SIF1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIF1_DROME
• UniProt AC: P91621
• Protein Name: Protein still life, isoform SIF type 1
• Gene Name: sif
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 2072
• Subcellular Localization: Cell junction, synapse . Localizes to the submembranous region of synaptic terminals.
• Protein Description: Regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating Rho-like GTPases. Is likely a factor in the cascade of Rac1 or Cdc42 in the neurons..
• Protein Sequence: MGNKLSCSCAPLMRKAYRYEDSPWQSSRRRDGHLLSSFRLWAEVFHVSASGAGTVKWQQVSEDLVPVNITCIQDSPECIFHITAYNSQVDKILDVRLVQPGTRIGQASECFVYWKDPMTNDTWGLNFTSPIDAKQFRECCSPSFKFSRKASSSYSLKLDPPGKGKVKAKRKPLSTPASPSRVRQEPQCTCMSAEQYARLRTDPRVRGSSTLPRNVGSHRITDVDGQQQVGSGKVVSAVSSTSLYDNVASGGPGTNQGADTLPRQMKGGQQDRQDVANSGVNTNTPGVIVTGVGNVGSDMCGQNHVGSQVGNDDPAACQMDMDLSKSEGTQAGGGLHQSVGTCTSSSKGTGTRNKDFGDDMTRDAHSHDMHQHNVINNNTRRKTKSTEDMNVDTSTLKRMLKPMPSTESPVTSPEMGRRRYNYYNANAAQTLGHPPHMHQHGMAMGMGGGGGGGHHIMNNNTMGRASSQSSRFSGSRSSHEIGRGYPPRNLYLELERERSCIEGSPPSDNVMFDNQCYATTPSSSNGNSDQDQSYGQQQSSGQHPQQQQGPPQRSSRHQHHHQQAPNVTPTPGSPTSRLLLEYEMHLRNTLAKGMDAESYSLHTFEALLSQSMENLANAKSSTLPLPPHRPLSTIRDKERDRDRDGYYSDRNELIRERERERDRGYLSDHNSSFSNSRCASCIGESARAQWFRHSDGWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLPSLRQDSSLNDSGYKSARADSLEQRAEFIRQDSLRSEYLSDRESRYGIVQQASIESTDSRMCYLTSSEISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHLLQEEIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVRVKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGSPVWKPRDMINLGTDPQSTTRKDDVKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGNKLSCSC ------CCCCCCCCH	51.81	-
151	Phosphorylation	FKFSRKASSSYSLKL CCCCCCCCCCCEEEC	23.89	27794539
152	Phosphorylation	KFSRKASSSYSLKLD CCCCCCCCCCEEECC	37.85	27794539
155	Phosphorylation	RKASSSYSLKLDPPG CCCCCCCEEECCCCC	22.45	27794539
385	Phosphorylation	NTRRKTKSTEDMNVD CCCCCCCCCCCCCCC	42.11	27794539
600	Phosphorylation	GMDAESYSLHTFEAL CCCCHHHHHHHHHHH	23.97	27794539
611	Phosphorylation	FEALLSQSMENLANA HHHHHHHHHHHHHCC	25.37	27794539
823	Phosphorylation	DGESVMASPYKAKAT CCCCCCCCCCEEEEC	15.63	27794539
1410	Phosphorylation	AEQETRKSSPTGSVT HHHHHHHCCCCCCCC	37.95	27794539
1411	Phosphorylation	EQETRKSSPTGSVTS HHHHHHCCCCCCCCC	29.53	27794539
1415	Phosphorylation	RKSSPTGSVTSSVST HHCCCCCCCCCCCCC	25.38	27794539
1809	Phosphorylation	PMKNFGGSSGSVSGH CCCCCCCCCCCCCCC	31.72	27794539
1810	Phosphorylation	MKNFGGSSGSVSGHS CCCCCCCCCCCCCCC	38.06	27794539
1812	Phosphorylation	NFGGSSGSVSGHSSQ CCCCCCCCCCCCCCC	18.30	27794539
1983	Phosphorylation	RIDPGTKSEGEEDSQ CCCCCCCCCCCCCCC	51.15	27794539
1989	Phosphorylation	KSEGEEDSQQGTIRP CCCCCCCCCCCCCCC	27.90	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIF1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIF1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIF1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FAS2_DROME	Fas2	genetic	10976048

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.