RTF1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RTF1_DROME
• UniProt AC: Q9W261
• Protein Name: RNA polymerase-associated protein Rtf1
• Gene Name: Rtf1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 775
• Subcellular Localization: Nucleus, nucleoplasm . Chromosome . Co-localizes with Paf1 and RNA polymerase II on transcriptionally active sites on chromosomes.
• Protein Description: Plays a role in transcription-coupled histone modification. Required for methylation of 'Lys-4' of histone H3. Plays a role in regulation of transcription. Required for maximal induction of heat-shock genes. Plays a role in Notch signaling in the wing margins..
• Protein Sequence: MGKRRTQSLIDSNSSDSDSESETNLESDLMSLAKKRKKPQTAAKSSSRSDSDSDWANNKAGAPSSKKKKRQKPSRDSSSSESNWDDDSQDERQPARQSPAQTQQEHKPPEQASQPAQLSEQEEGEVSDSDSDKSKSNSSSSGSDSSSSSSSSDSEFDDGFDDDLMGDDEDRRRLNGLSEKERETEIYKRIEQREIMRTRWEIERKLKLARRGEKNQEKSKNKGERAKKKKEKREKKARKAREAQAPLPTQASTSTLLDVEPKPSNEVRSASPLSTPALNRDAASTSAAVASIMPDDAASSAGVSDYFDHKERSKERKKNVEANKTDDKRSNAMALLKAKREGKAKREEEEAKRMAEKDRDDDKEELDSVSGCKSAVKLKASEIYSDDSGSSDWDEEEKPAGKRSRSNSSKASSESEDEEKAPQRPVFITTREDLNKLRLSRYKMERFVNLPIFESTVLNCFVRISIGNNGQKPVYRVAEIVGVVETGKIYSLGTTRTNRGLRLKHGTQERVFRLEFISNQEFTENEFNKWNEVCQQSHVQMPTIDLIAIKQNDIKKALNYEFKDEDVDKIVEEKNRFRNRPTNYAMKKTCLMKERDAAMLRGDYDIAQDLGQQIDELENRASELDKRRSHTLNLISYINDRNRKKNVEDAEKAILEEARANKGLKISDPFTRRITQPRMGFKGAKKDEDDMQLAPLPPPPPGKKRPNEAGTSSASVRSTDSKDYSLYSLHDFDIDLDVPLPVNTNSVPKPASKPAETVSKRSLNLEDYKKKRGLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	KPQTAAKSSSRSDSD CCCCHHHCCCCCCCC	28.90	19429919
46	Phosphorylation	PQTAAKSSSRSDSDS CCCHHHCCCCCCCCC	29.12	19429919
47	Phosphorylation	QTAAKSSSRSDSDSD CCHHHCCCCCCCCCH	42.78	19429919
49	Phosphorylation	AAKSSSRSDSDSDWA HHHCCCCCCCCCHHH	43.33	19429919
51	Phosphorylation	KSSSRSDSDSDWANN HCCCCCCCCCHHHCC	40.02	19429919
53	Phosphorylation	SSRSDSDSDWANNKA CCCCCCCCHHHCCCC	38.72	19429919
74	Phosphorylation	KKKRQKPSRDSSSSE HHHCCCCCCCCCCCC	56.61	19429919
77	Phosphorylation	RQKPSRDSSSSESNW CCCCCCCCCCCCCCC	30.89	19429919
78	Phosphorylation	QKPSRDSSSSESNWD CCCCCCCCCCCCCCC	42.02	19429919
79	Phosphorylation	KPSRDSSSSESNWDD CCCCCCCCCCCCCCC	41.92	19429919
80	Phosphorylation	PSRDSSSSESNWDDD CCCCCCCCCCCCCCC	47.17	19429919
82	Phosphorylation	RDSSSSESNWDDDSQ CCCCCCCCCCCCCCC	45.21	19429919
88	Phosphorylation	ESNWDDDSQDERQPA CCCCCCCCCCCCCHH	46.67	19429919
180	Acetylation	RLNGLSEKERETEIY HHCCCCHHHHHHHHH	59.71	21791702
269	Phosphorylation	KPSNEVRSASPLSTP CCCCCCCCCCCCCCC	37.97	19429919
271	Phosphorylation	SNEVRSASPLSTPAL CCCCCCCCCCCCCCC	27.85	19429919
274	Phosphorylation	VRSASPLSTPALNRD CCCCCCCCCCCCCCC	35.41	19429919
275	Phosphorylation	RSASPLSTPALNRDA CCCCCCCCCCCCCCH	21.92	19429919
368	Phosphorylation	DDKEELDSVSGCKSA CCHHHHHHHCCCHHH	30.70	19429919
370	Phosphorylation	KEELDSVSGCKSAVK HHHHHHHCCCHHHHH	42.28	19429919
384	Phosphorylation	KLKASEIYSDDSGSS HHHHHHHCCCCCCCC	11.29	22817900
385	Phosphorylation	LKASEIYSDDSGSSD HHHHHHCCCCCCCCC	40.37	19429919
388	Phosphorylation	SEIYSDDSGSSDWDE HHHCCCCCCCCCCCC	45.63	19429919
390	Phosphorylation	IYSDDSGSSDWDEEE HCCCCCCCCCCCCCC	29.13	19429919
391	Phosphorylation	YSDDSGSSDWDEEEK CCCCCCCCCCCCCCC	46.36	19429919
412	Phosphorylation	RSNSSKASSESEDEE CCCCCCCCCCCCCHH	38.07	22817900
413	Phosphorylation	SNSSKASSESEDEEK CCCCCCCCCCCCHHH	50.42	22817900
415	Phosphorylation	SSKASSESEDEEKAP CCCCCCCCCCHHHCC	52.90	22817900
629	Phosphorylation	SELDKRRSHTLNLIS HHHHHHHHHHHHHHH	25.51	19429919
631	Phosphorylation	LDKRRSHTLNLISYI HHHHHHHHHHHHHHH	20.70	19429919
762	Phosphorylation	AETVSKRSLNLEDYK CCCCCCCCCCHHHHH	25.91	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RTF1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RTF1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RTF1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RUXE_DROME	SmE	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-51; SER-53;SER-269; SER-271; TYR-384; SER-385; SER-388; SER-390; SER-391;SER-412; SER-413 AND SER-415, AND MASS SPECTROMETRY.
PubMed: 18327897