NEDD8_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEDD8_DROME
• UniProt AC: Q9VJ33
• Protein Name: NEDD8
• Gene Name: Nedd8
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 84
• Subcellular Localization: Nucleus. Mainly nuclear..
• Protein Description: Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex Uba3-Ula1 and linkage to the E2 enzyme Ubc12. Attachment of Nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins..
• Protein Sequence: MLIKVKTLTGKEIEIDIEPTDKVDRIKERVEEKEGIPPQQQRLIFSGKQMNDDKTAADYKVQGGSVLHLVLALRGGDSILTPCV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Acetylation	QRLIFSGKQMNDDKT HEEEEECCCCCCCCC	45.21	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NEDD8_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NEDD8_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEDD8_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTRO_DROME	Patronin	physical	14605208
DRICE_DROME	Ice	physical	21145488

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.