ULA1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ULA1_DROME
• UniProt AC: Q9VTE9
• Protein Name: Nedd8-activating enzyme E1 regulatory subunit
• Gene Name: APP-BP1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 524
• Protein Description: Regulatory subunit of the dimeric Uba3-APP-BP1 E1 enzyme. E1 activates Nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a Nedd8-Uba3 thioester and free AMP. E1 finally transfers Nedd8 to the catalytic cysteine of Ubc12. Required for Cul1 and Cul3 neddylation. Appl and APP-BP1 interact antagonistically during development..
• Protein Sequence: MSSPAPKSPELSDKSKKYDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGNNFFLDSSYLGKSKALACMQLLQELNPDVNGDYVDESADFLLANRPNFFDSFDLVIASNLNEQTLLLLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRLEHPFDALREHLDGTEVTSKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEMKADEENYEEAIKAVNTAFGAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLPGVLPDMTANTDSYIALQHIYRQQALQDADQVYHKCQEYLKQLALPADSIDERSVRLICKEAAGLAVIRGTRIAEEYEKSSRLLPLVEDNELQGNLTAYNFALRAYERFLSECGNIPGECIVEQDIGRLKSIAAKMLSDLGMHATISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKIITKQYKPIDNTFIYNAITTESVTLKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSPAPKSP ------CCCCCCCCH	45.06	19429919
3	Phosphorylation	-----MSSPAPKSPE -----CCCCCCCCHH	24.63	19429919
8	Phosphorylation	MSSPAPKSPELSDKS CCCCCCCCHHHCHHH	23.65	19429919
12	Phosphorylation	APKSPELSDKSKKYD CCCCHHHCHHHHHHH	41.13	29892262
233	Phosphorylation	QQADGTQTPRNYKEK HHCCCCCCCCCHHHH	24.85	25749252

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ULA1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ULA1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ULA1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBA3_DROME	Uba3	physical	21931660

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.