UniProt ID | HIPPO_DROME | |
---|---|---|
UniProt AC | Q8T0S6 | |
Protein Name | Serine/threonine-protein kinase hippo | |
Gene Name | hpo | |
Organism | Drosophila melanogaster (Fruit fly). | |
Sequence Length | 669 | |
Subcellular Localization | Apical cell membrane . Cytoplasm . | |
Protein Description | Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Phosphorylates Sav, Wts and Th/DIAP1. Regulates the level of Th/DIAP1 apoptosis inhibitor.. | |
Protein Sequence | MSEPEVTSVVDMKSPNISSSCSFFKLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILKPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHITDNAFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLSKAAAPAAASSAASPLDMPAVDSGTMVELESNLGTMVINSDSDDSTTAKNNDDQKPRNRYRPQFLEHFDRKNAGDGRGDEKPIATEYSPAAAEQQQQQQQQQQQQQQDEQHLASGANDLNNWEHNMEMQFQQISAINQYGLQQHQQQQQVLMAYPLMNEQLIALNNQPNLLLSNAAPMGQQGIPAAAPAQPPPAYQNQHMHTQSHAYVEGEFEFLKFLTFDDLNQRLCNIDHEMELEIEQLNKKYNAKRQPIVDAMNAKRKRQQNINNNLIKI | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
14 | Phosphorylation | TSVVDMKSPNISSSC CEEECCCCCCCCCCC | 19.28 | 19429919 | |
20 | Phosphorylation | KSPNISSSCSFFKLK CCCCCCCCCCCEECC | 13.64 | 21082442 | |
22 | Phosphorylation | PNISSSCSFFKLKKL CCCCCCCCCEECCCC | 35.35 | 22817900 | |
30 | Phosphorylation | FFKLKKLSEESLLQP CEECCCCCHHHHCCC | 48.47 | 22817900 | |
33 | Phosphorylation | LKKLSEESLLQPPEK CCCCCHHHHCCCCHH | 30.26 | 22817900 | |
52 | Phosphorylation | MYKLGEGSYGSVYKA HHCCCCCCCHHHHHH | 23.24 | 25749252 | |
53 | Phosphorylation | YKLGEGSYGSVYKAV HCCCCCCCHHHHHHH | 25.03 | 25749252 | |
55 | Phosphorylation | LGEGSYGSVYKAVHK CCCCCCHHHHHHHHC | 17.65 | 25749252 | |
195 | Phosphorylation | DTMAKRNTVIGTPFW HCHHHHCCCCCCCCC | 19.96 | 12941273 | |
321 | Phosphorylation | EQQRANRSFGGVLAA HHHHHHHCHHHHHHH | 28.22 | 19429919 | |
329 | Phosphorylation | FGGVLAASQAKSLAT HHHHHHHHHHHHHHH | 25.68 | 21082442 | |
356 | Phosphorylation | AFMEDPGTLVPEKFG CCCCCCCCCCCHHHC | 29.94 | 21082442 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
195 | T | Phosphorylation | Kinase | TAO | Q0KHQ5 | Uniprot |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HIPPO_DROME !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HIPPO_DROME !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30 AND SER-33, AND MASSSPECTROMETRY. |