| UniProt ID | PTRO_DROME | |
|---|---|---|
| UniProt AC | A1ZAU8 | |
| Protein Name | Patronin | |
| Gene Name | Patronin | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 1630 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes to centrosomes in prophase, to the midbody during cytokinesis, diffusely throughout the metaphase | |
| Protein Description | Involved in mitotic spindle assembly. [PubMed: 17412918 Regulates microtubule (MT) severing] | |
| Protein Sequence | MDVETQEIRQARQRASVKWLLSKAFNNRVPDNLKEPFYRDHENQERLKPQIIVELGNATLYCQTLANLYSDPNYQSMNHWSIIQTLARKGVPVAESADMPITETVLIQTNPLRINAHMSVIESLMVLYAKEISSGDRVMAAIRRISGNNYQAPTGQSYEQALLGWISHACAALKKRIIKEVDAGLPDDNGSRLQTPDIPPVRDFQDLCDGICLALLISYYCPKVVPWTSVRINYLPAVEDSIHNILLVCNFSQKHLPYTVMHMTPEDVTYMRGSMKLNLVVLLTDLFNLFEIHPAKCVCYPGMDGQVPHSNSFGGGLNRRSTPPNEYQTVQSNNFDGNHAEAFVVHKSRGITTLASMHSQQQQQLHQQQQHQQQYHQQPLQQHPSQSQLQIQQQEPLVPARLRQAKEKTNVESKADERGRRSRRNSSSEDSQLTIENFGGSQDQLNTLGRYERDRERKLSNTSVGSYPVEPAVAVRSSIADARGTLQLGYDTDSGSEKQDRETEKYSMRRQVSVDNVPTVSSHNLSNAGSPLPVARHKQHSSDKDYSSNSGMTPDAYNDSRSTSGYDPESTPVRKSSTSSMPASPAAWQLDVGDDDMRSLENASKLSTIRMKLEEKRRRIEQDKRKIEMALLRHQEKEDLESCPDVMKWETMSNESKRTPDMDPVDLDKYQQSIAIMNMNLQDIQQDIHRLATQQSQMQAQHLQAQQLMQAQQIANMLNQAYNAPVSAYSSRPPSRDPYQQQLHHQQQQPMPMPQPMQYVNEHGQYMSPPQPAHYMPQQAQQPQSIYSDNGAAYNHSNHSPYGGTPQYRSSVVYDDYGQPTNHFYLHESSPQPQAHQHPQRRTWAHSAAAAAYEQQQQIQPSLVDVNAWQTQQHQKQKQTWMNRPPSSAGAPSPGSFMLHQNGGGGGGGGGGGELQHLFQVQASPQHGQRQVSGSNGVQRQQSLTNLRDNRSPKAPQNMGMPMGMPMQQEDMMAPQSICFIGDEEDVDELERNIIESMQSTHISDFVHQQQQQHQHQQQLQQQQRLQGHSGRGSSSEDYDSGEMISNKLNITSGNLTYRIPSPSRPSIQANSFQDPRAMAAASGGEDQPPEKGFYISFDDEQPKRPKPPLRAKRSPKKESPPGSRDSVDNQATLKRESLSHLHNNNNIGFGNDDVNSKPVTRHSIHGLNNSNSVKSPGNATYNKYTDEPPIQLRQLAVSGAMSPTSNERHHLDDVSNQSPQQTQQPMSPTRLQQSSNNAEAAKNKALVIGADSTNLDPESVDEMERRKEKIMLLSLQRRQQQEEAKARKEIEASQKREKEREKEEERARKKEEQMARRAAILEQHRLKKAIEEAEREGKTLDRPDLHVKLQSHSSTSTTPRLRQQRTTRPRPKTIHVDDASVDISEASSISSRGKKGSSSNLTGYGQLSSNSMKRDYYRGSQDSLTVKESPDDYPSTSSTPIGRRGSYKTSREPAGVERGRTLSRISVAKGSTLNFRGRKSNSLMNLCGPKLYKQPAAKSNRGIILNAVEYCVFPGVVNREAKQKVLEKIARSEAKHFLVLFRDAGCQFRALYSYQPETDQVTKLYGTGPSQVEEVMFDKFFKYNSGGKCFSQVHTKHLTVTIDAFTIHNSLWQGKRVQLPSKKDMALVI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 310 | Phosphorylation | MDGQVPHSNSFGGGL CCCCCCCCCCCCCCC | 21082442 | ||
| 312 | Phosphorylation | GQVPHSNSFGGGLNR CCCCCCCCCCCCCCC | 21082442 | ||
| 321 | Phosphorylation | GGGLNRRSTPPNEYQ CCCCCCCCCCCCCCC | 19429919 | ||
| 322 | Phosphorylation | GGLNRRSTPPNEYQT CCCCCCCCCCCCCCC | 19429919 | ||
