GELS_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GELS_DROME
• UniProt AC: Q07171
• Protein Name: Gelsolin
• Gene Name: Gel
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 798
• Subcellular Localization: Isoform 2: Cytoplasm, cytoskeleton.; Isoform 1: Secreted.
• Protein Description: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed..
• Protein Sequence: MDASGAATMAVLSSLLVFLALSSSLCSAGTLNARPAFPVQSGEIQPSGQNSKQAARRVMHPSFANAGRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHFWLGLETSTDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVETNAQGETRLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQIRDQDHNGRARVQIVDDFSTDADKQHFFDVLGSGSADQVPDESTADEDSAFERTDAAAVSLYKVSDASGKLKVDIIGQKPLTQAMLDTRECFILDTGSGIFVWVGKGATQKEKTDAMAKAQEFLRTKKYPAWTQIHRIVEGSESAPFKQYFDTWRDAGMSHSRLIRSALGIGSDELLNDDEIDSVVTQLKKSGGRAFGFMPDHGQNVIETITQYVAKPGSDEIVVSTVPFDEKLPLLGFASYVLTYNYEANNGDTGSLTYVWHGVKASAAARKRAFEEGLVGSKDGLLVQTNQGHEPRHFYKIFKGKLLTSFTALPVTAQLFRIRGTVESDVHASEVAADSSSLASSDAFVLHSGKSHKIYIWNGLGASAFEKQAAVDRFSDYWDDVELEQVEEGAEPDEFWEELNGEGQYDRSLGDDGAPLLESRLFHCHLSSGGFLKVEEVAQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENGKLLDTAKLYFNLEPTARSFDTVSIIRVPQGKEPRVFKRMFPNWDDNYWQNQPSYEDMKQLVIDANNEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	Phosphorylation	VIYPKTNYGKFYTGD EEECCCCCCCEECCC	27.24	-
418	Phosphorylation	SHSRLIRSALGIGSD CHHHHHHHHHCCCCH	22.35	19429919
424	Phosphorylation	RSALGIGSDELLNDD HHHHCCCCHHHCCHH	26.45	19429919
612	Phosphorylation	SGKSHKIYIWNGLGA CCCCCEEEEECCCCH	12.51	-
662	Phosphorylation	ELNGEGQYDRSLGDD HHCCCCCCCCCCCCC	24.95	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
90	Y	Phosphorylation	Kinase	SRC	-	Uniprot
612	Y	Phosphorylation	Kinase	SRC	-	Uniprot
662	Y	Phosphorylation	Kinase	SRC	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GELS_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GELS_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of GELS_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.