SLOB_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SLOB_DROME
• UniProt AC: Q8IPH9
• Protein Name: Slowpoke-binding protein
• Gene Name: Slob
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 515
• Subcellular Localization: Cytoplasm . Enriched in synaptic boutons.
• Protein Description: Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively..
• Protein Sequence: MFKFNKAAQQQRIDNRNSAVTGHDPFVRPPVPEKKVRNIMKKLHKANGLKRSNSAIEFDVSALTAANRRQIYSSNRSASSEQDNSDLSEHSEKSPLVSARLDNLARLFFSKSMPAETGSRDTIDSVLTTRPNIKYQYSALDSGNGIVERSPRERAQREKALNATQEWIQGANGRYEVIAHLDEIGSRHGKNWFLVTDASVRTDRLQTLLPLPPDCVAFEDLPPNECAREILMELLGSLHHPYIYPVLDLGFLRNSSYNYACLVTPFNSRGSLKDLIYKAQWNEPWARKYTRKPNGLPVSQVQRLGRQILEALLFLKERGFPLHGHLHSGNVILQNGAARLSGLENGLLGLSSRINAVMWSRSVTEIENVDIVCFGHLLYEMCTGQELTTPKPSMRVLEMELQHYPQIGQTRKQILEILGLIFEPPSGVCPSVEDLVLCDLFRSIDLRELRGPCFSTIKPSLSRSTLNLLQAVKKRQCASLGHSLSEANSPCTPPSTPHDRRTGVLPAPYEVFRMY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Phosphorylation	NGLKRSNSAIEFDVS CCCCCCCCCCCCCHH	31.69	10230800
79	Phosphorylation	YSSNRSASSEQDNSD HCCCCCCCCCCCCCC	35.34	10230800
112	Phosphorylation	ARLFFSKSMPAETGS HHHHHCCCCCCCCCC	28.88	27794539
119	Phosphorylation	SMPAETGSRDTIDSV CCCCCCCCCCCCHHH	34.11	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
54	S	Phosphorylation	Kinase	PKA-C1	P12370	GPS
54	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SLOB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SLOB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FEM1B_DROME	Fem-1	physical	14605208
SLO_DROME	slo	physical	9539129

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A dynamically regulated 14-3-3, Slob, and Slowpoke potassium channelcomplex in Drosophila presynaptic nerve terminals.";
Zhou Y., Schopperle W.M., Murrey H., Jaramillo A., Dagan D.,Griffith L.C., Levitan I.B.;
Neuron 22:809-818(1999).
Cited for: PHOSPHORYLATION AT SER-54 AND SER-79, INTERACTION WITH SLO AND14-3-3-ZETA, AND MUTAGENESIS OF SER-54 AND SER-79.
PubMed: 10230800