| UniProt ID | JIP1_DROME | |
|---|---|---|
| UniProt AC | Q9W0K0 | |
| Protein Name | JNK-interacting protein 1 | |
| Gene Name | Aplip1 | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 490 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).. | |
| Protein Sequence | MADSEFEEFHRPIFEPHTIAGFGSGAGSKKNNPHAFYSLIPNDDLEDSHSSKSDGDGSDQEDGIGLVDHEPKMRQVEDDELGDGLKVTLSSDGSLDTNDSFNSHRHHPLNHQDAIGGFLGMDTSGLGGNSAPVTIGASTDLLAPNTAATRRRRKLPEIPKNKKSSILHLLGGSNFGSLADEFRNGGGGGIPPAVRSGQQRSFLSLKCGYLMDEDSSPDSERMQSLGDVDSGHSTAHSPNDFKSMSPQITSPVSQSPFPPPFGGVPFGQLEMLEATHRGLHKFVPRHHDEIELEIGDAIYVQKEAEDLWCEGVNLRTGRQGIFPSAYAVDLDYNEFDPTVQLVKKERYLLGYLGSVETLAHKGTGVVCQAVRKIVGEYGNSPTGQTCILEVSDQGLRMVDRSGPNQNKKDKKPCIDYFYSLKNVSFCAFHPRDHRFIGFITKHPTVQRFACHVFKGSESTRPVAEAVGRAFQRFYQKFIETAYPIEDIYIE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 88 | Phosphorylation | LGDGLKVTLSSDGSL CCCCCEEEECCCCCC | 21.23 | 22817900 | |
| 97 | Phosphorylation | SSDGSLDTNDSFNSH CCCCCCCCCCCCCCC | 46.34 | 22817900 | |
| 103 | Phosphorylation | DTNDSFNSHRHHPLN CCCCCCCCCCCCCCC | 21.64 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of JIP1_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of JIP1_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of JIP1_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HEP_DROME | hep | physical | 11912189 | |
| JNK_DROME | bsk | physical | 11912189 | |
| KLC_DROME | Klc | physical | 11912189 | |
| A4_DROME | Appl | physical | 11912189 | |
| HIW_DROME | hiw | genetic | 23904612 | |
| DYHC_DROME | Dhc64C | genetic | 16332540 | |
| FUTSC_DROME | futsch | genetic | 23904612 | |
| JIP1_DROME | Aplip1 | physical | 11912189 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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