DOME_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DOME_DROME
• UniProt AC: Q9VWE0
• Protein Name: Cytokine receptor
• Gene Name: dome
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1282
• Subcellular Localization: Apicolateral cell membrane ; Single-pass type I membrane protein . Apicolateral membranes in follical cells.
• Protein Description: Critical for epithelial morphogenesis during oogenesis; border cell migration. Required in the germarium for the polarization of follicle cells during encapsulation of germline cells. Required for embryonic segmentation and trachea specification. Essential receptor molecule for upd and JAK/STAT signaling during oogenesis..
• Protein Sequence: MVAQEQLVLLLMLLAGCRGGANAILDPGWVIPSKVEQLIGGDFNLSCTLNEDYFNGKSAEDCPVEKLYFTGGGRVYRDSKHIRILNNTTILFSDTNAVEQENDYHCMCDEYVINKSKVYVGTRPLLVRDFNCLDYDFQFMVCNFTQPPNTVITKYNISYNTNNDWRYSNTLDCNFDSAPVVTCNLTDDNYKRFSETFYFRLSISNALGHETQPITINHFERLVPARPGQNLTLLNRTESSVCLSWEMPRRSNYNRGLVWQVRVTPQNFEPITRPSWRNHTLTIKDTLCLTELPFAGYNYTLRVRVRANQNNTLWSEPMIYAFATAPAPPRRPPRVTYGSFYVYSSEKAMRFYWEPLEEHELNGPDFRYSISEYRINGTAVDPGLIKVESNSAMIDHWSMSAVHHFLIRSSNSQGLSVNATPMTIGPISNRDFKVREPRNIRSVYHPTNKSYTLSWDPPSDQRELQNYTVFWCVPKPGLQSECEGSIRFAEVASGLHHFTTSPDQLLTLHMAVSANYQSHNTGLHWAICSSDKKDDLAKMEPSIDVATSTSLTVSWSERVCAVILAGYNLTYCQRSAGRPDNCTTVTIDRYTNKHVIQNLVPYTDYSVKMLMYSDSRVSKYSDELVNRTGEAAPSQPRELQLIRVTSDSVELAWKPPLLANGVVRAYEGTFRSLHDNVTDTFRVSASADELVNNEKPITYRLGNLTAFTKYEISVRARTVYPSEPSNVILFSTAIGVPSPPQLYVINNPDQSSRLDWEPPRTPAGRIDFYEISLRDNNASCLTSTILPGRNLSYVMATPRCTSHNPFQLAVRAINVEQHPQLNGADAAEGAVLLMSTNGKGCEARTDALGEEERLQFEAYAANMTAYRLYRSDWGIYGFICTPDTHSVKAMYQTIEVTVAILVLGVIFYLVYKKYRKMSDIGLVLPQGIMETMKKPIDMGGLGLGLGPDSSVSGGIVCTRVDDSPPYTPQDLPHDFSSCGSESSKLLLRTASSSGGGGCVDRDGYDDNHETGPISAVGPPTSYLAMRHGLLVQNDRERERERDREQEREREQQQQQRESEMDREQSCTNGYIKPTQMKSWGGNGPSDNDHTFSVPSTAMTAPMSQPLSQIPLSGYVPVPIPQSRFNPAPVQPFGSPAVPSAATAAAASTFFPPAHLLNMDNYVQASDLHKLKPLVAAPLSQTGGPAFAGSSPATSPPLQLPPVHAASPAAATPKMADIGYTTMEQLQLTGLIKPPLAATVGSPTHAAGGAPGGGNQHSRLQPQINGYVTPQDLNAMAHNRHVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	N-linked_Glycosylation	QLIGGDFNLSCTLNE HHHCCCCEEEEECCC	35.47	-
86	N-linked_Glycosylation	SKHIRILNNTTILFS CCCEEEECCCEEEEC	41.24	-
87	N-linked_Glycosylation	KHIRILNNTTILFSD CCEEEECCCEEEECC	34.84	-
114	N-linked_Glycosylation	MCDEYVINKSKVYVG CEEEEEEECCCEEEC	32.29	-
143	N-linked_Glycosylation	DFQFMVCNFTQPPNT EEEEEEECCCCCCCE	31.43	-
156	N-linked_Glycosylation	NTVITKYNISYNTNN CEEEEEEEEEEECCC	20.48	-
184	N-linked_Glycosylation	SAPVVTCNLTDDNYK CCCEEEEECCCCCCC	36.29	-
230	N-linked_Glycosylation	VPARPGQNLTLLNRT CCCCCCCCEEECCCC	40.69	-
235	N-linked_Glycosylation	GQNLTLLNRTESSVC CCCEEECCCCCCCEE	52.52	-
278	N-linked_Glycosylation	ITRPSWRNHTLTIKD CCCCHHHCCEEEEEC	26.66	-
298	N-linked_Glycosylation	ELPFAGYNYTLRVRV ECCCCCCEEEEEEEE	23.54	-
310	N-linked_Glycosylation	VRVRANQNNTLWSEP EEEEECCCCCCCCCC	43.17	-
376	N-linked_Glycosylation	SISEYRINGTAVDPG EEEEEEECCEECCCC	32.53	-
448	N-linked_Glycosylation	RSVYHPTNKSYTLSW CCEECCCCCCEEEEC	35.41	-
466	N-linked_Glycosylation	SDQRELQNYTVFWCV CCHHHHCCEEEEEEE	47.25	-
568	N-linked_Glycosylation	AVILAGYNLTYCQRS HHHHCCCCEEEEHHH	25.62	-
581	N-linked_Glycosylation	RSAGRPDNCTTVTID HHCCCCCCCEEEEEE	27.93	-
626	N-linked_Glycosylation	KYSDELVNRTGEAAP HHHHHHHHHCCCCCC	48.71	-
676	N-linked_Glycosylation	TFRSLHDNVTDTFRV CCHHHCCCCCCEEEE	28.04	-
703	N-linked_Glycosylation	PITYRLGNLTAFTKY CCEEEECCCEEEEEE	38.52	-
777	N-linked_Glycosylation	EISLRDNNASCLTST EEEECCCCCCCEEEE	37.20	-
790	N-linked_Glycosylation	STILPGRNLSYVMAT EEECCCCCEEEEEEC	38.97	-
862	N-linked_Glycosylation	QFEAYAANMTAYRLY HHHHHHHHCHHHHHH	21.84	-
976	Phosphorylation	QDLPHDFSSCGSESS CCCCCCHHHCCCHHH	30.67	22817900
1067	Phosphorylation	MDREQSCTNGYIKPT HHHHHHHCCCCCCCC	36.60	22668510
1070	Phosphorylation	EQSCTNGYIKPTQMK HHHHCCCCCCCCCCC	14.08	22668510

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DOME_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DOME_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DOME_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JAK_DROME	hop	genetic	11696329
JAK_DROME	hop	genetic	11825879
EGFR_DROME	Egfr	genetic	21176204
RAS1_DROME	Ras85D	genetic	21176204
STAT_DROME	Stat92E	genetic	11696329
STAT_DROME	Stat92E	genetic	12403714
JAK_DROME	hop	physical	20624926
JAK_DROME	hop	physical	26658615
DOME_DROME	dome	physical	26658615
STAT_DROME	Stat92E	physical	26658615

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-976, AND MASSSPECTROMETRY.
PubMed: 18327897