KP58_DROME - dbPTM
KP58_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KP58_DROME
UniProt AC Q9VPC0
Protein Name Serine/threonine-protein kinase PITSLRE
Gene Name Pitslre
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 952
Subcellular Localization Nucleus .
Protein Description Acts as a negative regulator of the normal cell cycle progression. May function in regulating proliferation by the phosphorylation and subsequent plasma membrane targeting of galactosyltransferase (By similarity)..
Protein Sequence MVNSSGSEDGQLRSPNDVHYHSRGEEDEHEGDADALYIQPPQASRESGSGPRREKKKHSRERRRHKERDDVGGAALALERDHRYDYRSREEHYHHHQRERSSNAAAAYAKHHLGHAYHYPQPPQQQQQPLPPAPSYAAHHYHHHQHLSGARAAPREYHSYPSGYHSGSRHGDYPMEEPTRRSSKYAESKDAESLEQDLRSRLLKKRHNYVKDYETEENYEHRVERSDRREGGRKERERTVRSTHKQNRHDRVIELLDSPEQEHHHQHQHKSHRSKWREEVEVIRRKVPEDLELLARREKLLAAERESRQRKQTAREELEARRELLRERNEHSDALSPTTVAASVTAGLNIHVKRKSKPDNYEKEIKLKKRREDDIEVIRDDDDEESEESDSNEEVPEQDSEGSATESGSEDSYASKKKSKIKSKSQLEDDDEDLPLPDSPLSVGELYKSPKQRQRSRSVSSKSSSQSSRSSRSRSRSRSQSSLEDEVDRQDVGADASPSSSTRSEERGMTQEQPEEKPEEKLKEKQKSLEEQIPCDDKGIPLPNYYPGVQGCRSVEEFQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGFPITSLREINTLLKGQHPNIVTVREIVVGSNMDKIFIVMDYVEHDLKSLMETMKNRKQSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAEFLQMLPLFPGKSEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQLRKHFQEKTSEMGLSLLQGLLTYDPKQRLSADAALKHGFFKELPLPIDPSMFPTWPAKSELGARKAQASSPKPPSGGSQFKQLGRDEPIIVGPGNKLSSGIITGNKKSHGAGGSSASTGFVLNAGITQRQLAMGPGFSLKF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MVNSSGSEDGQ
----CCCCCCCCCCC		25.3529892262
5Phosphorylation---MVNSSGSEDGQL
---CCCCCCCCCCCC		40.9329892262
7Phosphorylation-MVNSSGSEDGQLRS
-CCCCCCCCCCCCCC		34.1729892262
14PhosphorylationSEDGQLRSPNDVHYH
CCCCCCCCCCCCCCC		36.3319429919
20PhosphorylationRSPNDVHYHSRGEED
CCCCCCCCCCCCCCC		11.0119429919
22PhosphorylationPNDVHYHSRGEEDEH
CCCCCCCCCCCCCCC		34.5119429919
258PhosphorylationRVIELLDSPEQEHHH
HHHHHHCCCCHHCCH		30.2423607784
336PhosphorylationNEHSDALSPTTVAAS
HHCCCCCCHHHHHHH		23.1719429919
338PhosphorylationHSDALSPTTVAASVT
CCCCCCHHHHHHHHH		30.4419429919
339PhosphorylationSDALSPTTVAASVTA
CCCCCHHHHHHHHHH		16.1319429919
363AcetylationSKPDNYEKEIKLKKR
CCCCCHHHHHCCCCC		55.1421791702
425PhosphorylationKSKIKSKSQLEDDDE
HHHCCCHHHCCCCCC		47.2722817900
439PhosphorylationEDLPLPDSPLSVGEL
CCCCCCCCCCCHHHH		26.2919429919
442PhosphorylationPLPDSPLSVGELYKS
CCCCCCCCHHHHHCC		31.3119429919
447PhosphorylationPLSVGELYKSPKQRQ
CCCHHHHHCCHHHHH		12.7219429919
449PhosphorylationSVGELYKSPKQRQRS
CHHHHHCCHHHHHHH		24.6319429919
477PhosphorylationSSRSRSRSRSQSSLE
HHHHHHHHHCHHHHH		37.2119429919
479PhosphorylationRSRSRSRSQSSLEDE
HHHHHHHCHHHHHHH		35.3419429919
481PhosphorylationRSRSRSQSSLEDEVD
HHHHHCHHHHHHHCH		37.8319429919
482PhosphorylationSRSRSQSSLEDEVDR
HHHHCHHHHHHHCHH		28.3019429919
712PhosphorylationGLAREYGSPIKKYTS
HHHHHHCCCCHHHHH		23.6627794539
880PhosphorylationGARKAQASSPKPPSG
CCCCCCCCCCCCCCC		34.7819429919
881PhosphorylationARKAQASSPKPPSGG
CCCCCCCCCCCCCCC		39.7021082442
886PhosphorylationASSPKPPSGGSQFKQ
CCCCCCCCCCHHHHH		65.4021082442
889PhosphorylationPKPPSGGSQFKQLGR
CCCCCCCHHHHHCCC		35.6519429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KP58_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KP58_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KP58_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of KP58_DROME !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KP58_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439; SER-442; TYR-447;SER-449; SER-881 AND SER-886, AND MASS SPECTROMETRY.

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