C2D1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: C2D1_DROME
• UniProt AC: Q9VKJ9
• Protein Name: Coiled-coil and C2 domain-containing protein 1-like
• Gene Name: l(2)gd1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 816
• Subcellular Localization: Cytoplasm .
• Protein Description: Negative regulator of the Notch signaling pathway, acting to restrict the activity of Notch to the dorsoventral (D/V) boundary of the wing imaginal disk. Also causes negative regulation of Notch during vein, eye, and bristle development. Acts by targeting Notch for endosomal degradation or recycling..
• Protein Sequence: MFSRKKPEPAKRRQHDLSQFGLTEIPDDFDPSAGYGEDDGGDSDLEAELAAITGGEGAKPKPKPKAKLLPASDLDKMIADSLRDVSDDDDDDNLESDPDLLGELSGIGGLEEAEEEEPVAQPPAASEEPVQTFLPTTTVDTLSIIKQRLEMYKQAEANAKTAGDSGKARRFGRGLKTLKDLHRQAAAGKSINVDDIPPEVSVKPIGGQAPPVPAEESPAPSTPASPPPVPSRAAPDPPTPGTPVEPTTSVAPTSPPNPLVTQMRSRQTDYKAAALQSKRSGDISTALQFLKVVKQFDVVIKMCEDGQEVDLSDMPPPPAEFLEFLKKMQEEAAAEAVAEPTAAPEPTPVAPAPVLAAATNMLEALQQRLEKYQSVEAAAKAENNSGKARRFGRIVKQYEDAIKLYKAGKPVPYDELPVPPGFGPLPTADAAPVAPTPSLPTSPTSPPPTASTSAGGTPSSSSATTPTAPRKAPSPPKPKELTTRTSGNQQKNNIAEQQMKLLLERQKEFKLAAIEAKKAGEIDQAKEYLKIFKGFDSLLNAASSGLPVDLSTLPVPPSQRDNLEASFAIVSAEECDPTDDICEIGVRMEEQLAKQLMMCKNTRDHHKAMGDVAGMNRFENLALTVQKDLDLVRYSKRKNEPLPKFHYEKRSFNIVHCNTDLTDSELEIVVVRGISYNVANPKDVDTYVRVEFPLLNDESFKTKTNVIRDTSSPDYDERFKVDIQRTNRQFQRIFKRHGVKFEIYSRGGFLRSDTLIGTVNVKLQPLETKCEIHDTYDLMDGRKQVGGKLEVKIRVRNPILTKQMEHITEKWLVLDA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	GEDDGGDSDLEAELA CCCCCCCCCHHHHHH	47.58	19429919
86	Phosphorylation	ADSLRDVSDDDDDDN HHHHHCCCCCCCCCC	39.34	22817900
217	Phosphorylation	PPVPAEESPAPSTPA CCCCCCCCCCCCCCC	20.19	19429919
221	Phosphorylation	AEESPAPSTPASPPP CCCCCCCCCCCCCCC	49.48	19429919
222	Phosphorylation	EESPAPSTPASPPPV CCCCCCCCCCCCCCC	23.09	19429919
225	Phosphorylation	PAPSTPASPPPVPSR CCCCCCCCCCCCCCC	38.86	19429919
231	Phosphorylation	ASPPPVPSRAAPDPP CCCCCCCCCCCCCCC	34.48	19429919
239	Phosphorylation	RAAPDPPTPGTPVEP CCCCCCCCCCCCCCC	39.47	19429919
242	Phosphorylation	PDPPTPGTPVEPTTS CCCCCCCCCCCCCCC	25.93	19429919
247	Phosphorylation	PGTPVEPTTSVAPTS CCCCCCCCCCCCCCC	20.42	19429919
248	Phosphorylation	GTPVEPTTSVAPTSP CCCCCCCCCCCCCCC	31.74	19429919
249	Phosphorylation	TPVEPTTSVAPTSPP CCCCCCCCCCCCCCC	20.82	19429919
465	Phosphorylation	PSSSSATTPTAPRKA CCCCCCCCCCCCCCC	20.54	21082442
474	Phosphorylation	TAPRKAPSPPKPKEL CCCCCCCCCCCCCHH	59.71	19429919
486	Phosphorylation	KELTTRTSGNQQKNN CHHCCCCCCCHHHCC	32.24	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of C2D1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of C2D1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of C2D1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOTCH_DROME	N	genetic	23178945
VP33A_DROME	car	genetic	23178945
HRS_DROME	Hrs	genetic	17084357
HRS_DROME	Hrs	genetic	23178945
APH1_DROME	aph-1	genetic	23178945
FAT_DROME	ft	genetic	9335602
VG_DROME	vg	genetic	7781886
PSN_DROME	Psn	genetic	12648493
PSN_DROME	Psn	genetic	17084358
VATA1_DROME	Vha68-1	genetic	23178945

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.