MNB_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MNB_DROME
• UniProt AC: P49657
• Protein Name: Serine/threonine-protein kinase minibrain
• Gene Name: mnb
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 908
• Subcellular Localization: Nucleus .
• Protein Description: Role in the specific control of proper proliferation of optic lobe neuronal progeny..
• Protein Sequence: MYRLEDTNSGGVMDKNKQKLSAYGSSGGSVDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSSGAVSSSSAAAPTAATAAATAAGSSGSGSSVGGGSSAAQQQQAMPLPLPLPLPLPPLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLANSHHSTNSLGSLNHISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDPPQMPPPPPNGHGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDSSVISASAAGGGQGGGNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQLPPSSSSSVSSGSASVGSGGVGVGVVGQRRHITGPAAQVGISQSVGSGSSGSATGASSSDASSSSPMVGVCVQQNPVVIH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	RDVMHHHSSPSSSSE HHHCCCCCCCCCHHH	39.32	19429919
71	Phosphorylation	DVMHHHSSPSSSSEV HHCCCCCCCCCHHHH	25.17	19429919
73	Phosphorylation	MHHHSSPSSSSEVRA CCCCCCCCCHHHHHH	44.81	19429919
74	Phosphorylation	HHHSSPSSSSEVRAM CCCCCCCCHHHHHHH	41.07	19429919
75	Phosphorylation	HHSSPSSSSEVRAMQ CCCCCCCHHHHHHHH	34.55	19429919
76	Phosphorylation	HSSPSSSSEVRAMQA CCCCCCHHHHHHHHH	41.90	19429919
326	Phosphorylation	LGQRIYHYIQSRFYR HHHHHHHHHHHHCCC	5.45	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MNB_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MNB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MNB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIR2_DROME	Sir2	genetic	22876196
FOXO_DROME	foxo	genetic	22876196
MNB_DROME	mnb	physical	23955303
WARTS_DROME	wts	physical	23955303

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.