FRU_DROME - dbPTM
FRU_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FRU_DROME
UniProt AC Q8IN81
Protein Name Sex determination protein fruitless
Gene Name fru
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 955
Subcellular Localization Nucleus .
Protein Description Probably acts as a transcriptional regulator. Part of the somatic sex determination hierarchy; sex determination genes transformer (tra) and transformer-2 (tra-2) switch fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. Vital for the development of males and females. Controls the development of the male specific abdominal muscle of Lawrence. Plays a role in male courtship behavior and sexual orientation. Enhances male-specific expression of takeout in brain-associated fat body..
Protein Sequence MMATSQDYFGNPYALFRGPPTTLRPRESPLGVGHPHGHGHLHSHAHAHGHGHAHSHYAALDLQTPHKRNIETDVRAPPPPLPPPPLPLPPASPRYNTDQGAMDQQFCLRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESLQVRGLTDNNNLNYRSDCDKLRDSAASSPTGRGPSNYTGGLGGAGGVADAMRESRDSLRSRCERDLRDELTQRSSSSMSERSSAAAAAAAAAAAVAAAGGNVNAAAVALGLTTPTGGERSPSVGSASAAAAAAAVAAAVAAAANRSASADGCSDRGSERGTLERTDSRDDLLQLDYSNKDNNNSNSSSTGGNNNNNNNNNNNSSSNNNNSSSNRERNNSGERERERERERERDRDRELSTTPVEQLSSSKRRRKNSSSNCDNSLSSSHQDRHYPQDSQANFKSSPVPKTGGSTSESEDAGGRHDSPLSMTTSVHLGGGGGNVGAASALSGLSQSLSIKQELMDAQQQQQHREHHVALPPDYLPSAALKLHAEDMSTLLTQHALQAADARDEHNDAKQLQLDQTDNIDGRVKCFNIKHDRHPDRELDRNHREHDDDPGVIEEVVVDHVREMEAGNEHDPEEMKEAAYHATPPKYRRAVVYAPPHPDEEAASGSGSDIYVDGGYNCEYKCKELNMRAIRCSRQQHMMSHYSPHHPHHRSLIDCPAEAAYSPPVANNQAYLASNGAVQQLDLSTYHGHANHQLHQHPPSATHPSHSQSSPHYPSASGAGAGAGSVSVSIAGSASGSATSAPASVATSAVSPQPSSSSTGSTSSAAAVAAAAAAAANRRDHNIDYSTLFVQLSGTLPTLYRCVSCNKIVSNRWHHANIHRPQSHECPVCGQKFTRRDNMKAHCKIKHADIKDRFFSHYVHM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
232PhosphorylationDCDKLRDSAASSPTG
CHHHHHHHHHCCCCC		21.2119429919
235PhosphorylationKLRDSAASSPTGRGP
HHHHHHHCCCCCCCC		36.2519429919
236PhosphorylationLRDSAASSPTGRGPS
HHHHHHCCCCCCCCC		23.0419429919
238PhosphorylationDSAASSPTGRGPSNY
HHHHCCCCCCCCCCC		41.2719429919
328PhosphorylationTPTGGERSPSVGSAS
CCCCCCCCCCCCHHH		19.7519429919
330PhosphorylationTGGERSPSVGSASAA
CCCCCCCCCCHHHHH		40.1219429919
333PhosphorylationERSPSVGSASAAAAA
CCCCCCCHHHHHHHH		19.5219429919
335PhosphorylationSPSVGSASAAAAAAA
CCCCCHHHHHHHHHH		21.8219429919
373PhosphorylationERGTLERTDSRDDLL
CCCCCCCCCCCHHHC		29.0219429919
375PhosphorylationGTLERTDSRDDLLQL
CCCCCCCCCHHHCCC		36.6822668510
447PhosphorylationRDRDRELSTTPVEQL
HHHHHHHCCCHHHHH		26.0219429919
448PhosphorylationDRDRELSTTPVEQLS
HHHHHHCCCHHHHHH		47.9819429919
449PhosphorylationRDRELSTTPVEQLSS
HHHHHCCCHHHHHHC		23.2019429919
464PhosphorylationSKRRRKNSSSNCDNS
CCHHHCCCCCCCCCC		37.8719429919
465PhosphorylationKRRRKNSSSNCDNSL
CHHHCCCCCCCCCCC		34.6619429919
466PhosphorylationRRRKNSSSNCDNSLS
HHHCCCCCCCCCCCC		41.1019429919
471PhosphorylationSSSNCDNSLSSSHQD
CCCCCCCCCCCCCCC		19.1722817900
501PhosphorylationVPKTGGSTSESEDAG
CCCCCCCCCCCCCCC		39.5325749252
502PhosphorylationPKTGGSTSESEDAGG
CCCCCCCCCCCCCCC		40.6029892262
517 (in isoform 3)Phosphorylation-6.6219429919
518 (in isoform 3)Phosphorylation-16.7319429919
520 (in isoform 3)Phosphorylation-9.8119429919
530 (in isoform 7)Phosphorylation-6.6219429919
531 (in isoform 7)Phosphorylation-21.3019429919
533 (in isoform 7)Phosphorylation-6.8719429919
618 (in isoform 2)Phosphorylation-8.5019429919
619 (in isoform 2)Phosphorylation-31.5719429919
621 (in isoform 2)Phosphorylation-9.8019429919
631 (in isoform 6)Phosphorylation-51.3219429919
632 (in isoform 6)Phosphorylation-63.5019429919
634 (in isoform 6)Phosphorylation-44.5819429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FRU_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FRU_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FRU_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SEM2A_DROMESema-2aphysical
14605208
AST5_DROMEacgenetic
21471381
OAF_DROMEoafgenetic
21471381
BIB_DROMEbibgenetic
21471381
AMOS_DROMEamosgenetic
21471381
NEDD8_DROMENedd8genetic
21471381
APTE_DROMEapgenetic
21471381
ECR_DROMEEcRgenetic
21471381
EVE_DROMEevegenetic
21471381
FMR1_DROMEFmr1genetic
21471381
KRUP_DROMEKrgenetic
21471381
HUNB_DROMEhbgenetic
21471381
NEUR_DROMEneurgenetic
21471381
TAKT_DROMEtogenetic
12435630
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FRU_DROME

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Related Literatures of Post-Translational Modification

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