dbPTM

DSOR1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DSOR1_DROME
UniProt AC	Q24324
Protein Name	Dual specificity mitogen-activated protein kinase kinase dSOR1
Gene Name	Dsor1
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	396
Subcellular Localization
Protein Description	Required downstream of Raf in the sevenless (sev), torso (tor), and Drosophila EGF receptor homolog (DER) signal transduction pathways. Involved in both positive regulation (at the posterior terminus) and negative regulation (at the anterior domain) of tll, as in other terminal class gene products, maybe via the ERK-A kinase..
Protein Sequence	MSKNKLNLVLPPVNTEATVAAATVAPTPPFKTPSGTDTHSLLGKPKTSIDALTETLEGLDMGDTERKRIKMFLSQKEKIGELSDEDLEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPNTATLESIFADNAEESGQPTDEPRAMAIFELLDYIVNEPPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWIRKAELEEVDISGWVCKTMDLPPSTPKRNTSPN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	AAATVAPTPPFKTPS EEEEECCCCCCCCCC	33.58	21082442
47	Phosphorylation	SLLGKPKTSIDALTE HHCCCCCCCHHHHHH	39.17	19429919
48	Phosphorylation	LLGKPKTSIDALTET HCCCCCCCHHHHHHH	25.29	22817900
237	Phosphorylation	VSGQLIDSMANSFVG CCHHHHHHHHHHCCC	16.89	29433126
241	Phosphorylation	LIDSMANSFVGTRSY HHHHHHHHCCCCCCC	16.27	29433126
387	Phosphorylation	KTMDLPPSTPKRNTS ECCCCCCCCCCCCCC	56.24	27794539
388	Phosphorylation	TMDLPPSTPKRNTSP CCCCCCCCCCCCCCC	38.31	27626673

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
237	S	Phosphorylation	Kinase	RAF	P11346	Uniprot
241	S	Phosphorylation	Kinase	RAF	P11346	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DSOR1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DSOR1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VRET_DROME	vret	physical	22036573
POK_DROME	aop	genetic	8722784
SRC42_DROME	Src42A	genetic	8013459
SRC42_DROME	Src42A	genetic	10075855
MAM_DROME	mam	genetic	8722784
EGFR_DROME	Egfr	genetic	9927462
TAF6_DROME	Taf6	genetic	8722784
HH_DROME	hh	genetic	8722784
PNT1_DROME	pnt	genetic	8033205
PNT2_DROME	pnt	genetic	8033205
PP2A_DROME	mts	genetic	8722784
ERKA_DROME	rl	genetic	8722784
ERKA_DROME	rl	genetic	9927462
ERKA_DROME	rl	genetic	10511556
ARM_DROME	arm	physical	26542023
KRAF1_DROME	phl	physical	22028469
RS28_DROME	RpS28b	physical	22028469
ADT_DROME	sesB	physical	22028469
CAZ_DROME	caz	physical	22028469
COPB_DROME	betaCOP	physical	22028469
PRS8_DROME	Rpt6	physical	22028469
ERKA_DROME	rl	physical	20802461
ERKA_DROME	rl	physical	26542023
RL15_DROME	RpL15	physical	22028469
RS2_DROME	RpS2	physical	22028469
RL9_DROME	RpL9	physical	22028469
RL24_DROME	RpL24	physical	22028469
1433Z_DROME	14-3-3zeta	physical	22028469
CAPZA_DROME	cpa	physical	22028469
HSP83_DROME	Hsp83	physical	22028469
RL28_DROME	RpL28	physical	22028469
RFC2_DROME	RfC4	physical	22028469
HDAC1_DROME	Rpd3	physical	22028469
UBP36_DROME	scny	physical	22028469
ACADM_DROME	CG12262	physical	22028469
MCM7_DROME	Mcm7	physical	22028469
EIF3L_DROME	CG5642	physical	22028469
BRM_DROME	brm	physical	22028469
EIF3A_DROME	eIF3-S10	physical	22028469
GMPPB_DROME	CG1129	physical	22028469
TBA3_DROME	alphaTub84D	physical	22028469
SQD_DROME	sqd	physical	22028469
1433E_DROME	14-3-3epsilon	physical	22028469
RS20_DROME	RpS20	physical	22028469
KPYK_DROME	PyK	physical	22028469
RL32_DROME	RpL32	physical	22028469
RL10_DROME	RpL10	physical	22028469
IF4E_DROME	eIF-4E	physical	22028469
CSN8_DROME	CSN8	physical	22028469
ATC1_DROME	Ca-P60A	physical	22028469
LARP_DROME	larp	physical	22028469

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DSOR1_DROME

Related Literatures of Post-Translational Modification