TNNT_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNNT_DROME
• UniProt AC: P19351
• Protein Name: Troponin T, skeletal muscle
• Gene Name: up
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 397
• Protein Description: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity..
• Protein Sequence: MSDDEEYTSSEEEEVVEETREETKPPQTPAEGEGDPEFIKRQDQKRSDLDDQLKEYITEWRKQRSKEEDELKKLKEKQAKRKVTRAEEEQKMAQRKKEEEERRVREAEEKKQREIEEKRMRLEEAEKKRQAMLQAMKDKDKKGPNFTIAKKDAGVLGLSSAAMERNKTKEQLEEEKKISLSFRIKPLAIEGFGEAKLREKAQELWELIVKLETEKYDLEERQKRQDYDLKELKERQKQQLRHKALKKGLDPEALTGKYPPKIQVASKYERRVDTRSYDDKKKLFEGGWDEISKDSNEKIWNEKKEQYTGRQKSKLPKWFGERPGKKAGEPETPEGEEDAKADEDIVEDDEEVEEEVVEEEDEEAEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 9)	Phosphorylation	-	54.49	28490779
2 (in isoform 8)	Phosphorylation	-	54.49	27794539
2	Phosphorylation	------MSDDEEYTS ------CCCHHCCCC	54.49	27794539
2 (in isoform 6)	Phosphorylation	-	54.49	28490779
2 (in isoform 5)	Phosphorylation	-	54.49	27794539
2 (in isoform 3)	Phosphorylation	-	54.49	27794539
2 (in isoform 12)	Phosphorylation	-	54.49	27794539
2 (in isoform 2)	Phosphorylation	-	54.49	27794539
8 (in isoform 9)	Phosphorylation	-	29.11	27794539
8 (in isoform 6)	Phosphorylation	-	29.11	27794539
8 (in isoform 5)	Phosphorylation	-	29.11	27794539
8 (in isoform 3)	Phosphorylation	-	29.11	27794539
8 (in isoform 2)	Phosphorylation	-	29.11	27794539
8 (in isoform 12)	Phosphorylation	-	29.11	27794539
9 (in isoform 12)	Phosphorylation	-	34.55	27794539
9 (in isoform 2)	Phosphorylation	-	34.55	27794539
9 (in isoform 5)	Phosphorylation	-	34.55	27794539
9 (in isoform 3)	Phosphorylation	-	34.55	27794539
10	Phosphorylation	DDEEYTSSEEEEVVE CHHCCCCCHHHHHHH	41.02	27794539
22 (in isoform 2)	Phosphorylation	-	59.86	27794539
23	Phosphorylation	VEETREETKPPQTPA HHHHHHHCCCCCCCC	44.06	27794539
28 (in isoform 5)	Phosphorylation	-	30.18	27794539
28 (in isoform 3)	Phosphorylation	-	30.18	27794539
65	Phosphorylation	TEWRKQRSKEEDELK HHHHHHHCCHHHHHH	41.76	27794539
150 (in isoform 12)	Phosphorylation	-	47.54	27794539
151 (in isoform 12)	Phosphorylation	-	43.73	27794539
158 (in isoform 4)	Phosphorylation	-	2.98	27794539
158 (in isoform 5)	Phosphorylation	-	2.98	27794539
159 (in isoform 4)	Phosphorylation	-	19.01	27794539
159 (in isoform 5)	Phosphorylation	-	19.01	27794539
159	Phosphorylation	DAGVLGLSSAAMERN HHHHHCCCHHHHHHC	19.01	27794539
160	Phosphorylation	AGVLGLSSAAMERNK HHHHCCCHHHHHHCC	25.70	27794539
295	Phosphorylation	WDEISKDSNEKIWNE HHHHCCCCCHHHHHH	51.10	27794539
332	Phosphorylation	KKAGEPETPEGEEDA CCCCCCCCCCCCCCC	37.04	28490779

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNNT_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNNT_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNNT_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYSA_DROME	Mhc	physical	22036573
TNNC1_DROME	TpnC41C	physical	22036573
ATP5J_DROME	ATPsyn-Cf6	physical	22036573
AT5F1_DROME	ATPsyn-b	physical	22036573
VDAC_DROME	porin	physical	22036573
ATPK_DROME	CG4692	physical	22036573
ATPO_DROME	Oscp	physical	22036573
ICLN_DROME	icln	physical	22036573
MYSA_DROME	Mhc	genetic	12750333
MYSA_DROME	Mhc	genetic	17603127
TPM2_DROME	Tm2	genetic	11359941
CISY_DROME	kdn	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.