dbPTM

KDM4B_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KDM4B_DROME
UniProt AC	Q9V6L0
Protein Name	Probable lysine-specific demethylase 4B
Gene Name	Kdm4B
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	590
Subcellular Localization	Nucleus .
Protein Description	Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate (By similarity)..
Protein Sequence	MKMSEVPRIKVFRPTWEEFKDFPKYVAYMESQGAHKAGLAKVVPPPEWVPRRSGYADLDALNVTIPAPICQVVTGKQGYYQQINIQKKPLTVKQFSELASTERYATPKHFDFEDLERKYWKNITYVAPIYGADVSGSITDTDQDSWNINRLGTILDYVNKDYNIQIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHFGAPKTWYVVPPECGRKLEKVANQYFPASYKNCNAYLRHKMTLISPQILKQHDVPVSKITQEAGEIMITFPFGYHAGFNHGFNCAESTNFAMERWIEYGKRAVQCTCSNDMVKISMDTFVKRFQSDRYDLWMEGRDVGRHPEDPPNAVLSAAPLPPHLDVLLCDKKMKKQCNPTKAKSFKERNPDLDLDEIQQNPNVPDDVKAMLKESVLTLDTGDLATDEADFPNEDAMSLQSPANLKTKQELLEYIDDGTEDDDEEEDFKRRKQKRRYDADYDDDWLASKRKTNSRNNRGRSPRTKDDRSISPASSTSSTSRGARRGKASGTPRKTPARRKKDSITTSPAVSSAATAVKTPTSAVVAGTTSIATTTTPPADGGGGESSSLGSHCTTASP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
324	Phosphorylation	TFVKRFQSDRYDLWM HHHHHHHHCCCEEEE	22.73	22817900
327	Phosphorylation	KRFQSDRYDLWMEGR HHHHHCCCEEEECCC	22.00	22817900
451	Phosphorylation	LEYIDDGTEDDDEEE HHHHCCCCCCCCCHH	43.14	19429919
501	Phosphorylation	PRTKDDRSISPASST CCCCCCCCCCCCCCC	34.12	27626673
538	Phosphorylation	RKKDSITTSPAVSSA CCCCCCCCCHHHHHH	30.92	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KDM4B_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KDM4B_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KDM4B_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
H32_HUMAN	HIST2H3C	physical	19061644

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KDM4B_DROME

Related Literatures of Post-Translational Modification