MICAL_DROME - dbPTM
MICAL_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MICAL_DROME
UniProt AC Q86BA1
Protein Name [F-actin]-monooxygenase Mical
Gene Name Mical
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 4723
Subcellular Localization Cytoplasm.
Protein Description Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits at 'Met-44' and 'Met-47' through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament disassembly and prevent repolymerization. Plays a key role in semaphorin-plexin repulsive axon guidance and cell morphological changes, probably via its ability to modify and regulate actin..
Protein Sequence MSRQHQRHHQQHHHLPPHQQPQQQMPQQQQQLTAQQQQQQQLLMAEHAAAAEAAELFDLLCVATTMRQILALHRAMCEAVGLRPSPLNDFYPRLKAKVRSWKAQALWKKFDARAAHRVYGKGAACTGTRVLVIGAGPCGLRTAIEAQLLGAKVVVLEKRDRITRNNVLHLWPFVITDLRNLGAKKFYGKFCAGSIDHISIRQLQCMLLKVALLLGVEIHEGVSFDHAVEPSGDGGGWRAAVTPADHPVSHYEFDVLIGADGKRNMLDFRRKEFRGKLAIAITANFINKKTEAEAKVEEISGVAFIFNQAFFKELYGKTGIDLENIVYYKDETHYFVMTAKKHSLIDKGVIIEDMADPGELLAPANVDTQKLHDYAREAAEFSTQYQMPNLEFAVNHYGKPDVAMFDFTSMFAAEMSCRVIVRKGARLMQCLVGDSLLEPFWPTGSGCARGFLSSMDAAYAIKLWSNPQNSTLGVLAQRESIYRLLNQTTPDTLQRDISAYTVDPATRYPNLNRESVNSWQVKHLVDTDDPSILEQTFMDTHALQTPHLDTPGRRKRRSGDLLPQGATLLRWISAQLHSYQFIPELKEASDVFRNGRVLCALINRYRPDLIDYAATKDMSPVECNELSFAVLERELHIDRVMSAKQSLDLTELESRIWLNYLDQICDLFRGEIPHIKHPKMDFSDLRQKYRINHTHAQPDFSKLLATKPKAKSPMQDAVDIPTTVQRRSVLEEERAKRQRRHEQLLNIGGGAAGAAAGVAGSGTGTTTQGQNDTPRRSKKRRQVDKTANIEERQQRLQEIEENRQERMSKRRQQRYHQTQNFYKSLQLLQAGKLLREGGEAGVAEDGTPFEDYSIFLYRQQAPVFNDRVKDLERKLLFPDRERGDIPSALPRTADEQFSDRIKNMEQRMTGRGGLGGDKKPKDLMRAIGKIDSNDWNVREIEKKIELSKKTEIHGPKGREKVPKWSKEQFQARQHKMSKPQRQDSREAEKFKDIDQTIRNLDKQLKEGHNLDVGERGRNKVASIAGQFGKKDEANSDEKNAGSSNATTNTNNTVIPKSSSKVALAFKKQAASEKCRFCKQTVYLMEKTTVEGLVLHRNCLKCHHCHTNLRLGGYAFDRDDPQGRFYCTQHFRLPPKPLPQRTNKARKSAAAQPASPAVPPTAGSVPTAAATSEHMDTTPPRDQVDLLETSRANASADAMSDDEANVIDEHEWSGRNFLPESNNDSQSELSSSDESDTESDSEMFEEADDSPFGAQTLQLASDWIGKQYCEDSDDSDDFYDSSEGIADDGKDDTEGEEFKKARELRRQEVRLQPLPANLPTDTETEKLKLNVDNKENMADRSSLKSGNSFESARSQPSTPLSTPTRVEMEQLERNAPRKFSSEIEAISEKLYHMNNMVKMNKDLEVLAKENLVKSDILRKLTLKEKWLAENAAIAAGQKVTPTPSATAPGLQPKSKFDEKFEKVVSPPQPVVEPKPKPVIDFNLDELKPRKPNFEERPKEQLPRPESLKKPPQQKPKGSSTNVSRSNSLKSNASNGSPKVKKAPISNNSKMQIEGILGTLRKIQSQNSSDQDEDMDVDEDVERKPNKELNSKLKEIQASSFAGTMDHIKSQLTMPTVSAQAPPSMDLSKYFPNQKQEKSSTSSTNKNQVTLKDVNLAKYFPSSPAPQRRTVETVADRLKKSQTEAALAKTKLLEDQANNQAEKTKKEVEKEGESKKITKKVADSKAVPPKRQASLDTFSLREHQMDGALDLTKKKGPTKASAGVKKPAKSGSTTSVTKATATSKGKTIKIVKKIVPKGTKAKKAAEAAQESAVVEAPPEKKPPKDEAERILDEILGDGEYRSPSSEYQRLFQDEKSPSDLSDNIDRILEESGLDVELGLPKRSSKKLVKTKSLGEGDFDMKPSKERLTGVQNILKRFESMSSVTSQNSDEQAAFKLRRMESTTSNLSSLTRSRESLVSVSDSMSDLEKTMDYLRNEWRNEATNFLQKKRDKFYAKKEEQEKESKILAKPDPLDNLPVQYRDSKLAKFFGLAASKSPENRKSPIKKKKSPSKTPKVTKANNSLEELAKISNVRQTKKAQPKTLKPVEVKPLKPASPVPDDFEILDLLEKATEAKELERSKTKSPAVESISQTPKEAIVEISLPVEDIKNLPKTGCDKSSNSSRRGSQSSLIMSRRHSEISLNEKLNQDALAALNQIEKEREAEQVDELFQSMVEEMEQEPQPTAIVEPPEEDIDADSLCTTISKSPSAQPVTVVKRGSSEDQSIEKLFSHFSDEMLVNVEFDSNDELVGITPRATLVSRNTEDRDYLDKLESLERDEETFQPVVGEKFIQENVQDEVDGLHFPSRPQRRPKSSSSSSEPSLPVAPQRLKKKLSKLDPEDMPPSVQDLLQQVYQKNIQPELVEVIPVEGKQTLRFPSMLAEEDVDEVDHSKEGIKKIETAPEEVRKVTEPEDVARVIPSPIKPSISQSNSLKSENSSGSSLVEIPKIITPPKSSSKENSSDWDMEKLPASPMPRRRLLPNQTPYKAPSVASKESSLEWDMEKLPNSPMLPRRNKMRAISPSTNPVQLLNNLPSDVDDEAAQRRLIEDFEQERRQALIKRDENFEAIAAEQRRRDSLQSSSNSSSKRSLPPPTPPMMASRRGTTQDTNRTQDTASRHEGTPPMFKKLDVDGSGTSMDSTSCSTRRSSFAFIELQDNKPVIVPMPKKLKLPKPEPPRFVPEPVATDEPVPEVFQGRAWPKTQLEGEVDLGDSDNEDETEKLKKQLPEYARSDSPPSAAFKNRKWPDGKTVFDKRAESLEEEDIFEGLLSPRKRGSQRFMDKPRSQSPQPFKPLANSSRKSSKSFSDLKKGPSLQSLSAQSSQDTDTLSTTTTVATARPASYANYEDPMDASTQALLDRSKRLHNRKRDFVNERVVERNPYMRDVLRSTDRRDYDDVDEDLTSYRPRHYASSTLNRFPNTTIRKSNNYDYLSPSSDYLSRRSYIPSASATSSYYPSTTRSSHLSDLFRRRSPASGTVSALSGYGNKESCIGLALDRVGHLIESKCTWVRSTKVQTESESTSPDEVELNSATEISTDSEFDNDEIIRQAPKIFIDDTHLRKPTKVQIKSTMIGPNAASAGLHQKQLAAREKGGSYLQKYQPQPPLPQFKPLVQVDPTLLIGSQRAPLQNPRPGDYLLNKTASTEGIASKKSLELKKRYLLGEPANGNKIQKSGSTSVLDSRIRSFQSNISECQKLLNPSSDISAGMRTFLDRTKLGEGSQTTPGQTNELIRSATSNVINDLRVELRIQKTGSSHSTDNEKENVFVNCKNELNKGMEYTDAVNATLLDQLARKSSPTTPTNKTVVEVIDLVTPEKPIDIIDLTALETPKKQLVDGSAMDVDERLTPDSNKISELQQEVKEEPKPDVSRDVKECIPDILGHIKEGTGSKEPGGEDQQSLLEQSDEEKRDSPEKDVAEHELYEPDSVQIQVPNIPWEKSKPEVMSTTGSSGSICSSSDSSSIEDIQHYILESTTSPDTQTVGGKHNVPRLEVHDTSGALMQVDSLMIVNGKYIGDPEDVKFLDMPANVIVPPAPALKTNELDMEDDQEAEAEPVTATPEPVECTVIEAERRVTAPPPLPEMGPPKLKFDSKNENKIESLKNLPLIVESNVEHSQAVKPITLNLSNLARTPDTPTTPTAHDSDKTPTGEILSRGSDSETEHTGTGQVLTETELSDWTADDCISENFVDLEFALNSNKGTIKRRKDRRRSGASKLPSGNEVIHELARQAPVVQMDGILSAIDIDDIEFMDTGSEGSCAEAYSATNTALIQNRGYMEYIEAEPKKTTRKAAPPSSYPGNLPPLMTKRDEKLGVDYIEQGAYIMHDDAKTPVNEVAPAMTQSLTDSITLNELDDDSMIISQTQPTTTEESEALTVVTSPLDTSSPRVLDQFASMLAAGKGDSTPSSSEQQPKTSTVTSSSTGPNSSTTGNVSKEPQEEDLQIQFEYVRALQQRISQISTQRRKSSKGEAPNLQLNSSAPVIESAEDPAKPAEEPLVSMRPRTTSISGKVPEIPTLSSKLEEITKERTKQKDLIHDLVMDKLQSKKQLNAEKRLHRSRQRSLLTSGYASGSSLSPTPKLAAACSPQDSNCSSQAHYHASTAEEAPKPPAERPLQKSATSTYVSPYRTVQAPTRSADLYKPRPFSEHIDSNALAGYKLGKTASFNGGKLGDFAKPIAPARVNRGGGVATADIANISASTENLRSEARARARLKSNTELGLSPEEKMQLIRSRLHYDQNRSLKPKQLEEMPSGDLAARARKMSASKSVNDLAYMVGQQQQQQVEKDAVLQAKAADFTSDPNLASGGQEKAGKTKSGRRPKDPERRKSLIQSLSSFFQKGSGSAASSSKEQGGAVAAVHSEQSERPGTSSSGTPTISDAAGGGGGGGGVFSRFRISPKSKEKSKSCFDLRNFGFGDKDMLVCNAASPAGATSASQKNHSQEYLNTTNNSRYRKQTNTAKPKPESFSSSSPQLYIHKPHHLAAAHPSALDDQTPPPIPPLPLNYQRSDDESYANETREHKKQRAISKASRQAELKRLRIAQEIQREQEEIEVQLKDLEARGVLIEKALRGEAQNIENLDATKDNDEKLLKELLEIWRNITALKKRDEELTIRQQELQLEYRHAQLKEELNLRLSCNKLDKSSADVAAEGAILNEMLEIVAKRAALRPTASQLDLTAAGSASTSAEATGIKLTGQPHDHEESII
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
558PhosphorylationPGRRKRRSGDLLPQG
CCCCCCCCCCCCCCH		40.4619429919
712PhosphorylationATKPKAKSPMQDAVD
CCCCCCCCCCCCCCC		30.3922668510
1035PhosphorylationGKKDEANSDEKNAGS
CCCCCCCCCCCCCCC		54.9522817900
1042PhosphorylationSDEKNAGSSNATTNT
CCCCCCCCCCCCCCC		20.2922817900
1049PhosphorylationSSNATTNTNNTVIPK
CCCCCCCCCCCEECC		27.9622817900
1052PhosphorylationATTNTNNTVIPKSSS
CCCCCCCCEECCCCH		23.1422817900
1194PhosphorylationETSRANASADAMSDD
HHHHHCCCCCCCCCC		26.8719429919
1199PhosphorylationNASADAMSDDEANVI
CCCCCCCCCCCCCCC		43.5619429919
1212PhosphorylationVIDEHEWSGRNFLPE
CCCCCCCCCCCCCCC		25.5319429919
1292PhosphorylationADDGKDDTEGEEFKK
CCCCCCCCCCHHHHH		56.9019429919
1340PhosphorylationKENMADRSSLKSGNS
CCCCCCHHHCCCCCC		40.3427794539
1341PhosphorylationENMADRSSLKSGNSF
CCCCCHHHCCCCCCH		40.4827794539
1518PhosphorylationQQKPKGSSTNVSRSN
CCCCCCCCCCCCCHH		32.4427794539
1522PhosphorylationKGSSTNVSRSNSLKS
CCCCCCCCCHHHCCC		31.8727794539
1524PhosphorylationSSTNVSRSNSLKSNA
CCCCCCCHHHCCCCC		24.2227794539
1526PhosphorylationTNVSRSNSLKSNASN
CCCCCHHHCCCCCCC		38.1227794539
1661PhosphorylationLAKYFPSSPAPQRRT
HHHHCCCCCCCCCCH		25.8927626673
1890PhosphorylationKKLVKTKSLGEGDFD
CCCCCCCCCCCCCCC		47.0027794539
1917PhosphorylationNILKRFESMSSVTSQ
HHHHHHHHHHCCCCC		22.6627794539
1919PhosphorylationLKRFESMSSVTSQNS
HHHHHHHHCCCCCCC		30.8227794539
1920PhosphorylationKRFESMSSVTSQNSD
HHHHHHHCCCCCCCH		22.2927794539
1922PhosphorylationFESMSSVTSQNSDEQ
HHHHHCCCCCCCHHH		26.9227794539
1923PhosphorylationESMSSVTSQNSDEQA
HHHHCCCCCCCHHHH		25.8027794539
2033PhosphorylationFGLAASKSPENRKSP
HHHHCCCCCCCCCCC		34.6427794539
2059PhosphorylationKVTKANNSLEELAKI
CCCCCCCCHHHHHHH		36.6427794539
2118PhosphorylationKELERSKTKSPAVES
HHHHHHCCCCCCHHH		37.6927794539
