AJUBA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AJUBA_DROME
• UniProt AC: Q9VY77
• Protein Name: LIM domain-containing protein jub
• Gene Name: jub
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 728
• Subcellular Localization: Cell junction, adherens junction .
• Protein Description: Regulates organ size by inhibiting apoptosis and promoting cell proliferation by influencing the expression of G1/S-specific cyclin-E (CycE) and apoptosis 1 inhibitor (th). Negatively regulates the Hippo signaling pathway..
• Protein Sequence: MTTQRTQTQARNPGNSDSDYETLMQRLHIGGGGGAGVGGGGGSGGPGDGGVAMRSYQRSPGAIENYLQESQQQQQQHQMQQMQQLHHNQDYKLYERGNIIAASKYATPRPVEQIQHTHNGSAQIYAPTAQILGQRIAPQKHSPVYENLEFYGQFDSNHKRAQPQSPGSRQSAILNGYLLMQPIRAGRFAHTPVPENQGSASLGTTRAAGGPPPPSGRSAALGPTGDLEEHAAPIYENIIPHSGQRAQPQASPATATMYQEMQPTSNSSGSSSTAGLDLNALLASPMHQRSISSNTASSSSLGSPTQRYRNLSLPSHLSPVPTAQSVAKLQQHTPVKSPGGAINVSVNPNYIEDINSSDYVCMTANLHRNTAAGLATGRAAATGAPAQRTVQEPPIITSSLAMGMATAAPPTTSNAPTSAAAAPAAPTSTASLRATPIAMTAPLAVATSPTPSQGSTAVNAALKPRRGLTKNLLPYSVTPPRPAGPTEAQRKIEELTRQLEEEIEQSEEHGEYFGICHTCGEKVKGAGQACQAMGNLYHTNCFICCSCGRALRGKAFYNVHGRVYCEEDYMYSGFQQTAEKCAICGHLIMEMILQAMGKSYHPGCFRCCVCNECLDGVPFTVDVDHKIYCVNDYHRMFAPKCASCGKGITPVEGTDETVRVVSMDKDFHVDCYICEECGMQLTDEPDKRCYPLDGRLLCRGCHLQRLALQSSPHARHQEPVCASYQYMG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	PGNSDSDYETLMQRL CCCCCHHHHHHHHHC	18.11	18281928
59	Phosphorylation	AMRSYQRSPGAIENY CCCCCCCCCHHHHHH	16.50	30478224
165	Phosphorylation	HKRAQPQSPGSRQSA CCCCCCCCCCCHHHH	37.60	19429919
168	Phosphorylation	AQPQSPGSRQSAILN CCCCCCCCHHHHHHC	30.45	19429919
171	Phosphorylation	QSPGSRQSAILNGYL CCCCCHHHHHHCCEE	19.03	21082442
290	Phosphorylation	ASPMHQRSISSNTAS HCHHHHCCCCCCCCC	21.91	21082442
292	Phosphorylation	PMHQRSISSNTASSS HHHHCCCCCCCCCCC	20.84	21082442
303	Phosphorylation	ASSSSLGSPTQRYRN CCCCCCCCCCHHHCC	30.02	27626673
312	Phosphorylation	TQRYRNLSLPSHLSP CHHHCCCCCCCCCCC	41.61	19429919
315	Phosphorylation	YRNLSLPSHLSPVPT HCCCCCCCCCCCCCC	42.21	19429919
318	Phosphorylation	LSLPSHLSPVPTAQS CCCCCCCCCCCCHHH	20.59	19429919
370	Phosphorylation	TANLHRNTAAGLATG ECCCCCCCHHHHHHC	20.17	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AJUBA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AJUBA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AJUBA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAV_DROME	sav	physical	23484853
CTNA_DROME	alpha-Cat	physical	24995985
WARTS_DROME	wts	physical	23484853
WARTS_DROME	wts	physical	24995985

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.