C3G_DROME - dbPTM
C3G_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID C3G_DROME
UniProt AC O77086
Protein Name Guanine nucleotide-releasing factor 2
Gene Name C3G
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1571
Subcellular Localization
Protein Description Guanine nucleotide-releasing protein that binds to SH3 domain of Crk. Transduces signals from Crk to activate RAS. Also involved in MAPK activation..
Protein Sequence MPQFDESFLSDCALADRWHFYSYTVKQLPPHPSPKPNRNRNPYPSGASHDDHQHQLHHHHHQQHHHNHHRLWKTQRQSWSPRDTNNNHSLTSNNCNCNSSNTCNSISATGNTLHSIKFHRRRKYKKLARLALSTPAIPLQMDVDVDVNVTVDREFDMEMDTPVPLKNAVCHGSISSPSTPGTCSSGIGVGGGGCSSSSNNSINSGSYSTACTPPPPTHQHHSQHQQLQGTPGGSSRVGGAGAGGGGGVPPAPPSAGSSGHKNSLKGTKLARRARSFKDDLIEKISLMRTTNNTLGRSHSPHSPRTKHGTKAPPTTEEVLRSTQTLETHVKDISNALKHFRDVILKKKLEVLPGNGTVILETIASMYSVIQTYTLNENSAIMSSATLQVYQSLGKLIKLCDEVMLSEDSGECASLSNENVREVIDLLEDAVRNLVTLAQGKLKEQDQCAFRYSGSGLGGIGAAAEIMGAVTASPGASVPGTGVMRVSAAESAAQRTSLPDIALTPKERDILEQHNVNPMRGSHSTESILRDTSPPPKPPLPNRASNPPPLPPKRRSQPSASAGTVGVGCSSSTSTSNQASPLPYAQSHNISLNSDLDCSSNISLLNYGVDRLSVRSRSPDENSQCSFDSALNHSREEEDQQQQHQHLRSFPKLAAMMDEDMDKMVSYSAAIDDKTQTPLSTGGGIAGVAGGTGGAGEGVAAAASGDGETNSNRHSNESGFVSMREFRTSTQTTDYSVQSSTKSSSSNSEIAFSISESTAVGSSSEYQQISQLVSHSQRHISSSSSSCTTTTTSSSTTTGYGSSEVEQLQQQQQQQTTTTPADLAPALPPKSIQRSSLTRHDSPGVGDELDEVQSSSGWASHRSSQSEVAELRQLSPLHHLNHHPHTASAGQLQQWHSKHHSLIEGPRLQLAGSGSCSAFDQRHLDQEPPPLPIKKKHILAYMEICSASTRSIEQHRHTMHACNISRNISHSQTMNIMPMSKELSPELEMPPALPPKNYKQRKATSMVASPTLQPVIVTTPPPSPKPTLGENGSTGRPDSRMATVCEELNDAVASEDAMPEPRSPVLDSNENVSAVDDGQTFYCHSHQLPAAEMEMSEDASSADNQPITTPQVLEEQEEPTAESRPLVAVHESVKPANVDEDEEAERADMLINMLEEVNITRYLILKKREEDGPEVKGGYIDALIVHASRVQKVADNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAAKETFALLVRVVNDLTSTDLTSQLLSLLVEFVYQLVCSGQLYLAKLLRNKFVEKVTLYKEPKVYGFVGELGGAGSVGGAGIAGSGGCSGTAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLEWQKGITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRFFDNFKDFMGEEEMWQISEKIKPRGRRPVNY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
275PhosphorylationKLARRARSFKDDLIE
HHHHHHHHCCHHHHH		35.3519429919
297PhosphorylationTNNTLGRSHSPHSPR
CCCCCCCCCCCCCCC		26.9027626673
299PhosphorylationNTLGRSHSPHSPRTK
CCCCCCCCCCCCCCC		26.0919429919
302PhosphorylationGRSHSPHSPRTKHGT
CCCCCCCCCCCCCCC		21.3319429919
495PhosphorylationAESAAQRTSLPDIAL
HHHHHHHCCCCCCCC		23.6419429919
496PhosphorylationESAAQRTSLPDIALT
HHHHHHCCCCCCCCC		39.8419429919
521PhosphorylationNVNPMRGSHSTESIL
CCCCCCCCCCHHHHH		12.1422668510
523PhosphorylationNPMRGSHSTESILRD
CCCCCCCCHHHHHCC		35.2519429919
524PhosphorylationPMRGSHSTESILRDT
CCCCCCCHHHHHCCC		28.4719429919
526PhosphorylationRGSHSTESILRDTSP
CCCCCHHHHHCCCCC		27.3219429919
531PhosphorylationTESILRDTSPPPKPP
HHHHHCCCCCCCCCC		36.3819429919
532PhosphorylationESILRDTSPPPKPPL
HHHHCCCCCCCCCCC		39.4319429919
615PhosphorylationVDRLSVRSRSPDENS
CCEEEECCCCCCCCC		34.6519429919
617PhosphorylationRLSVRSRSPDENSQC
EEEECCCCCCCCCCC		37.6419429919
622PhosphorylationSRSPDENSQCSFDSA
CCCCCCCCCCCHHHH		30.4323607784
862PhosphorylationSGWASHRSSQSEVAE
CCCCCCCCCHHHHHH		27.5719429919
863PhosphorylationGWASHRSSQSEVAEL
CCCCCCCCHHHHHHH		37.3719429919
900PhosphorylationQWHSKHHSLIEGPRL
HHHHHCCCCCCCCCE		30.6621082442
914PhosphorylationLQLAGSGSCSAFDQR
EEECCCCCCCCCCCC		13.4421082442
916PhosphorylationLAGSGSCSAFDQRHL
ECCCCCCCCCCCCCC		33.4021082442
968PhosphorylationCNISRNISHSQTMNI
HHCCCCCCCCCCCCC		22.1921082442
970PhosphorylationISRNISHSQTMNIMP
CCCCCCCCCCCCCCC		22.1321082442
983PhosphorylationMPMSKELSPELEMPP
CCCCCCCCCCCCCCC		19.8819429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of C3G_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of C3G_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of C3G_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAS3_DROMERgenetic
9878058
RAS1_DROMERas85Dgenetic
9878058
ERKA_DROMErlgenetic
9878058
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of C3G_DROME

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496; SER-523; THR-524;SER-526 AND SER-615, AND MASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory