YL_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YL_DROME
• UniProt AC: P98163
• Protein Name: Putative vitellogenin receptor
• Gene Name: yl
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1984
• Subcellular Localization: Cell membrane ; Single-pass membrane protein .
• Protein Description: Involved in uptake of vitellogenin by endocytosis..
• Protein Sequence: MCQAEHQVHPSEQRIRVESPKMTASRRGFNLTSQTRAHPSSGGSTSSRYGNCQRTHLIINGRHVAISLLLLVGLCGGTAAGTPGSADTRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDELDCDYRLCRPPHWFPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRMRSCSKYEFMCQQDRTCIPIDFMCDGRPDCTDKSDEVAGCKQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERGCLNLCEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKPDCDAKKCALGAKCHMMPASGAECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQVAGNLSKVIGVAYDGSHIYWTNIQNEAESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRTIYAVHIYHPAKQPNSPHGCENATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTAFGRHQVSKSYTLPCLINEMVYNRINGSLIIADNDQRLILEFQPESHESNVLVRSNLGNVSALAFDHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLYVVLKAKRHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYRVPHSQIFRGKLRRPYSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASSPVGQESHPCQQQNGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTCVEALDCEFRCHSGECLTMNHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDEQHCEKFDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEATSRCEPGMFQCGSGSCIAGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQRCLLGQCLDRSLVCDGHNDCGDKSDELNCGTDSSTMNISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDEADCGDVCSIYEFKCRSGRECIRREFRCDGQKDCGDGSDELSCELEKGHHNQSQIQPWSTSSRSCRPHLFDCQDGECVDLSRVCNNFPDCTNGHDEGPKCATACRSASGRQVCQHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQPCAQLCENTLGGYQCQCHADFMLRQDRVSCKSLQSGATLLFSSFNEVRNLSEQPVMLNVAWSANDSRITGFDLAMHRQMGYFSAEDEGIVYQIDLQTKVIVRALGLPAPTKLSVDWVTGNVYVLSGAQEIQACSFVGRMCGRIVHVKSPRHVKHLAVDGYHARIFYIVIRTEGYGQTSSEIHMARLDGSRRDMLLQRSESFMTALTTDPHQQLLYFVDQHMRTLERISYRLKTGPMRRPEIMLQKSNALMHPSGLSVYENNAFIVNLGSVEAVQCALYGSRICHKISINVLNAQDIVVAGRSRQPQKASHPCAHAHCHGLCLQADYGYECMCGNRLVAEGERCPHGSGNEVAVLGAVNSLELEHEHEQNGHFHWLMALFVLAAGSLIAGLGYMYYQYRQRGHTDLNINMHFQNPLATLGGTKAFLEHERAEAGVGFTTETGTVSSRGSNDTFTTTSATSSFAAQQFSVPNALQRLLRPRQSASGDPMAQELLLESPSRESKLHALDGGGAGGDGDGGRGVGRQVPDILVADMDDDAAKSAGQFGGNYAGNDANARFVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	N-linked_Glycosylation	TASRRGFNLTSQTRA CCCCCCCCCCCCCCC	45.28	-
365	N-linked_Glycosylation	LCSQGCENTSGGYRC HHHCCCCCCCCCEEE	43.55	-
384	N-linked_Glycosylation	GYLLDKDNRTCRAVV CEEEECCCCEEEEEE	47.07	-
429	N-linked_Glycosylation	HVYQVAGNLSKVIGV HHHHHHCCHHHEEEE	31.25	-
666	N-linked_Glycosylation	NSPHGCENATCSHLC CCCCCCCCCCCCCEE	44.63	-
749	N-linked_Glycosylation	EMVYNRINGSLIIAD HHHHHCCCCEEEEEC	30.66	-
782	N-linked_Glycosylation	LVRSNLGNVSALAFD EEECCCCCHHHHHHH	27.95	-
1022	N-linked_Glycosylation	FVYRDAGNRTCVEAL EEEEECCCCCEEEEE	37.50	-
1075	Phosphorylation	RKPKVLCSPNQFACH CCCCEEECCCCCCCC	23.79	22668510
1240	N-linked_Glycosylation	GTDSSTMNISCAEDQ CCCCCCCCCCCCCCE	24.10	-
1265	N-linked_Glycosylation	LPSTVRCNGTTECPR CCCCEEECCCCCCCC	40.04	-
1326	N-linked_Glycosylation	ELEKGHHNQSQIQPW EECCCCCCCHHCCCC	37.21	-
1475	N-linked_Glycosylation	SSFNEVRNLSEQPVM CCHHHHCCCCCCCEE	53.76	-
1490	N-linked_Glycosylation	LNVAWSANDSRITGF EEEEECCCCCCCCCE	42.13	-
1907	Phosphorylation	RLLRPRQSASGDPMA HHHCCCCCCCCCHHH	26.19	30478224
1921	Phosphorylation	AQELLLESPSRESKL HHHHHHHCCCCCCCE	28.30	30478224
1926	Phosphorylation	LESPSRESKLHALDG HHCCCCCCCEECCCC	39.13	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YL_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YL_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YL_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MNB_DROME	mnb	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1926, AND MASSSPECTROMETRY.
PubMed: 18327897