ACT6_DROME - dbPTM
ACT6_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACT6_DROME
UniProt AC P83967
Protein Name Actin, indirect flight muscle
Gene Name Act88F
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 376
Subcellular Localization Cytoplasm, cytoskeleton.
Protein Description Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Required for proper formation of indirect flight muscle (IFM) myofibrils.; Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction..
Protein Sequence MCDDDAGALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGFALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETVYNSIMKCDVDIRKDLYANSVLSGGTTMYPGIADRMQKEITALAPSTIKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKCF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Acetylation-----MCDDDAGALV
-----CCCCCCCCEE		56.37-
34PhosphorylationAPRAVFPSIVGRPRH
CCCCCCHHHCCCCCC		20.5922817900
45Methionine sulfoxideRPRHQGVMVGMGQKD
CCCCCCEEEECCCCC		2.49-
45OxidationRPRHQGVMVGMGQKD
CCCCCCEEEECCCCC		2.4922116028
48Methionine sulfoxideHQGVMVGMGQKDSYV
CCCEEEECCCCCCCC		3.32-
48OxidationHQGVMVGMGQKDSYV
CCCEEEECCCCCCCC		3.3222116028
53PhosphorylationVGMGQKDSYVGDEAQ
EECCCCCCCCCCHHH		28.8421082442
61PhosphorylationYVGDEAQSKRGILTL
CCCCHHHCCCCEEEE		31.2227794539
67PhosphorylationQSKRGILTLKYPIEH
HCCCCEEEEECEECC		21.2022668510
74MethylationTLKYPIEHGIITNWD
EEECEECCCCCCCHH		33.21-
107PhosphorylationEEHPVLLTEAPLNPK
CCCCEEEEECCCCCC		26.4122817900
241PhosphorylationSTSLEKSYELPDGQV
HCCCHHHEECCCCCE		32.3329892262
324PhosphorylationEITALAPSTIKIKII
HHHHHCCCEEEEEEE		36.8427794539
325PhosphorylationITALAPSTIKIKIIA
HHHHCCCEEEEEEEC		25.8227794539
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ACT6_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ACT6_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ACT6_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MLR_DROMEMlc2physical
22036573
GSTS1_DROMEGstS1physical
22036573
FTN_DROMEflnphysical
22036573
GPDA_DROMEGpdhphysical
22036573
TPM2_DROMETm2physical
22036573
MYSA_DROMEMhcphysical
22036573
ADH_DROMEAdhphysical
22036573
MLC1_DROMEMlc1physical
22036573
ALF_DROMEAldphysical
22036573
TNNT_DROMEupgenetic
23294764
TNNI_DROMEwupAgenetic
23294764
MYSA_DROMEMhcgenetic
11134077
MYSA_DROMEMhcgenetic
15075240
FTN_DROMEflngenetic
11134077
CISY_DROMEkdnphysical
22036573
UBIQP_DROMEUbi-p63Ephysical
12949144
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ACT6_DROME

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Related Literatures of Post-Translational Modification

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