| 327 | Phosphorylation | RSTPPNEYQTVQSNN CCCCCCCCCCEECCC | 23607784 | ||
| 422 | Phosphorylation | ADERGRRSRRNSSSE HHHHHHHHCCCCCCC | 18327897 | ||
| 426 | Phosphorylation | GRRSRRNSSSEDSQL HHHHCCCCCCCCCCC | 19429919 | ||
| 427 | Phosphorylation | RRSRRNSSSEDSQLT HHHCCCCCCCCCCCE | 19429919 | ||
| 428 | Phosphorylation | RSRRNSSSEDSQLTI HHCCCCCCCCCCCEE | 19429919 | ||
| 428 (in isoform 2) | Phosphorylation | - | 21082442 | ||
| 428 (in isoform 3) | Phosphorylation | - | 21082442 | ||
| 431 | Phosphorylation | RNSSSEDSQLTIENF CCCCCCCCCCEEECC | 19429919 | ||
| 434 | Phosphorylation | SSEDSQLTIENFGGS CCCCCCCEEECCCCC | 22668510 | ||
| 437 (in isoform 3) | Phosphorylation | - | 27626673 | ||
| 437 (in isoform 2) | Phosphorylation | - | 27626673 | ||
| 441 | Phosphorylation | TIENFGGSQDQLNTL EEECCCCCHHHHHHH | 19429919 | ||
| 447 | Phosphorylation | GSQDQLNTLGRYERD CCHHHHHHHCCHHHH | 19429919 | ||
| 460 | Phosphorylation | RDRERKLSNTSVGSY HHHCCCCCCCCCCCC | 21082442 | ||
| 462 | Phosphorylation | RERKLSNTSVGSYPV HCCCCCCCCCCCCCC | 19429919 | ||
| 463 | Phosphorylation | ERKLSNTSVGSYPVE CCCCCCCCCCCCCCC | 19429919 | ||
| 466 | Phosphorylation | LSNTSVGSYPVEPAV CCCCCCCCCCCCCEE | 19429919 | ||
| 467 | Phosphorylation | SNTSVGSYPVEPAVA CCCCCCCCCCCCEEE | 19429919 | ||
| 477 | Phosphorylation | EPAVAVRSSIADARG CCEEEHHCHHHCCCC | 19429919 | ||
| 478 | Phosphorylation | PAVAVRSSIADARGT CEEEHHCHHHCCCCE | 19429919 | ||
| 490 | Phosphorylation | RGTLQLGYDTDSGSE CCEEEECCCCCCCCC | 19429919 | ||
| 492 | Phosphorylation | TLQLGYDTDSGSEKQ EEEECCCCCCCCCCC | 19429919 | ||
| 494 | Phosphorylation | QLGYDTDSGSEKQDR EECCCCCCCCCCCCH | 19429919 | ||
| 496 | Phosphorylation | GYDTDSGSEKQDRET CCCCCCCCCCCCHHH | 19429919 | ||
| 513 | Phosphorylation | YSMRRQVSVDNVPTV HHHCCCCCCCCCCCC | 19429919 | ||
| 519 | Phosphorylation | VSVDNVPTVSSHNLS CCCCCCCCCCCCCCC | 19429919 | ||
| 521 | Phosphorylation | VDNVPTVSSHNLSNA CCCCCCCCCCCCCCC | 19429919 | ||
| 522 | Phosphorylation | DNVPTVSSHNLSNAG CCCCCCCCCCCCCCC | 19429919 | ||
| 526 | Phosphorylation | TVSSHNLSNAGSPLP CCCCCCCCCCCCCCC | 19429919 | ||
| 530 | Phosphorylation | HNLSNAGSPLPVARH CCCCCCCCCCCCCCC | 19429919 | ||
| 566 | Phosphorylation | DSRSTSGYDPESTPV CCCCCCCCCCCCCCC | 18281928 | ||
| 576 | Phosphorylation | ESTPVRKSSTSSMPA CCCCCCCCCCCCCCC | 22668510 | ||
| 577 | Phosphorylation | STPVRKSSTSSMPAS CCCCCCCCCCCCCCC | 22668510 | ||
| 578 | Phosphorylation | TPVRKSSTSSMPASP CCCCCCCCCCCCCCC | 21082442 | ||
