ACT4_DROME - dbPTM
ACT4_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACT4_DROME
UniProt AC P02574
Protein Name Actin, larval muscle
Gene Name Act79B
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 376
Subcellular Localization Cytoplasm, cytoskeleton.
Protein Description Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.; Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction..
Protein Sequence MCDEEASALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDCYVGDEAQSKRGILSLKYPIEHGIITNWDDMEKVWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRTPEALFQPSFLGMESCGIHETVYQSIMKCDVDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTIKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKCF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Acetylation-----MCDEEASALV
-----CCHHHCCEEE		56.31-
34PhosphorylationAPRAVFPSIVGRPRH
CCCCCCHHHCCCCCC		20.5922817900
45Methionine sulfoxideRPRHQGVMVGMGQKD
CCCCCCEEEECCCCC		2.49-
45OxidationRPRHQGVMVGMGQKD
CCCCCCEEEECCCCC		2.4922116028
48Methionine sulfoxideHQGVMVGMGQKDCYV
CCCEEEECCCCCEEC		3.32-
48OxidationHQGVMVGMGQKDCYV
CCCEEEECCCCCEEC		3.3222116028
61PhosphorylationYVGDEAQSKRGILSL
ECCCHHHCCCCEEEC		31.2227794539
74MethylationSLKYPIEHGIITNWD
ECCCEECCCCCCCHH		33.21-
107PhosphorylationEEHPVLLTEAPLNPK
CCCCEEEEECCCCCC		26.4122817900
241PhosphorylationSTSLEKSYELPDGQV
HCCCHHHEECCCCCE		32.3329892262
324PhosphorylationEITALAPSTIKIKII
HHHHHCCCEEEEEEE		36.8427794539
325PhosphorylationITALAPSTIKIKIIA
HHHHCCCEEEEEEEC		25.8227794539
329AcetylationAPSTIKIKIIAPPER
CCCEEEEEEECCCCC		24.0621791702
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ACT4_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ACT4_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ACT4_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MYSA_DROMEMhcphysical
22036573
MLC1_DROMEMlc1physical
22036573
MYSP1_DROMEPrmphysical
22036573
MYSP2_DROMEPrmphysical
22036573
TNNT_DROMEupphysical
22036573
MLR_DROMEMlc2physical
22036573
KARG_DROMEArgkphysical
22036573
ADH_DROMEAdhphysical
22036573
TPM2_DROMETm2physical
22036573
TNNI_DROMEwupAphysical
22036573
CUA1_DROMEAcp1physical
22036573
GPDA_DROMEGpdhphysical
22036573
ACTN_DROMEActnphysical
22036573
ALF_DROMEAldphysical
22036573
TNNC1_DROMETpnC41Cphysical
22036573
DHE3_DROMEGdhphysical
22036573
OB56D_DROMEObp56dphysical
22036573
CISY_DROMEkdnphysical
22036573
CF2_DROMECf2physical
25242320
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ACT4_DROME

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Related Literatures of Post-Translational Modification

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