JAK_DROME - dbPTM
JAK_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID JAK_DROME
UniProt AC Q24592
Protein Name Tyrosine-protein kinase hopscotch
Gene Name hop
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1177
Subcellular Localization Endomembrane system
Peripheral membrane protein. Wholly intracellular, possibly membrane associated..
Protein Description Tyrosine kinase of the non-receptor type, phosphorylates the marelle protein. Required maternally for the establishment of the normal array of embryonic segments: involved in the control of pair-rule gene transcription in a stripe-specific manner. Together with Hsp83 and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation..
Protein Sequence MALANGGEDRMDDSSSGRTSLADSASLTNSSLRSGTSSQSIHTNDGTIRVFNFTTGEFERFHPNMLCEEICNTMCRQLGIAPIAQLLYGIREHSTSRRPSPLVRLDLTWCLPGERLNCQLVYCFRMRFRVPELDSQLELIDGRSHKFLYRQMRYDMRTEQIPEIRYPEHKDKSTGLAVMDMLIDDQEQSEDQQAMRSIEKLYKLYLPPSLWRAHSFFVGSKIREVFRSLKANSLSVERLKWHYVHQVSHLAPTYMTEQFTCTVQYLPNEEVARGSGPIGTSLAHSTSTLASSGSTNTLSTLTTNTNSVALGGSGKKAKRRSTSGGIDVYVRVFPHDSLEPGLKVARVTSEATLKWILVGAVEGIFMISKINDTSVRLEIVGLPKGYEMQFQTEKEMKSFISYLGIYIRLSSKWMQDLCHSYRTPSLEELSSLHCHGPIGGAYSLMKLHENGDKCGSYIVRECDREYNIYYIDINTKIMAKKTDQERCKTETFRIVRKDSQWKLSYNNGEHVLNSLHEVAHIIQADSPDRYRIPASKYDKPPLLLLLLPKNLKAKKTDLQLSEAELQRRNPQIFNPRTDLQWYPDSISLSDDGMMFTMRGDWIQQSPVKDVSVTMKMLKSDGNFMEFFRLAQTWSLIQSPQFLKLYGLTLADPYTMVMEYSRYGPLNKFLHSMPNVTLHCLLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKYDPNSYVLDAKISDPGYPRPYRESDSPWIPVKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDICPAPIFETIMDGWSDDETKRFSHHDIFSRLNTIKAEILPNYMPPPEIATNGTGDETVIDRSDIPFLPFPRSNMLMVIPLTSECRVIYNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVSTDFHREIGIMRTLSHPNIVKFKYWAEKSHCIIMEYLQSGSFDIYLRFTAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIVDIITREVATKVTHPTDGHQSPPNQPTDAE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
37PhosphorylationSSLRSGTSSQSIHTN
CCCCCCCCCCEEECC		29.8822817900
40PhosphorylationRSGTSSQSIHTNDGT
CCCCCCCEEECCCCE		20.4822817900
321PhosphorylationGKKAKRRSTSGGIDV
CCCCCCCCCCCCCEE		30.8418327897
1047PhosphorylationQFANSDGYYYAKSKR
EEECCCCCEEECCCC		9.78-
1048PhosphorylationFANSDGYYYAKSKRD
EECCCCCEEECCCCC		11.50-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of JAK_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of JAK_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of JAK_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KRAF1_DROMEphlgenetic
11919715
DSOR1_DROMEDsor1genetic
11919715
USH_DROMEushgenetic
24163435
USH_DROMEushgenetic
17936744
CCNE_DROMECycEgenetic
12586062
RHO1_DROMERho1genetic
24163435
PTP61_DROMEPtp61Fgenetic
16094372
ECD_DROMEecdgenetic
11846478
BRM_DROMEbrmgenetic
12454071
GNAF_DROMEGalphafgenetic
24163435
GNAF_DROMEGalphafgenetic
20168330
STAT_DROMEStat92Egenetic
8608595
STAT_DROMEStat92Egenetic
8608596
STAT_DROMEStat92Egenetic
8650180
STAT_DROMEStat92Egenetic
9032284
STAT_DROMEStat92Egenetic
12454071
STAT_DROMEStat92Egenetic
16094372
STAT_DROMEStat92Egenetic
20168330
STAT_DROMEStat92Egenetic
24163435
NDKA_DROMEawdgenetic
8394175
PPO3_DROMEPPO3genetic
18852525
NU301_DROMEE(bx)genetic
12502740
NU301_DROMEE(bx)genetic
21385730
FOSLD_DROMEkaygenetic
19641625
FOSLA_DROMEkaygenetic
19641625
STAT_DROMEStat92Ephysical
27194748
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of JAK_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40 AND SER-321, AND MASSSPECTROMETRY.

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