2120PhosphorylationLERSKTKSPAVESIS
HHHHCCCCCCHHHHC		24.2727794539
2129PhosphorylationAVESISQTPKEAIVE
CHHHHCCCCHHHEEE		29.5427794539
2242PhosphorylationLCTTISKSPSAQPVT
CCCCCCCCCCCCCEE		19.8027794539
2255PhosphorylationVTVVKRGSSEDQSIE
EEEEECCCCCHHHHH		34.2927794539
2256PhosphorylationTVVKRGSSEDQSIEK
EEEECCCCCHHHHHH		48.2827794539
2260PhosphorylationRGSSEDQSIEKLFSH
CCCCCHHHHHHHHHC		45.0727794539
2309PhosphorylationDYLDKLESLERDEET
HHHHHHHHHCCCHHH		46.0627794539
2473PhosphorylationSLKSENSSGSSLVEI
CCCCCCCCCCCCEEC		55.0327794539
2746PhosphorylationGEVDLGDSDNEDETE
EECCCCCCCCHHHHH		40.3027794539
2765PhosphorylationQLPEYARSDSPPSAA
HHHHHHHCCCCCCHH		33.9827794539
2767PhosphorylationPEYARSDSPPSAAFK
HHHHHCCCCCCHHHC		39.7027794539
3174PhosphorylationYLLNKTASTEGIASK
CCCCCCCCCCCCCCC		32.0227794539
3326PhosphorylationDQLARKSSPTTPTNK
HHHHHCCCCCCCCCC		29.3327626673
3433PhosphorylationQQSLLEQSDEEKRDS
HHHHHHCCHHHHCCC		37.3019429919
4085PhosphorylationLHRSRQRSLLTSGYA
HHHHHHHHHHHCCCC		21.2821082442
4093PhosphorylationLLTSGYASGSSLSPT
HHHCCCCCCCCCCCC		30.6221082442
4095PhosphorylationTSGYASGSSLSPTPK
HCCCCCCCCCCCCHH		26.1321082442
4221PhosphorylationDIANISASTENLRSE
HHHHCCCCCHHHHHH		29.4829892262
4222PhosphorylationIANISASTENLRSEA
HHHCCCCCHHHHHHH		28.7125749252
4244PhosphorylationSNTELGLSPEEKMQL
CCCCCCCCHHHHHHH		28.5927794539
4289PhosphorylationRKMSASKSVNDLAYM
HHHHHCCCHHHHHHH		24.5322817900
4319PhosphorylationQAKAADFTSDPNLAS
HHHHCCCCCCCCCCC		32.5419429919
4320PhosphorylationAKAADFTSDPNLASG
HHHCCCCCCCCCCCC		51.5719429919
4349PhosphorylationKDPERRKSLIQSLSS
CCHHHHHHHHHHHHH		28.9719429919
4353PhosphorylationRRKSLIQSLSSFFQK
HHHHHHHHHHHHHHH		24.1922817900
4426PhosphorylationKSKEKSKSCFDLRNF
CCCCCCCCCCCCCCC		27.4012110185
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MICAL_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MICAL_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MICAL_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SOX14_DROMESox14genetic
19881505
MSRB_DROMESelRgenetic
24212093
INSR_DROMEInRgenetic
24068890
RHEB_DROMERhebgenetic
24068890
ACT1_DROMEAct5Cphysical
22116028
ACT1_DROMEAct5Cphysical
27454820
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MICAL_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1049; SER-1194;SER-1199; SER-1212; SER-4349; SER-4353 AND SER-4426, AND MASSSPECTROMETRY.

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