MLR_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MLR_DROME
• UniProt AC: P18432
• Protein Name: Myosin regulatory light chain 2
• Gene Name: Mlc2
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 222
• Protein Sequence: MADEKKKVKKKKTKEEGGTSETASEAASEAATPAPAATPAPAASATGSKRASGGSRGSRKSKRAGSSVFSVFSQKQIAEFKEAFQLMDADKDGIIGKNDLRAAFDSVGKIANDKELDAMLGEASGPINFTQLLTLFANRMATSGANDEDEVVIAAFKTFDNDGLIDGDKFREMLMNFGDKFTMKEVDDAYDQMVIDDKNQIDTAALIEMLTGKGEEEEEEAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADEKKKVK ------CHHHHHHHC	33.40	3025224
13	Phosphorylation	KKVKKKKTKEEGGTS HHHCCCCCCCCCCCC	53.20	28490779
19	Phosphorylation	KTKEEGGTSETASEA CCCCCCCCCHHHHHH	33.96	28490779
20	Phosphorylation	TKEEGGTSETASEAA CCCCCCCCHHHHHHH	35.90	28490779
22	Phosphorylation	EEGGTSETASEAASE CCCCCCHHHHHHHHH	34.94	28490779
24	Phosphorylation	GGTSETASEAASEAA CCCCHHHHHHHHHHC	34.88	28490779
28	Phosphorylation	ETASEAASEAATPAP HHHHHHHHHHCCCCC	34.51	28490779
32	Phosphorylation	EAASEAATPAPAATP HHHHHHCCCCCCCCC	27.34	28490779
38	Phosphorylation	ATPAPAATPAPAASA CCCCCCCCCCCCCCC	23.30	28490779
44	Phosphorylation	ATPAPAASATGSKRA CCCCCCCCCCCCCCC	28.59	28490779
46	Phosphorylation	PAPAASATGSKRASG CCCCCCCCCCCCCCC	39.22	28490779
48	Phosphorylation	PAASATGSKRASGGS CCCCCCCCCCCCCCC	18.02	28490779
61	Phosphorylation	GSRGSRKSKRAGSSV CCCCCHHHHCCCCCC	26.68	27794539
66	Phosphorylation	RKSKRAGSSVFSVFS HHHHCCCCCCHHHHC	23.50	28490779
67	Phosphorylation	KSKRAGSSVFSVFSQ HHHCCCCCCHHHHCH	26.68	28490779
70	Phosphorylation	RAGSSVFSVFSQKQI CCCCCCHHHHCHHHH	21.79	28490779
73	Phosphorylation	SSVFSVFSQKQIAEF CCCHHHHCHHHHHHH	34.02	28490779
106	Phosphorylation	DLRAAFDSVGKIAND HHHHHHHHHHHHCCH	26.73	27794539
169	Ubiquitination	DGLIDGDKFREMLMN CCCCCHHHHHHHHHH	52.42	31113955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
66	S	Phosphorylation	Kinase	MLCK	-	GPS
66	S	Phosphorylation	Kinase	MYLKA	-	PhosphoELM
67	S	Phosphorylation	Kinase	MLCK	-	GPS
67	S	Phosphorylation	Kinase	MYLKA	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MLR_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MLR_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ULA1_DROME	APP-BP1	physical	14605208
SCN60_DROME	NaCP60E	physical	14605208
MYSA_DROME	Mhc	physical	22036573
TPM2_DROME	Tm2	physical	22036573
TNNT_DROME	up	physical	22036573
MYSP1_DROME	Prm	physical	22036573
MYSP2_DROME	Prm	physical	22036573
FTN_DROME	fln	physical	22036573
TNNI_DROME	wupA	physical	22036573
GSTS1_DROME	GstS1	physical	22036573
CUA1_DROME	Acp1	physical	22036573
TNNC1_DROME	TpnC41C	physical	22036573
AT5F1_DROME	ATPsyn-b	physical	22036573
ATP5J_DROME	ATPsyn-Cf6	physical	22036573
VDAC_DROME	porin	physical	22036573
ATPK_DROME	CG4692	physical	22036573
ICLN_DROME	icln	physical	22036573
ATPO_DROME	Oscp	physical	22036573
NPLP2_DROME	Nplp2	physical	22036573
OB56D_DROME	Obp56d	physical	22036573
CISY_DROME	kdn	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66 AND SER-67, AND MASSSPECTROMETRY.
PubMed: 18327897