| UniProt ID | ACTN_DROME | |
|---|---|---|
| UniProt AC | P18091 | |
| Protein Name | Alpha-actinin, sarcomeric | |
| Gene Name | Actn | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 924 | |
| Subcellular Localization | Cytoplasm, myofibril, sarcomere, Z line . Colocalizes with Smn at the Z-line of indirect flight muscles. | |
| Protein Description | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.. | |
| Protein Sequence | MMMENGLSMEYGDGYMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNNTALPDERAVMTYVSSYYHCFSGAQKAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRRTALDEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATLGEADKEFNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRKQQNNEMLRRQFAEKANIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELEKIHQAVQESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGISQEQLNEFRSSFNHFDKNRTGRLSPEEFKSCLVSLGYSIGKDRQGDLDFQRILAVVDPNNTGYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRMPPYKGPNGVPGALDYMSFSTALYGETDL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 394 | Phosphorylation | PTEGKTVSDISNSWK CCCCCCHHHHCCCCH | 34.16 | 27794539 | |
| 397 | Phosphorylation | GKTVSDISNSWKGLE CCCHHHHCCCCHHHH | 29.78 | 27794539 | |
| 799 | Phosphorylation | KNRTGRLSPEEFKSC CCCCCCCCHHHHHHH | 28.98 | 27794539 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ACTN_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ACTN_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ACTN_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TPM2_DROME | Tm2 | physical | 22036573 | |
| MYSA_DROME | Mhc | physical | 22036573 | |
| MYSP1_DROME | Prm | physical | 22036573 | |
| MYSP2_DROME | Prm | physical | 22036573 | |
| TNNT_DROME | up | physical | 22036573 | |
| MLR_DROME | Mlc2 | physical | 22036573 | |
| GPDA_DROME | Gpdh | physical | 22036573 | |
| MLC1_DROME | Mlc1 | physical | 22036573 | |
| TNNI_DROME | wupA | physical | 22036573 | |
| TNNC1_DROME | TpnC41C | physical | 22036573 | |
| DHE3_DROME | Gdh | physical | 22036573 | |
| IDH3A_DROME | l(1)G0156 | physical | 22036573 | |
| ZASP_DROME | Zasp52 | genetic | 27783625 | |
| CISY_DROME | kdn | physical | 22036573 | |
| ZASP_DROME | Zasp52 | physical | 25242320 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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