HIPPO_DROME - dbPTM
HIPPO_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HIPPO_DROME
UniProt AC Q8T0S6
Protein Name Serine/threonine-protein kinase hippo
Gene Name hpo
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 669
Subcellular Localization Apical cell membrane . Cytoplasm .
Protein Description Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Phosphorylates Sav, Wts and Th/DIAP1. Regulates the level of Th/DIAP1 apoptosis inhibitor..
Protein Sequence MSEPEVTSVVDMKSPNISSSCSFFKLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILKPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHITDNAFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLSKAAAPAAASSAASPLDMPAVDSGTMVELESNLGTMVINSDSDDSTTAKNNDDQKPRNRYRPQFLEHFDRKNAGDGRGDEKPIATEYSPAAAEQQQQQQQQQQQQQQDEQHLASGANDLNNWEHNMEMQFQQISAINQYGLQQHQQQQQVLMAYPLMNEQLIALNNQPNLLLSNAAPMGQQGIPAAAPAQPPPAYQNQHMHTQSHAYVEGEFEFLKFLTFDDLNQRLCNIDHEMELEIEQLNKKYNAKRQPIVDAMNAKRKRQQNINNNLIKI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
14PhosphorylationTSVVDMKSPNISSSC
CEEECCCCCCCCCCC
19.2819429919
20PhosphorylationKSPNISSSCSFFKLK
CCCCCCCCCCCEECC
13.6421082442
22PhosphorylationPNISSSCSFFKLKKL
CCCCCCCCCEECCCC
35.3522817900
30PhosphorylationFFKLKKLSEESLLQP
CEECCCCCHHHHCCC
48.4722817900
33PhosphorylationLKKLSEESLLQPPEK
CCCCCHHHHCCCCHH
30.2622817900
52PhosphorylationMYKLGEGSYGSVYKA
HHCCCCCCCHHHHHH
23.2425749252
53PhosphorylationYKLGEGSYGSVYKAV
HCCCCCCCHHHHHHH
25.0325749252
55PhosphorylationLGEGSYGSVYKAVHK
CCCCCCHHHHHHHHC
17.6525749252
195PhosphorylationDTMAKRNTVIGTPFW
HCHHHHCCCCCCCCC
19.9612941273
321PhosphorylationEQQRANRSFGGVLAA
HHHHHHHCHHHHHHH
28.2219429919
329PhosphorylationFGGVLAASQAKSLAT
HHHHHHHHHHHHHHH
25.6821082442
356PhosphorylationAFMEDPGTLVPEKFG
CCCCCCCCCCCHHHC
29.9421082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
195TPhosphorylationKinaseTAOQ0KHQ5
Uniprot

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HIPPO_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HIPPO_DROME !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SAV_DROMEsavphysical
14605208
DEFI8_DROMECG11534physical
14605208
FBXW7_DROMEagophysical
14605208
RS20_DROMERpS20physical
14605208
MODU_DROMEmodphysical
14605208
Y678_DROMECG2678physical
14605208
EF1D_DROMEeEF1deltaphysical
14605208
GBLP_DROMERack1physical
14605208
L259_DROMEl(2)03659physical
14605208
SAV_DROMEsavphysical
15710747
DISC_DROMEdiscophysical
15710747
EXPA_DROMEexphysical
15710747
RS18_DROMERpS18physical
15710747
TRR_DROMEtrrgenetic
25027438
SCAL_DROMEsdgenetic
18258485
DOME_DROMEdomegenetic
21078993
BUN1_DROMEbungenetic
26323255
BUN2_DROMEbungenetic
26323255
ENA_DROMEenagenetic
23733343
EGFR_DROMEEgfrgenetic
21078993
YAP1_DROMEykigenetic
16096061
YAP1_DROMEykigenetic
17974916
YAP1_DROMEykigenetic
18256197
YAP1_DROMEykigenetic
21078993
YAP1_DROMEykigenetic
22555454
DRONC_DROMENcgenetic
22555454
BRM_DROMEbrmgenetic
24137538
DIAP1_DROMEthgenetic
14502294
HID_DROMEWgenetic
14502294
TRC_DROMEtrcgenetic
16906135
NRBP_DROMEMadmgenetic
26323255
WARTS_DROMEwtsgenetic
12941273
WARTS_DROMEwtsgenetic
14561774
WARTS_DROMEwtsgenetic
14502294
WARTS_DROMEwtsgenetic
16341207
WARTS_DROMEwtsgenetic
24012335
SAV_DROMEsavgenetic
12941273
SAV_DROMEsavphysical
20797625
SAV_DROMEsavphysical
24114784
SAV_DROMEsavphysical
25484297
SAV_DROMEsavphysical
12941273
SAV_DROMEsavphysical
14502295
SAV_DROMEsavphysical
14561774
SAV_DROMEsavphysical
17174922
SAV_DROMEsavphysical
22069188
SAV_DROMEsavphysical
22215676
SAV_DROMEsavphysical
26403189
2AAA_DROMEPp2A-29Bphysical
20797625
MERH_DROMEMerphysical
22069188
EXPA_DROMEexphysical
22069188
DS_DROMEdsphysical
24114784
FGOP2_DROMECG10158physical
20797625
MOB4_DROMEMob4physical
20797625
HIPPO_DROMEhpophysical
14502294
HIPPO_DROMEhpophysical
22215676
HIPPO_DROMEhpophysical
12941273
HIPPO_DROMEhpophysical
14502295
HIPPO_DROMEhpophysical
23263283
HIPPO_DROMEhpophysical
23298890
RS18_DROMERpS18physical
24114784
YAP1_DROMEykiphysical
25484297
YAP1_DROMEykiphysical
19733165
DIAP1_DROMEthphysical
12941274
DIAP1_DROMEthphysical
14502295
ARF1_DROMEArf79Fphysical
24114784
MOB1_DROMEmatsphysical
22215676
WARTS_DROMEwtsphysical
14502295
WARTS_DROMEwtsphysical
19733165
WARTS_DROMEwtsphysical
26403189
WARTS_DROMEwtsphysical
12941273
WARTS_DROMEwtsphysical
24012335
RAN_DROMERanphysical
24114784
PP2A_DROMEmtsphysical
20797625
ATC1_DROMECa-P60Aphysical
24114784

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HIPPO_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30 AND SER-33, AND MASSSPECTROMETRY.

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