BUN2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BUN2_DROME
• UniProt AC: Q24523
• Protein Name: Protein bunched, class 2/F/G isoform
• Gene Name: bun
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1331
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Probable transcription factor required for peripheral nervous system morphogenesis, eye development and oogenesis. May be required for the transmission of the dpp signal and for a morphogenetic movement of the medulla in the brain that reorients the second optic lobe relative to the first. Plays a role in determining proper dorsal cell fates leading to the formation of the dorsal appendages..
• Protein Sequence: MFDRTVNAKFKPASSNAGPGNNPVRRNSMLTPSRGVTIGGTGGNIRKLTKVSSLTSNHHFAVCYPPSNIYQNSNNAGSNSALQRTTSESLRLNMMSRVAAGATPTTVSRASSNSSLATSTSTSLAPKSSSSSGGSNSTPQQQQQQLVSSNNSSSSSNNSFTKASSPNNNGARSVGGAATSAATGTTAAAGSHHHQPHHHHHHHHHHHQHHNHQQQQQQQTSLSQGHASLTVAGGSASAGGGGGGGSGSSSGTAAGGTNRKPKTTSSFEITSVTVGHPKLNAAGDTGDESADDLDESHTDDNSRITDLENETPSMSEDTFSKEEVYYANNALSTNAPVIPTSSQYGLVVVDPIAPSLGQTIQNVQVNVSDNIINVVSGAVTPGGTKKKDDIKETQHRSERFKVVKIESTEPFKRGRWMCMDYLDHSSVGNGGNNNEKTGSSTSEAHAATTDGGAAGVGAGSEAPAHKTTQSMILPPTQKLNENHLEANSTDANWNYAEQQQQQQQQQQQQQTIVGNALTKTLPVALRNVSRSSSVTRSPNATVEFLSPNLLAQQQQQQQQLFDSVNANAASSPNPAGDPNNMDYARTAAMQLHQTLQQLKQREDAMDVPPGAGGYANYQNGGDSAVGAASNNNSAAAATGESQLSTSYVEQQQQQQQPLSPAPLTPQAAPTFAAVAAGQSPNFQLEQQQQQQQATSQIDGIVPQPFNPQQQQQQTPQQSTAQQAAAAANATSAVTAPPPQQTSNTSNAAVTTGQGQTMPLLSHMTSYEQQQPNLGAAAAAAAAGGTAATSVAAPQAIPTLQLQSAPSTIADPQQLMVPQQQQQQQHQEEQQQQPQQQQQPLPPANIASASANNSNLNLTNTNVVATGEATTNALTLTDEQATAALAAAFATGAAAAATGATSAAAATQQQIQQLQQQPNAESETESFITASNPGGNRKRAFSNPHIGGPNDPSFMHRLNPQLYYYNKSQSGRSSFCVDESLWPTNNPNGAVSDTNLYMGSSTDEDYEEAIDQFSPTIYTTRSASRAIPIPNSAGSSPQHQMHHSQPRIAIGINQMEGGGPTRSTGAFSASPSIYAYPHSPFYASSPETSFGSAAMPGHPAASSRISFSYDPAFQRLQVPNASGDRRPRSPLECASVFAAVAAAATCGDAAGGAADTVISSASGTSAVAIDNKIEQAMDLVKSHLMIAVREEVEVLKERISELMDKINKLELENSILKSNIPQETLQQLQLQLQLAAPPATPAIQAAPAVQSVVAPAAAGQAVQQQAAGAVAVTGVATSPASAVVPTSIPNGSAENGSSAVESAAVSVEQQVQQVTSAAAAAASVVTANGPMS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	NAKFKPASSNAGPGN CCCCCCCCCCCCCCC	32.43	21082442
15	Phosphorylation	AKFKPASSNAGPGNN CCCCCCCCCCCCCCC	32.57	21082442
28	Phosphorylation	NNPVRRNSMLTPSRG CCCCCCCCCCCCCCC	17.23	21082442
31	Phosphorylation	VRRNSMLTPSRGVTI CCCCCCCCCCCCEEE	15.58	21082442
37	Phosphorylation	LTPSRGVTIGGTGGN CCCCCCEEECCCCCC	19.41	21082442
52	Phosphorylation	IRKLTKVSSLTSNHH HHHHEEEEECCCCCE	22.61	21082442
55	Phosphorylation	LTKVSSLTSNHHFAV HEEEEECCCCCEEEE	29.45	21082442
78	Phosphorylation	QNSNNAGSNSALQRT CCCCCCCCCCHHHHH	25.79	21082442
106 (in isoform 1)	Phosphorylation	-	20.07	19429919
108	Phosphorylation	GATPTTVSRASSNSS CCCCCCCCCCCCCCC	21.75	21082442
111	Phosphorylation	PTTVSRASSNSSLAT CCCCCCCCCCCCCCE	29.01	21082442
112	Phosphorylation	TTVSRASSNSSLATS CCCCCCCCCCCCCEE	39.48	29892262
114	Phosphorylation	VSRASSNSSLATSTS CCCCCCCCCCCEECC	28.77	21082442
115	Phosphorylation	SRASSNSSLATSTST CCCCCCCCCCEECCC	26.69	21082442
165	Phosphorylation	NSFTKASSPNNNGAR CCCCCCCCCCCCCCC	36.18	30478224
263	Phosphorylation	GTNRKPKTTSSFEIT CCCCCCCCCCCEEEE	40.20	21082442
264	Phosphorylation	TNRKPKTTSSFEITS CCCCCCCCCCEEEEE	28.62	21082442
265	Phosphorylation	NRKPKTTSSFEITSV CCCCCCCCCEEEEEE	37.96	21082442
266	Phosphorylation	RKPKTTSSFEITSVT CCCCCCCCEEEEEEE	25.47	21082442
285	Phosphorylation	KLNAAGDTGDESADD CCCCCCCCCCCCHHH	45.69	25749252
289	Phosphorylation	AGDTGDESADDLDES CCCCCCCCHHHCCCC	41.56	19429919
470	Phosphorylation	PAHKTTQSMILPPTQ CCCCCCCCCCCCCCC	13.00	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BUN2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BUN2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BUN2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STAR_DROME	S	genetic	7555710
POK_DROME	aop	genetic	7555710
HH_DROME	hh	genetic	7555710

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.