dbPTM

FLOT2_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FLOT2_DROME
UniProt AC	O61492
Protein Name	Flotillin-2
Gene Name	Flo2 {ECO:0000312\|FlyBase:FBgn0264078}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	438
Subcellular Localization	Membrane. In neuronal cells, associated with GPI-anchored cell-adhesion molecules..
Protein Description	May play a role in axon growth and regeneration. May be involved in epidermal cell adhesion and epidermal structure and function..
Protein Sequence	MGNIHTTGPNEALIVSGGCCGSTKKRTIVGGWAWAWWLVTDVQRLSLNVMTLNPMCENVETSQGVPLTVTGVAQCKIMKSSSYKQTDYHNDEADELLGTASEQFLGKSVKEIKQTILQTLEGHLRAILGTLTVEEVYKDRDQFAALVREVAAPDVGRMGIEILSFTIKDVYDDVQYLASLGKAQTAVVKRDADAGVAEANRDAGIREAECEKSAMDVKYSTDTKIEDNTRMYKLQKANFDQEINTAKAESQLAYELQAAKIRQRIRNEEIQIEVVERRKQIEIESQEVQRKDRELTGTVKLPAEAEAFRLQTLAQAKQCQTIEGARAEAERIRKIGSAEAHAIELVGKAEAERMRMKAHVYKQYGDAAIMNIVLESLPKIAAEVAAPLAKTDEIVLIGGNDNITNDVTRLVAQLPPSINALTGVDLSKVLSKIPGAKA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
176	Phosphorylation	DVYDDVQYLASLGKA HHHHHHHHHHHCCCC	12.23	19429919
337	Phosphorylation	ERIRKIGSAEAHAIE HHHHHHCCHHHHHHH	26.80	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FLOT2_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FLOT2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FLOT2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FLOT1_DROME	Flo1	physical	22036573
CHMP5_DROME	CG6259	physical	22036573
RS27A_DROME	RpS27A	physical	24292889
FLOT1_DROME	Flo1	genetic	16154361
ORB2_DROME	orb2	physical	24523662

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FLOT2_DROME

Related Literatures of Post-Translational Modification