| UniProt ID | DS_DROME | |
|---|---|---|
| UniProt AC | Q24292 | |
| Protein Name | Protein dachsous | |
| Gene Name | ds | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 3503 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein . |
|
| Protein Description | Involved in morphogenesis. May also be involved in cell adhesion.. | |
| Protein Sequence | MLRSSLLILLAIVLLGSSQAASHDQERERKLEVFEGVAVDYQIGYIGDFGGIDSGPPYIIVAEAGVETDLAIDRATGEIRTKVKLDRETRASYSLVAIPLSGRNIRVLVTVKDENDNAPTFPQTSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYLDLQISGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTSVLQVYASDTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGEQPLETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPDSKTEYANVNVTLNGGDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSIFLRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNVSVAENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSSYEFPVLATDRGGLSTTAMIKMQLTDVNDNRPVFYPREYKVSLRESPKASSQASSTPIVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLNISATDGGNLRSNADAVVFLSIIDAMQRPPIFEKARYNYYVKEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKSQVLLNIQATLGEPPVYGHTQVNIEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAHAHDKDSGSSGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPSLSTNLTILVDVQDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNARITYRIVDAGVDNVTNSISSSDVSQHFGIFPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAHAKTRVIVRVLDANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDLDLGENAAIRYSLLPINSSFQVHPVTGEISTREPLDRELRELYDLVVEARDQGTPVRSARVPVRIHVSDVNDNAPEIADPQEDVVSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVKGRDSDGHGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGNPPRETVRMLRVEVLDLNDNRPTFTSSSLVFRVREDAALGHVVGSISPIERPADVVRNSVEESFEDLRVTYTLNPLTKDLIEAAFDIDRHSGNLVVARLLDREVQSEFRLEIRALDTTASNNPQSSAITVKIEVADVNDNAPEWPQDPIDLQVSEATPVGTIIHNFTATDADTGTNGDLQYRLIRYFPQLNESQEQAMSLFRMDSLTGALSLQAPLDFEAVQEYLLIVQALDQSSNVTERLQTSVTVRLRILDANDHAPHFVSPNSSGGKTASLFISDATRIGEVVAHIVAVDEDSGDNGQLTYEITGGNGEGRFRINSQTGIIELVKSLPPATEDVEKGGRFNLIIGAKDHGQPEPKKSSLNLHLIVQGSHNNPPRFLQAVYRATILENVPSGSFVLQVTAKSLHGAENANLSYEIPAGVANDLFHVDWQRGIITTRGQFDRESQASYVLPVYVRDANRQSTLSSSAVRKQRSSDSIGDTSNGQHFDVATIYITVGDVNDNSPEFRPGSCYGLSVPENSEPGVIHTVVASDLDEGPNADLIYSITGGNLGNKFSIDSSSGELSARPLDREQHSRYTLQIQASDRGQPKSRQGHCNITIFVEDQNDNAPRFKLSKYTGSVQEDAPLGTSVVQISAVDADLGVNARLVYSLANETQWQFAIDGQSGLITTVGKLDRELQASYNFMVLATDGGRYEVRSATVPVQINVLDINDNRPIFERYPYIGQVPALIQPGQTLLKVQALDADLGANAEIVYSLNAENSAVSAKFRINPSTGALSASQSLASESGKLLHLEVVARDKGNPPQSSLGLIELLIGEAPQGTPVLRFQNETYRVMLKENSPSGTRLLQVVALRSDGRRQKVQFSFGAGNEDGILSLDSLSGEIRVNKPHLLDYDRFSTPSMSALSRGRALHYEEEIDESSEEDPNNSTRSQRALTSSSFALTNSQPNEIRVVLVARTADAPFLASYAELVIELEDENDNSPKFSQKQFVATVSEGNNKGTFVAQVHAFDSDAGSNARLRYHIVDGNHDNAFVIEPAFSGIVRTNIVLDREIRDIYKLKIIATDEGVPQMTGTATIRVQIVDVNDNQPTFPPNNLVTVSEATELGAVITSISANDVDTYPALTYRLGAESTVDIENMSIFALDRYSGKLVLKRRLDYELQQEYELDVIASDAAHEARTVLTVRVNDENDNAPVFLAQQPPAYFAILPAISEISESLSVDFDLLTVNATDADSEGNNSKVIYIIEPAQEGFSVHPSNGVVSVNMSRLQPAVSSSGDYFVRIIAKDAGKPALKSSTLLRVQANDNGSGRSQFLQNQYRAQISEAAPLGSVVLQLGQDALDQSLAIIAGNEESAFELLQSKAIVLVKPLDRERNDLYKLRLVLSHPHGPPLISSLNSSSGISVIITILDANDNFPIFDRSAKYEAEISELAPLRYSIAQLQAIDADQENTPNSEVVYDITSGNDEHMFTIDLVTGVLFVNNRLDYDSGAKSYELIIRACDSHHQRPLCSLQPFRLELHDENDNEPKFPLTEYVHFLAENEPVGSSVFRAHASDLDKGPFGQLNYSIGPAPSDESSWKMFRVDSESGLVTSAFVFDYEQRQRYDMELLASDMGGKKASVAVRVEIESRDEFTPQFTERTYRFVLPAAVALPQGYVVGQVTATDSDSGPDGRVVYQLSAPHSHFKVNRSSGAVLIKRKLKLDGDGDGNLYMDGRDISLVISASSGRHNSLSSMAVVEIALDPLAHPGTNLASAGGSSSGSIGDWAIGLLVAFLLVLCAAAGIFLFIHMRSRKPRNAVKPHLATDNAGVGNTNSYVDPSAFDTIPIRGSISGGAAGAASGQFAPPKYDEIPPFGAHAGSSGAATTSELSGSEQSGSSGRGSAEDDGEDEEIRMINEGPLHHRNGGAGAGSDDGRISDISVQNTQEYLARLGIVDHDPSGAGGGASSMAGSSHPMHLYHDDDATARSDITNLIYAKLNDVTGAGSEIGSSADDAGTTAGSIGTIGTAITHGHGVMSSYGEVPVPVPVVVGGSNVGGSLSSIVHSEEELTGSYNWDYLLDWGPQYQPLAHVFSEIARLKDDTLSEHSGSGASSSAKSKHSSSHSSAGAGSVVLKPPPSAPPTHIPPPLLTNVAPRAINLPMRLPPHLSLAPAHLPRSPIGHEASGSFSTSSAMSPSFSPSLSPLATRSPSISPLGAGPPTHLPHVSLPRHGHAPQPSQRGNVGTRM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 220 | N-linked_Glycosylation | LRGFMTVNITIQDVN CCCCEEEEEEEEECC | 19.27 | - | |
| 234 | N-linked_Glycosylation | NDNQPIFNQSRYFAT CCCCCCCCCCCEEEE | 39.37 | - | |
| 236 | Phosphorylation | NQPIFNQSRYFATVP CCCCCCCCCEEEECC | 30.01 | 18635802 | |
| 245 | N-linked_Glycosylation | YFATVPENATVGTSV EEEECCCCCCCCCEE | 34.54 | - | |
| 381 | N-linked_Glycosylation | KTEYANVNVTLNGGD CCEEEEEEEEEECCC | 22.36 | - | |
| 416 | N-linked_Glycosylation | LDREIVSNYTLSVVA CCHHHHHCCEEEEEE | 23.94 | - | |
| 564 | N-linked_Glycosylation | IFDQSFYNVSVAENE CCCCCEEEEEEECCC | 19.99 | - | |
| 594 | N-linked_Glycosylation | CGVNAMVNYTIGEGF CCCEEEEEEEECCCC | 18.36 | - | |
| 743 | N-linked_Glycosylation | TQPMHMLNISATDGG CCCEEEEEEECCCCC | 20.70 | - | |
| 966 | N-linked_Glycosylation | GVPSLSTNLTILVDV CCCCCCCCEEEEEEC | 31.63 | - | |
| 991 | N-linked_Glycosylation | EKDEYSVNVSESRSI CCCEEEECCCCCCCC | 26.17 | - | |
| 1006 | N-linked_Glycosylation | NAQIIQVNASDLDTG EEEEEEEEHHHCCCC | 19.83 | - | |
| 1029 | N-linked_Glycosylation | IVDAGVDNVTNSISS EEECCCCCCCCCCCC | 39.86 | - | |
| 1143 | N-linked_Glycosylation | RYSLLPINSSFQVHP EEEEECCCCCEEEEC | 29.66 | - | |
| 1236 | N-linked_Glycosylation | VDRDHGQNASITYSI EECCCCCCEEEEEEE | 40.00 | - | |
| 1453 | N-linked_Glycosylation | PVGTIIHNFTATDAD CCEEEEEEEEECCCC | 26.09 | - | |
| 1479 | N-linked_Glycosylation | IRYFPQLNESQEQAM HHHCCCCCCCHHHHH | 41.44 | - | |
| 1524 | N-linked_Glycosylation | QALDQSSNVTERLQT HHHHCCCCHHHHHHE | 50.40 | - | |
| 1553 | N-linked_Glycosylation | APHFVSPNSSGGKTA CCEEECCCCCCCCEE | 41.10 | - | |
| 1700 | N-linked_Glycosylation | LHGAENANLSYEIPA CCCCCCCCEEEEECC | 40.89 | - | |
| 1884 | N-linked_Glycosylation | KSRQGHCNITIFVED CCCCCCEEEEEEEEC | 28.85 | - | |
| 1940 | N-linked_Glycosylation | RLVYSLANETQWQFA EEEEHHCCCCEEEEE | 59.13 | - | |
| 2115 | N-linked_Glycosylation | TPVLRFQNETYRVML CCEEEECCCEEEEEE | 40.65 | - | |
| 2211 | N-linked_Glycosylation | ESSEEDPNNSTRSQR CCCCCCCCCCHHHHH | 68.36 | - | |
| 2212 | N-linked_Glycosylation | SSEEDPNNSTRSQRA CCCCCCCCCHHHHHH | 50.58 | - | |
| 2421 | N-linked_Glycosylation | ESTVDIENMSIFALD CEEEECCCCEEEEEE | 29.81 | - | |
| 2511 | N-linked_Glycosylation | DFDLLTVNATDADSE CEEEEEEECCCCCCC | 31.71 | - | |
| 2520 | N-linked_Glycosylation | TDADSEGNNSKVIYI CCCCCCCCCCEEEEE | 45.62 | - | |
| 2547 | N-linked_Glycosylation | SNGVVSVNMSRLQPA CCCEEEEEHHHCCCC | 18.40 | - | |
| 2588 | N-linked_Glycosylation | LRVQANDNGSGRSQF EEEEECCCCCHHHHH | 46.46 | - | |
| 2678 | N-linked_Glycosylation | PPLISSLNSSSGISV CCCHHHCCCCCCEEE | 41.62 | - | |
| 2845 | N-linked_Glycosylation | KGPFGQLNYSIGPAP CCCCCCCCEEECCCC | 22.18 | - | |
| 2967 | N-linked_Glycosylation | PHSHFKVNRSSGAVL CCCCCEECCCCCEEE | 38.41 | - | |
| 3195 | Phosphorylation | GSDDGRISDISVQNT CCCCCCCCCEEECCH | 27.77 | 18327897 | |
| 3198 | Phosphorylation | DGRISDISVQNTQEY CCCCCCEEECCHHHH | 23.73 | 18327897 | |
| 3465 | Phosphorylation | LSPLATRSPSISPLG CCCCCCCCCCCCCCC | 20.74 | 18327897 | |
| 3469 | Phosphorylation | ATRSPSISPLGAGPP CCCCCCCCCCCCCCC | 20.57 | 18635802 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DS_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DS_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DS_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MYC_DROME | dm | genetic | 20885789 | |
| DSH_DROME | dsh | genetic | 15175250 | |
| DECA_DROME | dpp | genetic | 15175250 | |
| FAT_DROME | ft | genetic | 20826534 | |
| WNTG_DROME | wg | genetic | 15175250 | |
| FOJO_DROME | fj | genetic | 14757640 | |
| FOJO_DROME | fj | genetic | 15240556 | |
| FOJO_DROME | fj | genetic | 11893338 | |
| NKD_DROME | nkd | genetic | 15175250 | |
| FRIZ_DROME | fz | genetic | 9449678 | |
| MY31D_DROME | Myo31DF | physical | 26073018 | |
| NFS1_DROME | CG12264 | physical | 24114784 | |
| INO1_DROME | Inos | physical | 24114784 | |
| PRIC1_DROME | pk | physical | 24998533 | |
| PRIC1_DROME | pk | physical | 26505959 | |
| ATC1_DROME | Ca-P60A | physical | 24114784 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3465 AND SER-3469, ANDMASS SPECTROMETRY. | |
