPEIKHPTDTSNFDPVDPEKLRSNDSTMSSGDDVDQNDRTFHGFFEFTFRRFFDDKQPPDMTDDQAPVYV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 132 | Phosphorylation | NKLIRKPSIERDTAS CCCCCCCCCCCCCCC | 39.87 | 22817900 | |
| 160 | Phosphorylation | AGSSRSDSPHSHHTH CCCCCCCCCCCCCCC | 26.26 | 22817900 | |
| 227 | Phosphorylation | QAYVKRRSPALNNRP HHHHHHCCHHHHCCC | 20.68 | 22817900 | |
| 246 | Phosphorylation | PPTQRGNSPVITQNG CCCCCCCCCCCCCCC | 24.30 | 21082442 | |
| 313 | Phosphorylation | ASMQSRQSPTQSQQS CCCCCCCCCCHHCCC | 28.89 | 21082442 | |
| 624 | Phosphorylation | CKKIKHASPIPERKK CCCCCCCCCCCHHHC | 24.07 | 19429919 | |
| 920 | Phosphorylation | HQRVLAHSLVGTPNY HHHHHHHHCCCCCCC | 21.10 | 21082442 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WARTS_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WARTS_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WARTS_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| YAP1_DROME | yki | physical | 19584286 | |
| AJUBA_DROME | jub | physical | 20303269 | |
| SCAL_DROME | sd | genetic | 18258485 | |
| SCAL_DROME | sd | genetic | 21078993 | |
| EXPA_DROME | ex | genetic | 16341207 | |
| EXPA_DROME | ex | genetic | 19289086 | |
| CAPZB_DROME | cpb | genetic | 23733343 | |
| CDK1_DROME | cdc2 | genetic | 9988268 | |
| SMUF1_DROME | lack | genetic | 25450375 | |
| YAP1_DROME | yki | genetic | 21078993 | |
| CCNA_DROME | CycA | genetic | 9988268 | |
| MOB1_DROME | mats | genetic | 15766530 | |
| MNB_DROME | mnb | physical | 23955303 | |
| MERH_DROME | Mer | physical | 24012335 | |
| EXPA_DROME | ex | physical | 26420589 | |
| SRRT_DROME | Ars2 | physical | 24114784 | |
| CATL_DROME | Cp1 | physical | 24114784 | |
| HIPPO_DROME | hpo | physical | 14561774 | |
| YAP1_DROME | yki | physical | 24114784 | |
| YAP1_DROME | yki | physical | 16096061 | |
| KL61_DROME | Klp61F | physical | 24114784 | |
| MY61F_DROME | Myo61F | physical | 24114784 | |
| ACADM_DROME | CG12262 | physical | 24114784 | |
| MOB1_DROME | mats | physical | 24114784 | |
| MOB1_DROME | mats | physical | 15766530 | |
| MOB1_DROME | mats | physical | 19913529 | |
| MOB1_DROME | mats | physical | 24012335 | |
| MYS9_DROME | jar | physical | 24114784 | |
| ATC1_DROME | Ca-P60A | physical | 24114784 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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