| 580 | Phosphorylation | VRKSSTSSMPASPAA CCCCCCCCCCCCCCE | 22668510 | ||
| 659 | Phosphorylation | MSNESKRTPDMDPVD CCCCCCCCCCCCCCC | 19429919 | ||
| 810 | Phosphorylation | GGTPQYRSSVVYDDY CCCCCCCCEEEECCC | 21082442 | ||
| 829 | Phosphorylation | NHFYLHESSPQPQAH CEEEEECCCCCCCCC | 21082442 | ||
| 843 | Phosphorylation | HQHPQRRTWAHSAAA CCCCCHHHHHHHHHH | 21082442 | ||
| 847 | Phosphorylation | QRRTWAHSAAAAAYE CHHHHHHHHHHHHHH | 21082442 | ||
| 933 | Phosphorylation | QHGQRQVSGSNGVQR CCCCCCCCCCCCHHH | 21082442 | ||
| 943 | Phosphorylation | NGVQRQQSLTNLRDN CCHHHHHHHHHCCCC | 25749252 | ||
| 945 | Phosphorylation | VQRQQSLTNLRDNRS HHHHHHHHHCCCCCC | 27626673 | ||
| 1030 | Phosphorylation | QQRLQGHSGRGSSSE HHHHCCCCCCCCCCC | 22668510 | ||
| 1034 | Phosphorylation | QGHSGRGSSSEDYDS CCCCCCCCCCCCCCC | 19429919 | ||
| 1035 | Phosphorylation | GHSGRGSSSEDYDSG CCCCCCCCCCCCCCC | 19429919 | ||
| 1036 | Phosphorylation | HSGRGSSSEDYDSGE CCCCCCCCCCCCCCC | 19429919 | ||
| 1039 | Phosphorylation | RGSSSEDYDSGEMIS CCCCCCCCCCCCEEC | 19429919 | ||
| 1052 | Phosphorylation | ISNKLNITSGNLTYR ECCCEEECCCCEEEE | 21082442 | ||
| 1057 | Phosphorylation | NITSGNLTYRIPSPS EECCCCEEEECCCCC | 21082442 | ||
| 1062 | Phosphorylation | NLTYRIPSPSRPSIQ CEEEECCCCCCCCCC | 19429919 | ||
| 1064 | Phosphorylation | TYRIPSPSRPSIQAN EEECCCCCCCCCCCC | 19429919 | ||
| 1067 | Phosphorylation | IPSPSRPSIQANSFQ CCCCCCCCCCCCCCC | 19429919 | ||
| 1120 | Phosphorylation | KRSPKKESPPGSRDS CCCCCCCCCCCCCCC | 22668510 | ||
| 1124 | Phosphorylation | KKESPPGSRDSVDNQ CCCCCCCCCCCCCCH | 19429919 | ||
| 1127 | Phosphorylation | SPPGSRDSVDNQATL CCCCCCCCCCCHHHH | 19429919 | ||
| 1138 | Phosphorylation | QATLKRESLSHLHNN HHHHCHHHHHHHHCC | 19429919 | ||
| 1140 | Phosphorylation | TLKRESLSHLHNNNN HHCHHHHHHHHCCCC | 19429919 | ||
| 1161 | Phosphorylation | DVNSKPVTRHSIHGL CCCCCCCCHHHCCCC | 19429919 | ||
| 1164 | Phosphorylation | SKPVTRHSIHGLNNS CCCCCHHHCCCCCCC | 19429919 | ||
| 1176 | Phosphorylation | NNSNSVKSPGNATYN CCCCCCCCCCCCCCC | 19429919 | ||
| 1181 | Phosphorylation | VKSPGNATYNKYTDE CCCCCCCCCCCCCCC | 21082442 | ||
| 1203 | Phosphorylation | LAVSGAMSPTSNERH HHHCCCCCCCCCCCC | 19429919 | ||
| 1205 | Phosphorylation | VSGAMSPTSNERHHL HCCCCCCCCCCCCCC | 19429919 | ||
| 1206 | Phosphorylation | SGAMSPTSNERHHLD CCCCCCCCCCCCCCC | 19429919 | ||
| 1219 | Phosphorylation | LDDVSNQSPQQTQQP CCCCCCCCCHHHCCC | 29892262 | ||
| 1223 | Phosphorylation | SNQSPQQTQQPMSPT CCCCCHHHCCCCCHH | 29892262 | ||
