CL190_DROME - dbPTM
CL190_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CL190_DROME
UniProt AC Q9VJE5
Protein Name Restin homolog
Gene Name CLIP-190
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1690
Subcellular Localization Cytoplasm . Cytoplasm, cytoskeleton . Golgi apparatus . Microtubule-associated. Lva-CLIP-190 complexes are found at the Golgi.
Protein Description Together CLIP-190 and jar may coordinate the interaction between the actin and microtubule cytoskeleton. May link endocytic vesicles to microtubules. May play a role in formation of furrows during cellularization..
Protein Sequence MSDDTSASGGTSAPFPSPVTADPEPGATASKLPGPIRSNIPTPATSGTGIPQPSKMKAPSSFGSTGSVSKIGRPCCNHTTPKSGPPPREATSMSRESDDNLSSINSAYTDNSSAVLTANTEQFIIGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSRLTRLTTYPLAGAQTPTSPLAKSSPDRSRTVSPTASIRSSMLRSPGIGGKNGMAVGDRVIVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKVSLSPSSKKTRLSRTGSRESLTSIGTMNSIATTATSRMRMNAQQRKSSTPVKPILATPKSQFSMQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQKNDALKAKVQTLETLPMDFTKPHAFDALTKRKPAPRLFCDICDEFDQHDTEDCPIQGSEDQDYSTPSSESNNNEKERKLPAPRKYCDSCEVFGHDTSECADDETY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
38PhosphorylationKLPGPIRSNIPTPAT
CCCCCCCCCCCCCCC		39.5721082442
45PhosphorylationSNIPTPATSGTGIPQ
CCCCCCCCCCCCCCC		28.9722817900
48PhosphorylationPTPATSGTGIPQPSK
CCCCCCCCCCCCCCC		31.5321082442
61PhosphorylationSKMKAPSSFGSTGSV
CCCCCCCCCCCCCCC		32.3529892262
64PhosphorylationKAPSSFGSTGSVSKI
CCCCCCCCCCCCHHC		27.8221082442
65PhosphorylationAPSSFGSTGSVSKIG
CCCCCCCCCCCHHCC		33.5819429919
67PhosphorylationSSFGSTGSVSKIGRP
CCCCCCCCCHHCCCC		24.2519429919
69PhosphorylationFGSTGSVSKIGRPCC
CCCCCCCHHCCCCCC		21.9119429919
70 (in isoform 3)Phosphorylation-47.2028490779
71 (in isoform 3)Phosphorylation-4.3928490779
74 (in isoform 3)Phosphorylation-23.0728490779
75 (in isoform 3)Phosphorylation-3.3228490779
82 (in isoform 3)Phosphorylation-66.9928490779
190PhosphorylationFSRLTRLTTYPLAGA
CHHHHHHCCCCCCCC		22.4619429919
191PhosphorylationSRLTRLTTYPLAGAQ
HHHHHHCCCCCCCCC		27.9419429919
192PhosphorylationRLTRLTTYPLAGAQT
HHHHHCCCCCCCCCC		7.3319429919
199PhosphorylationYPLAGAQTPTSPLAK
CCCCCCCCCCCCCCC		28.1819429919
201PhosphorylationLAGAQTPTSPLAKSS
CCCCCCCCCCCCCCC		46.4919429919
202PhosphorylationAGAQTPTSPLAKSSP
CCCCCCCCCCCCCCC		21.0819429919
207PhosphorylationPTSPLAKSSPDRSRT
CCCCCCCCCCCCCCC		41.3119429919
208PhosphorylationTSPLAKSSPDRSRTV
CCCCCCCCCCCCCCC		30.0719429919
212PhosphorylationAKSSPDRSRTVSPTA
CCCCCCCCCCCCCCH		39.4219429919
214PhosphorylationSSPDRSRTVSPTASI
CCCCCCCCCCCCHHH		26.9527626673
216PhosphorylationPDRSRTVSPTASIRS
CCCCCCCCCCHHHHH		18.8719429919
218PhosphorylationRSRTVSPTASIRSSM
CCCCCCCCHHHHHHH		26.0719429919
220PhosphorylationRTVSPTASIRSSMLR
CCCCCCHHHHHHHHC		22.4819429919
228PhosphorylationIRSSMLRSPGIGGKN
HHHHHHCCCCCCCCC		24.4225749252
309PhosphorylationPIAKVSLSPSSKKTR
EEEEEECCCCCCCCC		18.4119429919
311PhosphorylationAKVSLSPSSKKTRLS
EEEECCCCCCCCCCC		51.9519429919
312PhosphorylationKVSLSPSSKKTRLSR
EEECCCCCCCCCCCC		41.3719429919
320PhosphorylationKKTRLSRTGSRESLT
CCCCCCCCCCCHHHH		35.8119429919
322PhosphorylationTRLSRTGSRESLTSI
CCCCCCCCCHHHHCH		32.0619429919
325PhosphorylationSRTGSRESLTSIGTM
CCCCCCHHHHCHHHH		35.5219429919
327PhosphorylationTGSRESLTSIGTMNS
CCCCHHHHCHHHHHH		27.8119429919
328PhosphorylationGSRESLTSIGTMNSI
CCCHHHHCHHHHHHH		25.0619429919
331PhosphorylationESLTSIGTMNSIATT
HHHHCHHHHHHHHHH		16.1229892262
352PhosphorylationMNAQQRKSSTPVKPI
HCHHHHCCCCCCCCC		41.4519429919
353PhosphorylationNAQQRKSSTPVKPIL
CHHHHCCCCCCCCCC		39.5019429919
354PhosphorylationAQQRKSSTPVKPILA
HHHHCCCCCCCCCCC		38.9119429919
362PhosphorylationPVKPILATPKSQFSM
CCCCCCCCCHHHCCH		28.0122817900
365PhosphorylationPILATPKSQFSMQDL
CCCCCCHHHCCHHHH		37.3519429919
368PhosphorylationATPKSQFSMQDLLRE
CCCHHHCCHHHHHHH		14.1119429919
605PhosphorylationNLKATSDSLESERVN
HHHHCCCCHHHHCCC		33.5325749252
653PhosphorylationNVQKADSSALDDMLR
CHHHHCCCHHHHHHH		33.1425749252
853PhosphorylationAASGEEGSKTVAKLH
HHCCCCHHHHHHHHH		28.5622817900
1681PhosphorylationCEVFGHDTSECADDE
CCCCCCCCHHCCCCC		22.2818327897
1682PhosphorylationEVFGHDTSECADDET
CCCCCCCHHCCCCCC		36.4112537569
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CL190_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CL190_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CL190_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MYS9_DROMEjarphysical
9472041
CLASP_DROMEchbphysical
15710747
LVA_DROMElvaphysical
11076973
HAIR_DROMEhphysical
23918939
MYS9_DROMEjarphysical
25694447
K10_DROMEfs(1)K10physical
23918939
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CL190_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64; SER-67; SER-216;SER-309; SER-322; SER-325; THR-327; SER-328; THR-362; THR-1681 ANDSER-1682, AND MASS SPECTROMETRY.

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