VP33A_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VP33A_DROME
• UniProt AC: Q9Y1I2
• Protein Name: Vacuolar protein sorting-associated protein 33A
• Gene Name: car
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 617
• Subcellular Localization: Early endosome . Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.
• Protein Description: Required for the biogenesis of eye pigment granules. [PubMed: 10549280 Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex]
• Protein Sequence: MFPHLKGHGQRVNLQLLQEAACRELLQQLDRIEGSKVIVLDETMIGPLDLVTRPKLFADRGIRLLALKPELHLPREVANVVYVMRPRVALMEQLAAHVKAGGRAAAGRQYHILFAPRRSCLCVSQLEVSGVLGSFGNIEELAWNYLPLDVDLVSMEMPNAFRDVSVDGDTSSLYQAAVGLVQLQRLYGRIPKIYGKGEFAHRVWEHAKQLGRDERTLYNGDKGVVDQLILLDRSIDLLSPLATQLTYEGLIDEFYGIRQNKLTLPAENFPSDGALPGGGGSGPRVEESQSLLGDTEKKTILLHSGEQLYAELRNKHFNEVTKLLARKAREIHVQMHATSQDKSVQEIKSFVENLLPQLMAQKKATSEHTAIAGLLHEQVNAVRFADDLAAEQEFMVCADIDKPSAYIEDLIACRVELNRVLRLICMQCHAASGFKEKLLNHYKRELVHVYGLEVLLTISNLEKSGLLHLQTESRAYSVLRKTLHLTVDDNVEIEPKDISYVHSFYAPLTARIVEHSLKPLGWQTLKSQINNLPGPTFEDFQAQLVGIGGRHTVTTVSEGSLLNVPRVVLVCFVGGCTFAEIAALRFLAAQEDNNVEFLIATTKVVNKHSFLDSLMSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
552	Phosphorylation	VGIGGRHTVTTVSEG EEECCCCEEEEECCC	20.42	21082442
560	Phosphorylation	VTTVSEGSLLNVPRV EEEECCCCCCCCCCE	26.15	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VP33A_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VP33A_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VP33A_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VPS18_DROME	dor	physical	10549280
WHITE_DROME	w	genetic	11962627
CYTL_DROME	Cys	genetic	22426392

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.