| UniProt ID | SQD_DROME | |
|---|---|---|
| UniProt AC | Q08473 | |
| Protein Name | RNA-binding protein squid | |
| Gene Name | sqd | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 344 | |
| Subcellular Localization | Nucleus . Cytoplasm . It is possible that some isoforms are found only in one of these locations. | |
| Protein Description | This protein is a component of ribonucleosomes. Could be needed to organize a concentration gradient of a dorsalizing morphogen (Dm) originating in the germinal vesicle. At least one of the isoforms is essential in somatic tissues.. | |
| Protein Sequence | MAENKQVDTEINGEDFTKDVTADGPGSENGDAGAAGSTNGSSDNQSAASGQRDDDRKLFVGGLSWETTEKELRDHFGKYGEIESINVKTDPQTGRSRGFAFIVFTNTEAIDKVSAADEHIINSKKVDPKKAKARHGKIFVGGLTTEISDEEIKTYFGQFGNIVEVEMPFDKQKSQRKGFCFITFDSEQVVTDLLKTPKQKIAGKEVDVKRATPKPENQMMGGMRGGPRGGMRGGRGGYGGRGGYNNQWDGQGSYGGYGGGYGGYGAGGYGDYYAGGYYNGYDYGYDGYGYGGGFEGNGYGGGGGGNMGGGRGGPRGGGGPKGGGGFNGGKQRGGGGRQQRHQPY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | AENKQVDTEINGEDF CCCCCCCCEECCCCC | 39.65 | 22668510 | |
| 17 | Phosphorylation | EINGEDFTKDVTADG EECCCCCCCCCCCCC | 38.36 | 22668510 | |
| 21 | Phosphorylation | EDFTKDVTADGPGSE CCCCCCCCCCCCCCC | 29.21 | 22668510 | |
| 27 | Phosphorylation | VTADGPGSENGDAGA CCCCCCCCCCCCCCC | 30.90 | 19429919 | |
| 37 | Phosphorylation | GDAGAAGSTNGSSDN CCCCCCCCCCCCCCC | 17.61 | 22817900 | |
| 38 | Phosphorylation | DAGAAGSTNGSSDNQ CCCCCCCCCCCCCCC | 42.56 | 22817900 | |
| 41 | Phosphorylation | AAGSTNGSSDNQSAA CCCCCCCCCCCCCHH | 36.27 | 22817900 | |
| 42 | Phosphorylation | AGSTNGSSDNQSAAS CCCCCCCCCCCCHHC | 41.81 | 21082442 | |
| 78 | Acetylation | ELRDHFGKYGEIESI HHHHHHHCCCEEEEE | 49.49 | 21791702 | |
| 79 | Phosphorylation | LRDHFGKYGEIESIN HHHHHHCCCEEEEEE | 21.99 | 25749252 | |
| 84 | Phosphorylation | GKYGEIESINVKTDP HCCCEEEEEEEEECC | 25.73 | 22668510 | |
| 148 | Phosphorylation | GGLTTEISDEEIKTY CCEECCCCHHHHHHH | 32.51 | 22817900 | |
| 204 | Acetylation | PKQKIAGKEVDVKRA HHHHHCCEECCCCCC | 45.61 | 21791702 | |
| 212 | Phosphorylation | EVDVKRATPKPENQM ECCCCCCCCCCCCCC | 35.56 | 21082442 | |
| 293 (in isoform 2) | Phosphorylation | - | 17.05 | 19429919 | |
| 294 (in isoform 2) | Phosphorylation | - | 14.20 | 19429919 | |
| 299 (in isoform 2) | Phosphorylation | - | 19.32 | 19429919 | |
| 300 (in isoform 2) | Phosphorylation | - | 29.66 | 19429919 | |
| 305 (in isoform 2) | Phosphorylation | - | 24.99 | 19429919 | |
| 306 (in isoform 2) | Phosphorylation | - | 29.24 | 19429919 | |
| 308 (in isoform 2) | Phosphorylation | - | 39.13 | 19429919 | |
| 318 (in isoform 2) | Phosphorylation | - | 52.64 | 19429919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SQD_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SQD_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SQD_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MED19_DROME | MED19 | physical | 14605208 | |
| RB27C_DROME | Hrb27C | physical | 1730753 | |
| RB87F_DROME | Hrb87F | physical | 1730753 | |
| ROA1_DROME | Hrb98DE | physical | 1730753 | |
| RBF_DROME | Rbf | genetic | 19364495 | |
| OTU_DROME | otu | genetic | 15056611 | |
| RB27C_DROME | Hrb27C | genetic | 15056611 | |
| CUP_DROME | cup | physical | 18082158 | |
| RB27C_DROME | Hrb27C | physical | 18082158 | |
| RB27C_DROME | Hrb27C | physical | 15056611 | |
| RB27C_DROME | Hrb27C | physical | 8355684 | |
| GRK_DROME | grk | physical | 10197986 | |
| GRK_DROME | grk | physical | 23213441 | |
| GRK_DROME | grk | physical | 23894566 | |
| PABP_DROME | pAbp | physical | 18082158 | |
| ORB2_DROME | orb2 | physical | 22284910 | |
| ORB2_DROME | orb2 | physical | 26638074 | |
| BCD_DROME | bcd | physical | 23213441 | |
| BCD_DROME | bcd | physical | 23894566 | |
| OSKA_DROME | osk | physical | 23213441 | |
| OSKA_DROME | osk | physical | 23894566 | |
| ROA1_DROME | Hrb98DE | physical | 8355684 | |
| PEP_DROME | Pep | physical | 8355684 | |
| K10_DROME | fs(1)K10 | physical | 10197986 | |
| RB87F_DROME | Hrb87F | physical | 10984439 | |
| RB87F_DROME | Hrb87F | physical | 8355684 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells."; Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.; Mol. Biosyst. 3:275-286(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148, AND MASSSPECTROMETRY. | |
