UBP36_DROME - dbPTM
UBP36_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UBP36_DROME
UniProt AC Q9VRP5
Protein Name Ubiquitin carboxyl-terminal hydrolase 36
Gene Name scny
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1038
Subcellular Localization Nucleus, nucleolus .
Protein Description Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Controls selective autophagy activation by ubiquitinated proteins. [PubMed: 22622177]
Protein Sequence MPVSMAVCETANVVNAALRESLGGNSSAGSSTDQAKSGEDTNGSLQNHIVANAKRILMAKIEYEEVPNYHESVLENLKSKYIVIKPGNPGAINGFSGKNNTGKLVGANGHDNNGARKQAEHPNNQSHHINHHNHQHPTSNPNELPKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLADCNVAEPGSGCIICAMTKTLLATQSNQSAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADSLEDAFEGHFSRERLEDMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFSMIGNKLTKQISFKSRIDLSKYAARSQAAQAQPLTYRLVSMVTHLGASQHCGHYTAIGSTDTGSFYNFDDSYVRPIAMHSVCNTNAYIMFFELDLSQAASPAANRPNGVRLTNGHSTTPVPAATVSSPSPTRFIGPQLPAGGANGYTNGNAQKTAIQFKQQNQQSPQNGLQLGTGKFQDTAKPPLVGAHAKGEATSAPTANGNKSSSPSSNSSSNHKSINQQQYLPISSDDEDIEDEMKPRPTTAQLPSMPNMTENHTEPKAKSPVKIQVKTPVKTPLKSLVPYESASEEEEAPLPNPRKRPSGEDSSESDQESGQTNGHSKTNGSHTNGSASSSVHVNNSKQKTDAIDEIFKSLKKSADSDEDDDEEEPSIQLTNGWHPQKQSQSQSKAPPSPKTPPSPAVIKSKTGIWKVTRNDEVDAIEDDVDVVVVEGSPVKIPTPNKNHRNPFSSSKPSTDSPATPGAKRQKLLNGSALKSHQQPRVGNGYQSNATSNGSTINELLKQSYRGYGSPVLSWNGKPAELEKELLVDAREQRQRDIDDDEENEMDRGRQRKVKSGSAKGNNASNSTPGYNPFQEYEGQKRWNKNGGGGGFPRFYNQNYRQNFQQRNKFKFNRFGGPGSAKFQQQRALQRHLSAGGGFSRRQPSAQQQQQT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
510PhosphorylationTTPVPAATVSSPSPT
CCCCCCCCCCCCCCC		24.0319429919
512PhosphorylationPVPAATVSSPSPTRF
CCCCCCCCCCCCCCE		31.9819429919
513PhosphorylationVPAATVSSPSPTRFI
CCCCCCCCCCCCCEE		25.6819429919
515PhosphorylationAATVSSPSPTRFIGP
CCCCCCCCCCCEECC		40.6319429919
517PhosphorylationTVSSPSPTRFIGPQL
CCCCCCCCCEECCCC		42.4219429919
551PhosphorylationFKQQNQQSPQNGLQL
HHHHHCCCCCCCCCC		20.7730478224
614PhosphorylationQQQYLPISSDDEDIE
HHHCCCCCCCCCCCC		26.2719429919
615PhosphorylationQQYLPISSDDEDIED
HHCCCCCCCCCCCCH		50.2119429919
650PhosphorylationHTEPKAKSPVKIQVK
CCCCCCCCCCEEEEE		39.5222668510
658PhosphorylationPVKIQVKTPVKTPLK
CCEEEEECCCCCCHH		34.1619429919
662PhosphorylationQVKTPVKTPLKSLVP
EEECCCCCCHHHCCC		33.8029892262
666PhosphorylationPVKTPLKSLVPYESA
CCCCCHHHCCCCCCC		42.1319429919
670PhosphorylationPLKSLVPYESASEEE
CHHHCCCCCCCCCCC		18.2919429919
672PhosphorylationKSLVPYESASEEEEA
HHCCCCCCCCCCCCC		31.1119429919
674PhosphorylationLVPYESASEEEEAPL
CCCCCCCCCCCCCCC		55.6219429919
689PhosphorylationPNPRKRPSGEDSSES
CCCCCCCCCCCCCHH		59.8719429919
693PhosphorylationKRPSGEDSSESDQES
CCCCCCCCCHHHHCC		31.5319429919
694PhosphorylationRPSGEDSSESDQESG
CCCCCCCCHHHHCCC		54.1419429919
696PhosphorylationSGEDSSESDQESGQT
CCCCCCHHHHCCCCC		46.6819429919
700PhosphorylationSSESDQESGQTNGHS
CCHHHHCCCCCCCCC		30.4819429919
703PhosphorylationSDQESGQTNGHSKTN
HHHCCCCCCCCCCCC		46.8519429919
707PhosphorylationSGQTNGHSKTNGSHT
CCCCCCCCCCCCCCC		42.4419429919
744PhosphorylationIFKSLKKSADSDEDD
HHHHHHHHCCCCCCC		35.4019429919
747PhosphorylationSLKKSADSDEDDDEE
HHHHHCCCCCCCCCC		42.4919429919
779PhosphorylationSQSKAPPSPKTPPSP
CCCCCCCCCCCCCCC		37.6619429919
782PhosphorylationKAPPSPKTPPSPAVI
CCCCCCCCCCCCCEE		43.7619429919
785PhosphorylationPSPKTPPSPAVIKSK
CCCCCCCCCCEEECC		27.0519429919
819PhosphorylationDVVVVEGSPVKIPTP
CEEEECCCEEECCCC		17.0230478224
825PhosphorylationGSPVKIPTPNKNHRN
CCEEECCCCCCCCCC		42.8630478224
843PhosphorylationSSKPSTDSPATPGAK
CCCCCCCCCCCCCHH		19.2730478224
846PhosphorylationPSTDSPATPGAKRQK
CCCCCCCCCCHHHHH		26.1619060867
896PhosphorylationQSYRGYGSPVLSWNG
HHHCCCCCCCCCCCC		11.8919429919
1020PhosphorylationRALQRHLSAGGGFSR
HHHHHHHHCCCCCCC		37.4219429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UBP36_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UBP36_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UBP36_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DIAP1_DROMEthgenetic
19217892
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UBP36_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-513; SER-515; THR-658;THR-662; SER-672; SER-674; SER-747; SER-779; THR-782; SER-785;SER-819; THR-825; SER-843 AND THR-846, AND MASS SPECTROMETRY.

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