dbPTM

DHE3_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DHE3_DROME
UniProt AC	P54385
Protein Name	Glutamate dehydrogenase, mitochondrial
Gene Name	Gdh
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	562
Subcellular Localization	Mitochondrion matrix.
Protein Description
Protein Sequence	MYHLKSLARQGARRQQELATLAKALPTAVMQSSRGYATEHQIPDRLKDVPTAKDPRFFDMVEYFFHRGCQIAEESLVDDMKGKLTRDEKKQKVKGILMLMQPCDHIIEIAFPLRRDAGNYEMITGYRAQHSTHKTPTKGGIRFSLDVSRDEVKALSALMTFKCACVDVPFGGAKAGLKINPKEYSEHELEKITRRFTLELAKKGFIGPGVDVPAPDMGTGEREMSWIADTYAKTIGHLDINAHACVTGKPINQGGIHGRVSATGRGVFHGLENFINEANYMSQIGTTPGWGGKTFIVQGFGNVGLHTTRYLTRAGATCIGVIEHDGTLYNPEGIDPKLLEDYKNEHGTIVGYQNAKPYEGENLMFEKCDIFIPAAVEKVITSENANRIQAKIIAEAANGPTTPAADKILIDRNILVIPDLYINAGGVTVSFFEWLKNLNHVSYGRLTFKYERESNYHLLASVQQSIERIINDESVQESLERRFGRVGGRIPVTPSESFQKRISGASEKDIVHSGLDYTMERSARAIMKTAMKYNLGLDLRTAAYVNSIEKIFTTYRDAGLAF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
449	Acetylation	SYGRLTFKYERESNY EECEEEEEEECCCCH	40.75	21791702
500	Acetylation	TPSESFQKRISGASE CCCHHHHHHHCCCCH	50.08	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DHE3_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DHE3_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DHE3_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GPDA_DROME	Gpdh	physical	22036573
TNNI_DROME	wupA	physical	22036573
TNNT_DROME	up	physical	22036573
TPM2_DROME	Tm2	physical	22036573
MLR_DROME	Mlc2	physical	22036573
MYSP1_DROME	Prm	physical	22036573
MYSP2_DROME	Prm	physical	22036573
MLC1_DROME	Mlc1	physical	22036573
AT5F1_DROME	ATPsyn-b	physical	22036573
ATPK_DROME	CG4692	physical	22036573
ATP5H_DROME	ATPsyn-d	physical	22036573
CISY_DROME	kdn	physical	22036573

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DHE3_DROME

Related Literatures of Post-Translational Modification