| 1228 | Phosphorylation | QQTQQPMSPTRLQQS HHHCCCCCHHHHHHC | 19429919 | ||
| 1230 | Phosphorylation | TQQPMSPTRLQQSSN HCCCCCHHHHHHCCC | 19429919 | ||
| 1275 | Phosphorylation | KEKIMLLSLQRRQQQ HHHHHHHHHHHHHHH | 19429919 | ||
| 1352 | Phosphorylation | DLHVKLQSHSSTSTT CCEEEEECCCCCCCC | 21082442 | ||
| 1354 | Phosphorylation | HVKLQSHSSTSTTPR EEEEECCCCCCCCHH | 21082442 | ||
| 1355 | Phosphorylation | VKLQSHSSTSTTPRL EEEECCCCCCCCHHH | 21082442 | ||
| 1356 | Phosphorylation | KLQSHSSTSTTPRLR EEECCCCCCCCHHHH | 21082442 | ||
| 1357 | Phosphorylation | LQSHSSTSTTPRLRQ EECCCCCCCCHHHHC | 21082442 | ||
| 1358 | Phosphorylation | QSHSSTSTTPRLRQQ ECCCCCCCCHHHHCC | 18511481 | ||
| 1359 | Phosphorylation | SHSSTSTTPRLRQQR CCCCCCCCHHHHCCC | 21082442 | ||
| 1370 (in isoform 3) | Phosphorylation | - | 19429919 | ||
| 1371 (in isoform 3) | Phosphorylation | - | 19429919 | ||
| 1372 (in isoform 3) | Phosphorylation | - | 19429919 | ||
| 1383 (in isoform 3) | Phosphorylation | - | 27626673 | ||
| 1390 (in isoform 3) | Phosphorylation | - | 19429919 | ||
| 1398 | Phosphorylation | SSRGKKGSSSNLTGY CCCCCCCCCCCCCCC | 23607784 | ||
| 1399 | Phosphorylation | SRGKKGSSSNLTGYG CCCCCCCCCCCCCCC | 23607784 | ||
| 1400 | Phosphorylation | RGKKGSSSNLTGYGQ CCCCCCCCCCCCCCC | 19060867 | ||
| 1403 | Phosphorylation | KGSSSNLTGYGQLSS CCCCCCCCCCCCCCC | 21082442 | ||
| 1412 | Phosphorylation | YGQLSSNSMKRDYYR CCCCCCCCCCCCCCC | 21082442 | ||
| 1418 | Phosphorylation | NSMKRDYYRGSQDSL CCCCCCCCCCCCCCE | 25749252 | ||
| 1421 | Phosphorylation | KRDYYRGSQDSLTVK CCCCCCCCCCCEEEC | 25749252 | ||
| 1424 | Phosphorylation | YYRGSQDSLTVKESP CCCCCCCCEEECCCC | 25749252 | ||
| 1493 | Phosphorylation | NLCGPKLYKQPAAKS HHHCCHHHCCCCCCC | 18281928 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PTRO_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PTRO_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PTRO_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RS16_DROME | RpS16 | physical | 14605208 | |
| TPM2_DROME | Tm2 | physical | 14605208 | |
| H2AV_DROME | His2Av | physical | 14605208 | |
| ATP5H_DROME | ATPsyn-d | physical | 14605208 | |
| NHK1_DROME | ball | physical | 14605208 | |
| CPSF6_DROME | CG7185 | physical | 14605208 | |
| FEM1B_DROME | Fem-1 | physical | 14605208 | |
| SPTCA_DROME | alpha-Spec | physical | 27231092 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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