| UniProt ID | NRBP_DROME | |
|---|---|---|
| UniProt AC | Q9Y0Y6 | |
| Protein Name | Nuclear receptor-binding protein homolog | |
| Gene Name | Madm {ECO:0000312|EMBL:AAF51961.1, ECO:0000312|FlyBase:FBgn0027497} | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 637 | |
| Subcellular Localization | Cytoplasm, cell cortex . | |
| Protein Description | May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus.. | |
| Protein Sequence | MSNSQANAGISGSTVADEPIQHHPSLAAGPVSASCPAATPPSQSTQQPPPHIVSASTADAGSSAAVGVGVVAGSEGVNLDSSPRESGDDSEDESEILEESPCGRWLKRREEVDQRDVPGIDCVHLAMDTEEGVEVVWNEVQYASLQELKSQEEKMRQVFDNLLQLDHQNIVKFHRYWTDTQQAERPRVVFITEYMSSGSLKQFLKRTKRNAKRLPLESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQHNGLVKIGSVVPDAVHYSVRRGRERERERERGAHYFQAPEYGAADQLTAALDIYAFGMCALEMAALEIQPSNSESTAINEETIQRTIFSLENDLQRDLIRKCLNPQPQDRPSANDLLFHPLLFEVHSLKLLTAHCLVFSPANRTMFSETAFDGLMQRYYQPDVVMAQLRLAGGQERQYRLADVSGADKLEKFVEDVKYGVYPLITYSGKKPPNFRSRAASPERADSVKSATPEPVDTESRRIVNMMCSVKIKEDSNDITMTILLRMDDKMNRQLTCQVNENDTAADLTSELVRLGFVHLDDQDKIQVLLEETLKAGVMSDGAGAESSGAGVTTTATMAALEQLERNWSISSDADKQGTAVMYVPQEQQNADGDVDVEHSGTTSN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 86 | Phosphorylation | LDSSPRESGDDSEDE CCCCCCCCCCCCCCH | 49.12 | 29892262 | |
| 90 | Phosphorylation | PRESGDDSEDESEIL CCCCCCCCCCHHHHH | 52.25 | 23607784 | |
| 94 | Phosphorylation | GDDSEDESEILEESP CCCCCCHHHHHHHCC | 42.11 | 29892262 | |
| 473 | Phosphorylation | NFRSRAASPERADSV CHHHCCCCHHHHHCC | 26.72 | 19429919 | |
| 479 | Phosphorylation | ASPERADSVKSATPE CCHHHHHCCHHCCCC | 30.38 | 19429919 | |
| 482 | Phosphorylation | ERADSVKSATPEPVD HHHHCCHHCCCCCCC | 34.91 | 21082442 | |
| 484 | Phosphorylation | ADSVKSATPEPVDTE HHCCHHCCCCCCCCC | 34.96 | 21082442 | |
| 490 | Phosphorylation | ATPEPVDTESRRIVN CCCCCCCCCHHHHHH | 35.77 | 19429919 | |
| 492 | Phosphorylation | PEPVDTESRRIVNMM CCCCCCCHHHHHHHH | 29.02 | 19429919 | |
| 501 | Phosphorylation | RIVNMMCSVKIKEDS HHHHHHEEEEEEECC | 14.46 | 22817900 | |
| 601 | Phosphorylation | EQLERNWSISSDADK HHHHHHCCCCCCCCC | 19.01 | 19429919 | |
| 603 | Phosphorylation | LERNWSISSDADKQG HHHHCCCCCCCCCCC | 19.36 | 19429919 | |
| 604 | Phosphorylation | ERNWSISSDADKQGT HHHCCCCCCCCCCCE | 34.84 | 19429919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NRBP_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NRBP_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NRBP_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of NRBP_DROME !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-473; SER-479; SER-482AND THR-484, AND MASS SPECTROMETRY. | |
